Liver mitochondrial oxygen consumption and proton leak kinetics in broilers supplemented with dietary copper or zinc following coccidiosis challenge

Acetoze, Gabriela; Kurzbard, R.; Klasing, Kirk C.; Ramsey, Jon J.; Rossow, Heidi A

doi:10.1111/jpn.12591

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Therefore, the increment in liver Cu concentration observed during coccidiosis may be an important mechanism of defense associated with lower levels of cellular induced apoptosis. This was already hypothesized by Acetoze et al (53) when studying the impact of supplementation of Cu and Zn above the requirements of broilers under coccidiosis challenge.…”

Section: Coppermentioning

confidence: 61%

“…Curiously, blood and liver Cu concentration are positively associated with the plasma ceruloplasmin concentration (53), a multicopper enzyme of the family of acute phase proteins that protects cells against the injuries induced by oxidative stress (53). Therefore, the increment in liver Cu concentration observed during coccidiosis may be an important mechanism of defense associated with lower levels of cellular induced apoptosis.…”

Section: Coppermentioning

confidence: 99%

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Influence of Dietary Zinc, Copper, and Manganese on the Intestinal Health of Broilers Under Eimeria Challenge

Bortoluzzi¹,

Vieira

Applegate

2020

Front. Vet. Sci.

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The incidence of enteric infections in broiler chickens may increase worldwide due to mounting pressure to limit the use of sub-therapeutic antibiotics and ionophores for coccidia suppression/prevention in the diets of broilers. For this reason, we need expand our knowledge on the role that micro-minerals have in modulating the intestinal physiology, immunology, and microbiology of broiler chickens. There are issues associated with the use of high doses of some micro-minerals in the diets of animals, such as environmental contamination, bacterial resistance, and gizzard erosion. Therefore, there is a need to maximize the absorption of these minerals by the gastrointestinal tract (GIT) of birds when intestinal function may be compromised. Zinc is an essential micromineral required for growth, and influences intestinal development and/or regeneration during and after enteric disease. Two studies were conducted by our lab to determine the effects of Zn source in broilers under coccidia and Clostridium perfringens challenge. In the first study, Zn proteinate had beneficial effects on the performance of chickens challenged with coccidia plus C. perfringens by enhancing intestinal integrity and partially attenuating the inflammatory response. In the second study, Zn proteinate lowered the expression of pro-inflammatory cytokines and modulated the ileal microbiota. Additionally, the poultry industry has used prophylactic concentrations of dietary Cu for its ability to improve feed conversion for a long time.Copper absorption occurs mainly in the duodenum of chickens and, therefore, injuries to the intestinal epithelium of duodenum would impair Cu absorption and decrease its tissue concentration. Although there is a lack of studies relating Mn supplementation and its different sources on the immune response against coccidiosis in poultry, it is likely that Mn is beneficial during enteric challenges due to its role in the production of mucopolysaccharides. Therefore, the proper evaluation of the role of minerals on mitigating the negative impact of coccidiosis in broilers must consider their properties in modulating the physiology, immunology, and the intestinal microbiota of the host during health and disease situation events.

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Section: Coppermentioning

confidence: 61%

Section: Coppermentioning

confidence: 99%

Influence of Dietary Zinc, Copper, and Manganese on the Intestinal Health of Broilers Under Eimeria Challenge

Bortoluzzi¹,

Vieira

Applegate

2020

Front. Vet. Sci.

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“…The addition of humic substances to the feed for quails (360; 480; 600 mg.kg -1 ) caused an increase in serum Zn (31.47; 35.79; 35.66 µmol.l -1 ) and a decrease in serum Cu (31.47; 35.79; 35.66 µmol.l -1 ) in three supplemented groups compared to the control broilers [4]. Blood and liver Cu concentrations are positively associated with the plasma ceruloplasmin concentration [2]. M i l l e r et al [14] observed the levels of trace elements in sea ducks' blood and found that Cu concentrations differed little among species, site, or age class (adult females versus ducklings), perhaps due to Cu being closely regulated in the blood.…”

