2017
DOI: 10.4155/fsoa-2017-0083
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Liver Fibrosis: A Compilation on the Biomarkers Status and Their Significance During Disease Progression

Abstract: Liver fibrosis occurs in response to different etiologies of chronic liver injury. Diagnosing degree of liver fibrosis is a crucial step in evaluation of severity of the disease. An invasive liver biopsy is the gold standard method associated with pain and complications. Biomarkers to detect liver fibrosis include direct markers of extracellular matrix turnover and indirect markers as a reflection of liver dysfunction. Although a single marker may not be useful for successful management, a mathematical equatio… Show more

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Cited by 128 publications
(124 citation statements)
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“…As reported previously, those patients with NFS higher than 0.676, FIB-4 higher than 1.30, APRI higher than 0.50 and the BRAD score of 2-4 were diagnosed as having an advanced fibrotic liver (29)(30)(31)(32)(33), patients in NAFLD group were grouped according to high-level (>0.676) or low-level (≤0.676) NFS, high-level (>1.30) or low-level (≤1.30) FIB-4, high-level (>0.50), or low-level (≤0.50) APRI and high-score (2-4 score) or low-score (0-1 score) BRAD. NFS, FIB-4, APRI, and BARD score were compared between the NAFLD patients with or without synCRLM.…”
Section: Calculation Of Non-invasive Liver Fibrosis Scoring Modelsmentioning
confidence: 59%
“…As reported previously, those patients with NFS higher than 0.676, FIB-4 higher than 1.30, APRI higher than 0.50 and the BRAD score of 2-4 were diagnosed as having an advanced fibrotic liver (29)(30)(31)(32)(33), patients in NAFLD group were grouped according to high-level (>0.676) or low-level (≤0.676) NFS, high-level (>1.30) or low-level (≤1.30) FIB-4, high-level (>0.50), or low-level (≤0.50) APRI and high-score (2-4 score) or low-score (0-1 score) BRAD. NFS, FIB-4, APRI, and BARD score were compared between the NAFLD patients with or without synCRLM.…”
Section: Calculation Of Non-invasive Liver Fibrosis Scoring Modelsmentioning
confidence: 59%
“…Elevated levels of HA in cirrhotic liver subjects is due to imbalance between synthesis from fibrogenesis and decrease in fibrolysis during the disease progression, dysfunction of sinusoidal endothelial cells leads to reduction in degradation of HA resulting in elevated levels in circulation [8,22]. Damaged hepatocytes release Reactive Oxygen Species (ROS) and fibrogenic mediators which in turn stimulate inflammatory cells leads to cell damage [3]. Decreased hepatic ATP and cell damage result in increased uric acid production which lead to histological liver injury [23].…”
Section: Discussionmentioning
confidence: 99%
“…Existing biomarkers for cirrhosis in clinical practice have narrow applicability; unable to predict etiology (specificity) and distinguish intermediate stages (sensitivity). Ideal biomarker should be organ specific, sensitive to indicate active damage, easily accessible in peripheral tissue, cost effective; should give insights for tailor made therapy for effective clinical management of the disease [3]. Hence, the present study aimed to correlate serum levels of uric acid, HA and YKL-40 with conventional markers of liver cirrhosis.…”
mentioning
confidence: 99%
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