Liver perfusion in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI): comparison of enhancement in Gd-BT-DO3A and Gd-EOB-DTPA in normal liver parenchyma

Schalkx, Hanke J.; Stralen, Marijn van; Coenegrachts, Kenneth; Bosch, Maurice A.A.J. van den; Kessel, Charlotte S. van; Hillegersberg, Richard van; Erpecum, Karel J. van; Verkooijen, Helena M.; Pluim, Josien P. W.; Veldhuis, Wouter B.; Leeuwen, Maarten S. van

doi:10.1007/s00330-014-3275-x

Cited by 16 publications

(13 citation statements)

References 24 publications

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“…Second, cross-sectional imaging can reveal perfusion of different muscle groups within a same field of view and even reveal intramuscle heterogeneity of blood flow. Dynamic contrastenhanced (DCE) MR imaging (MRI) has been widely adopted as a clinical tool for assessing tissue perfusion in many organs (27,36,41,53) and in cancers (26,31,51). In skeletal muscle (2, 13, 15, 29, 30), several groups have explored potential value of DCE MRI in assessing PAD.…”

Section: Introductionmentioning

confidence: 99%

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Zhang

Layec

Hanrahan

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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Peripheral artery disease (PAD) in the lower extremities often leads to intermittent claudication. In the present study, we proposed a low-dose DCE MRI protocol for quantifying calf muscle perfusion stimulated with plantar flexion and multiple new metrics for interpreting perfusion maps, including the ratio of gastrocnemius over soleus perfusion (G/S; for assessing the vascular redistribution between the two muscles) and muscle perfusion normalized by whole body perfusion (for quantifying the muscle’s active hyperemia). Twenty-eight human subjects participated in this Institutional Review Board-approved study, with 10 healthy subjects ( group A) for assessing interday reproducibility and 8 healthy subjects ( group B) for exploring the relationship between plantar-flexion load and induced muscle perfusion. In a pilot group of five elderly healthy subjects and five patients with PAD ( group C), we proposed a protocol that measured perfusion for a low-intensity exercise and for an exhaustion exercise in a single MRI session. In group A, perfusion estimates for calf muscles were highly reproducible, with correlation coefficients of 0.90–0.93. In group B, gastrocnemius perfusion increased linearly with the exercise workload ( P < 0.05). With the low-intensity exercise, patients with PAD in group C showed substantially lower gastrocnemius perfusion compared with elderly healthy subjects [43.4 (SD 23.5) vs. 106.7 (SD 73.2) ml·min−1·100 g−1]. With exhaustion exercise, G/S [1.0 (SD 0.4)] for patients with PAD was lower than both its low-intensity level [1.9 (SD 1.3)] and the level in elderly healthy subjects [2.7 (SD 2.1)]. In conclusion, the proposed MRI protocol and the new metrics are feasible for quantifying exercise-induced muscle hyperemia, a promising functional test of PAD. NEW & NOTEWORTHY To quantitatively map exercise-induced hyperemia in calf muscles, we proposed a high-resolution MRI method shown to be highly reproducible and sensitive to exercise load. With the use of low contrast, it is feasible to measure calf muscle hyperemia for both low-intensity and exhaustion exercises in a single MRI session. The newly proposed metrics for interpreting perfusion maps are promising for quantifying intermuscle vascular redistribution or a muscle’s active hyperemia.

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Section: Introductionmentioning

confidence: 99%

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Zhang

Layec

Hanrahan

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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“…Since completion of this study, a multi-slice adaption of the Look-Locker FAIR ASL sequence has been developed ( Campbell-Washburn et al , 2013 ). Utilising the vessel-selective pseudo-continuous ASL sequences ( Dai et al , 2008 ) could provide a direct method for separating the arterial and venous contributions to the liver blood supply, from which response biomarkers such as the hepatic perfusion index, a measure of the relative contribution of the two supplies in individual metastases, could be evaluated to further probe tumour pathophysiology ( Cuenod et al , 2001 ; Schalkx et al , 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Acute changes in liver tumour perfusion measured non-invasively with arterial spin labelling

Ramasawmy

Campbell-Washburn

et al. 2016

Br J Cancer

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Background:Non-invasive measures of tumour vascular perfusion are desirable, in order to assess response to vascular targeting (or modifying) therapies. In this study, hepatic arterial spin labelling (ASL) magnetic resonance imaging (MRI) was investigated to measure acute changes in perfusion of colorectal cancer in the liver, in response to vascular disruption therapy with OXi4503.Methods:SW1222 and LS174T tumours were established in the liver of MF1 nu/nu mice via intrasplenic injection. Perfusion and R2* MRI measurements were acquired with an Agilent 9.4T horizontal bore scanner, before and at 90 min after 40 mg kg−1 OXi4503.Results:A significant decrease in SW1222 tumour perfusion was observed (−43±33%, P<0.005). LS174T tumours had a significantly lower baseline level of perfusion. Intrinsic susceptibility MRI showed a significant increase in R2* in LS174T tumours (28±25%, P<0.05). An association was found between the change in tumour perfusion and the proximity to large vessels, with pre-treatment blood flow predictive of subsequent response. Histological evaluation confirmed the onset of necrosis and evidence of heterogeneous response between tumour deposits.Conclusions:Hepatic ASL-MRI can detect acute response to targeted tumour vascular disruption entirely non-invasively. Hepatic ASL of liver tumours has potential for use in a clinical setting.

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“…3B). 36,39,42 After Gd-BOPTA injection, the peak of liver enhancement and SNR is during the portal phase, with a subsequent slow increase of liver parenchyma signal, reaching a plateau at 60 minutes and lasting for approximately 60 minutes, when liver enhancement starts to decrease. Thus, for Gd-BOPTA the optimal timing of the hepatospecific phase is within 60 minutes and 120 minutes (Fig.…”

Section: Liver Mri Protocolmentioning

confidence: 99%

Magnetic Resonanance Imaging of the Liver (Including Biliary Contrast Agents)—Part 2: Protocols for Liver Magnetic Resonanance Imaging and Characterization of Common Focal Liver Lesions

Agostini

Kircher

K.G

et al. 2016

Seminars in Roentgenology

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Liver perfusion in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI): comparison of enhancement in Gd-BT-DO3A and Gd-EOB-DTPA in normal liver parenchyma

Cited by 16 publications

References 24 publications

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Acute changes in liver tumour perfusion measured non-invasively with arterial spin labelling

Magnetic Resonanance Imaging of the Liver (Including Biliary Contrast Agents)—Part 2: Protocols for Liver Magnetic Resonanance Imaging and Characterization of Common Focal Liver Lesions

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