Section: Resultsmentioning

confidence: 99%

Contents of Selected Elements in the Blood Serum of Broiler Chickens After Supplementation of Humic Substances

et al. 2022

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This study was conducted to determine the concentrations of mineral substances, such as: calcium (Ca), magnesium (Mg), copper (Cu), and zinc (Zn); in the blood serum of broiler chicks after supplementation of humic substances. Group 1 (G1) was supplemented with 0.7 % Humac Natur Mycosorb (HNMy); G2 with 0.7 % Humac Natur Monogastric (HNM); G3 with 0.3 % HNMy; and the control group (GC) received a basal diet without any supplements. In the G2 group, the serum Ca level increased slightly compared to the other experimental groups. A statistically significant decrease (P < 0.001) in the blood serum of Mg was detected in the broilers from group G2 (0.60 mmol.l−1) and G1 (P < 0.05; 0.68 mmol.l−1) in comparison to the GC. The Zn in the blood serum of broilers from group G2 (22.05 µmol.l−1) was significantly increased (P < 0.05) in broilers from group G2 in comparison to the control group (19.47 µmol.l−1) and G1 group (19.61 µmol.l−1). The serum Cu (12.72 µmol.l−1) was significantly increased (P < 0.001) in broilers from group G2 in comparison to the GC (10.28 µmol.l−1). In the group G1 there was a significant decrease (P < 0.05) in the level of the Cu in the blood serum (8.69 µmol.l−1) in comparison to the serum Cu in broilers from groups G3 (10.45 µmol.l−1) and G2 (12.72 µmol.l−1). The addition of Humac Natur Mycosorb (0.3 % and 0.7 %) in the feed caused a strong correlation in the blood serum between the Ca and Mg (r = 0.7494; r = 0.7648). The addition of 0.3 % Humac Natur Mycosorb in the feed caused a high negative correlation (r = –0.7078) in the blood serum between the Mg and Zn.

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“…The sample size of cows per treatment (high vs. low) was estimated to be 11, based on a 2-tailed test, with a difference of 30% between electron transport chain enzyme complex activities, with a power of 0.90 and an α of 0.05. Estimates of sample size were based on the cows available for the project and past studies, involving mitochondrial measurements (Acetoze et al, 2017;Niesen and Rossow, 2019), and the minimum sample size was 10 cows per treatment. To be included in the study, cows needed to be at a similar stage of lactation (70 ± 11 DIM) and were fed the same diet using Calan Broadbent Feeding System (American Calan Inc.).…”

Section: Animal Management and Housingmentioning

confidence: 99%

Peripheral blood mononuclear cell mitochondrial enzyme activity is associated with parity and lactation performance in early lactation Holstein dairy cows

Niesen

Genther-Schroeder²,

Bradley³

et al. 2022

Journal of Dairy Science

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Mitochondria are central to metabolism and are the primary energy producers for all biosynthesis, including lactation. The objectives of this study were to determine if high-and low-producing dairy cows exhibit differences in peripheral blood mononuclear cell mitochondrial enzyme activities of citrate synthase, complex I, complex IV, and complex V during early lactation and, thus, to determine whether those differences were related to differences in lactation performance in the dairy cow. Fifty-six Holstein cows were assigned to 1 of 4 groups: (1) primiparous high, (2) primiparous low, (3) multiparous high, or (4) multiparous low. Primiparous and multiparous cows were analyzed separately. Then, cows were divided into high or low production groups for each production parameter [peak milk, average milk, energy-corrected milk (ECM), fat-corrected milk (FCM), milk lactose, milk fat, milk protein, total solids (TS), solids-not-fat, feed efficiency, and somatic cell count (SCC)]. For all data analysis, production parameters are expressed as yields (kg/d) and SCC (10 3 cells/ mL). High and low production groups were defined by their respective mean production parameters for the 56 cows, with below average cows defined as low and above average cows defined as high. Whole blood samples were collected at one time point, approximately 70 d in milk at 0800 h, and processed for crude mitochondrial extracts from peripheral blood mononuclear cells to determine the activity rates of mitochondrial enzymes. Milk samples were collected 9 times (3 d, 3 times per d) during the week of blood collection and analyzed for major components (fat, protein, lactose, TS, and SCC). Multiparous cows had lower citrate synthase activity than primiparous cows across all production pa-rameters. High-producing cows had greater complex I activity for peak milk, milk yield, ECM, FCM, milk fat, TS, and feed efficiency, and greater complex V activity for ECM, FCM, milk lactose, milk fat, and TS across parities. These findings imply that the most influential respiratory chain enzymes on the level of milk production are those responsible for electron transport chain initialization and ATP production.

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Liver mitochondrial oxygen consumption and proton leak kinetics in broilers supplemented with dietary copper or zinc following coccidiosis challenge

Cited by 4 publications

References 14 publications

Influence of Dietary Zinc, Copper, and Manganese on the Intestinal Health of Broilers Under Eimeria Challenge

Influence of Dietary Zinc, Copper, and Manganese on the Intestinal Health of Broilers Under Eimeria Challenge

Contents of Selected Elements in the Blood Serum of Broiler Chickens After Supplementation of Humic Substances

Peripheral blood mononuclear cell mitochondrial enzyme activity is associated with parity and lactation performance in early lactation Holstein dairy cows

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