Liver regeneration after performing associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) is histologically similar to that occurring after liver transplantation using a small-for-size graft

Wakabayashi, T.; Tanaka, Kuniya; Shiozawa, Toshimitsu; Takahashi, Yuki; Tanabe, Mikiko; Matsuo, Keitaro

doi:10.1007/s00595-020-02097-1

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…The extended hepatectomy with the resection volume between 70% and 90% in rats is most widely used to model SFSS following either extended hepatectomy or reduced-size liver transplantation (Nacif et al 2015; Dahmen et al 2008; Wakabayashi et al 2021). Based on our previous study, 80% hepatectomy compromises liver function in rats without conferring mortality risk compared with 90% hepatectomy (Shi et al 2011).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Shi

Bai

Yan

et al. 2021

Preprint

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The regulation mechanism of small-for-size syndrome remains unclear. Thus, we aimed to analyze the molecular profiles following extended hepatectomy and identify the therapeutic target. Major hepatectomy and extended hepatectomy were performed in the rat model, and the remnant livers were obtained dynamically for the high-throughput transcriptome analysis to identify the differentially expressed genes (DEGs). The general framework for weighted gene co-expression network analysis (WGCNA) was employed to explore the expression patterns of DEGs. As result, WGCNA identified 10 distinct gene co-expression modules according to the correlation between module eigengene and different postoperative time-points. The magenta module (gene count: 289) and the lightcyan module (gene count: 484) were found positively correlated with major hepatectomy instead of extended hepatectomy. In the lightcyan module, peroxisome proliferator-activated receptor-α (PPARα) was selected and found the down-regulation in the remnant liver following extended (marginal) hepatectomy in rats and humans. Besides, administration of PPARα agonist attenuated hepatic inflammation injury while PPARα antagonist increased liver inflammation injury after extended hepatectomy in rats, marked by the significantly changed aminotransferases, tumor necrosis factor-α and interleukin-6 levels in the plasm, and histological Suzuki criteria. Consequently, DEGs and their molecular profiles after extended hepatectomy were identified, and PPARα might be a potential therapy target for small-for-size syndrome.

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Section: Methodsmentioning

confidence: 99%

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Shi

Bai

Yan

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The extended hepatectomy with the resection volume between 70% and 90% in rats is most widely used to model SFSS following either extended hepatectomy or reduced-size liver transplantation [13][14][15]. Based on our previous study, 80% hepatectomy compromises liver function in rats without conferring mortality risk compared with 90% hepatectomy [16].…”

Section: Development Of Partial Hepatectomy In Ratsmentioning

confidence: 99%

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Shi

Bai

Yan

et al. 2022

Preprint

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Background The regulation mechanism of post-operative hepatic failure and small-for-size syndrome remains unclear. Thus, we aimed to analyze the molecular profiles following extended hepatectomy and identify the therapeutic target. Methods Major hepatectomy and extended hepatectomy were performed in the rat model, and the remnant livers were obtained dynamically for the high-throughput transcriptome analysis to identify the differentially expressed genes (DEGs). The general framework for weighted gene co-expression network analysis (WGCNA) was employed to explore the expression patterns of DEGs. The expression and function of the selected DEG from the WGCNA was further verified following hepatectomy in the human and rat. Results DEGs after major hepatectomy and extended hepatectomy were detected by transcriptomics. WGCNA identified 10 distinct gene co-expression modules according to the correlation between module eigengene and different postoperative time-points. The magenta module (gene count: 289) and the lightcyan module (gene count: 484) were found positively correlated with major hepatectomy instead of extended hepatectomy. In the lightcyan module, peroxisome proliferator-activated receptor-α (PPARα) was selected and found the down-regulation in the remnant liver following extended (marginal) hepatectomy in rats and humans. Besides, administration of PPARα agonist attenuated hepatic inflammation injury while PPARα antagonist increased liver inflammation injury after extended hepatectomy in rats, marked by the significantly changed aminotransferases, tumor necrosis factor-α and interleukin-6 levels in the plasm, and histological Suzuki criteria. Conclusion DEGs and their molecular profiles after extended hepatectomy were identified, and PPARα could be a potential therapy target for small-for-size syndrome.

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“…6,7 The unique combination of portal vein deprivation and liver transection stimulates a complex pathophysiological regeneration pattern influenced by various factors. [8][9][10][11][12][13][14][15][16] Histology plays a pivotal role in liver surgery. Patients with abnormal liver parenchyma who undergo hepatectomy have worse postoperative outcomes.…”

mentioning

confidence: 99%

“…The major advantage of ALPPS is the reduction in drop-out rates (ie, progression to completion hepatectomy), particularly in colorectal liver metastases (CRLM), which is the most common indication 6,7 . The unique combination of portal vein deprivation and liver transection stimulates a complex pathophysiological regeneration pattern influenced by various factors 8–16 …”

mentioning

confidence: 99%

Liver Histology Predicts Liver Regeneration and Outcome in ALPPS

Lopez-Lopez,

Linecker,

Caballero-Llanes

et al. 2023

Annals of Surgery

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Background and Aims: Alterations in liver histology influence the liver´s capacity to regenerate, but the relevance of each of the different changes rapid liver growth induction is unknown. This study aimed to analyze the influence of the degree of histological alterations during the first and second stages on the ability of the liver to regenerate. Methods: This cohort study included data obtained from the International ALPPS Registry between November 2011 and October 2020. Only patients with colorectal liver metastases were included in the study. We developed a histological risk score based on histological changes (stages 1 and 2) and a tumor pathology score based on the histological factors associated with poor tumor prognosis. Results: In total, 395 patients were included. The time to reach stage 2 was shorter in patients with a low histological risk stage 1 (13 vs. 17 d, P˂0.01), low histological risk stage 2 (13 vs. 15 d, P˂0.01) and low pathological tumor risk (13 vs. 15 d, P˂0.01). Regarding interval stage, there was a higher inverse correlation in high histological risk stage 1 group compared to low histological risk 1 group in relation with future liver remnant body weight (r=−0.1 and r=−0.08, respectively), and future liver remnant (r=−0.15 and r=−0.06, respectively). Conclusion: ALPPS is associated with increased histological alterations in the liver parenchyma. It seems that the more histological alterations present and the higher the number of poor prognostic factors in the tumor histology, the longer the time to reach the second stage.

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Liver regeneration after performing associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) is histologically similar to that occurring after liver transplantation using a small-for-size graft

Cited by 4 publications

References 30 publications

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Liver Histology Predicts Liver Regeneration and Outcome in ALPPS

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