2003
DOI: 10.1097/01.sla.0000090449.87109.44
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Liver Resection as a Bridge to Transplantation for Hepatocellular Carcinoma on Cirrhosis

Abstract: LT after liver resection is associated with a higher operative mortality, an increased risk of recurrence, and a poorer outcome than primary LT. In addition, liver resection as a bridge to LT impairs the patient transplantability and the chance of long-term survival of cirrhotic patients with HCC. Primary LT should therefore remain the ideal choice of treatment of a cirrhotic patient with HCC, even when the tumor is resectable.

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Cited by 331 publications
(229 citation statements)
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“…For potential recipients with recurrent hepatocellular carcinoma and a poor liver function, the chance of a curative liver transplantation ought to be estimated. 37 This has to be interpreted with current opinions 37,38 and local results. 39 Continuity of care by the same team of surgeons is logical.…”
Section: Discussionmentioning
confidence: 99%
“…For potential recipients with recurrent hepatocellular carcinoma and a poor liver function, the chance of a curative liver transplantation ought to be estimated. 37 This has to be interpreted with current opinions 37,38 and local results. 39 Continuity of care by the same team of surgeons is logical.…”
Section: Discussionmentioning
confidence: 99%
“…200 Published series from the past two decades tend to provide perioperative mortality rates of under 15%, with the most recent predominantly falling in the range 2-8%. 193,194,199,[201][202][203][204][205][206][207][208][209][210][211][212][213] One UK unit has reported that, during their experience with OLT for small HCC from 1995 to 1999, there were four perioperative mortalities in 30 cases (13.3%).…”
Section: Perioperative Mortalitymentioning
confidence: 99%
“…A study based on analysis of the European Liver Transplant Registry indicated that HCC recurrence in patients who previously underwent liver resection would often present with multiple tumor nodules, and only 25% of patients with recurrent tumors fulfilled the Milan criteria (Mergental and Porte, 2010). Studies also indicated that liver transplant was only feasible in 23% of patients with recurrent HCC (Adam et al, 2003). Our clinical data show that in patients with recurrent HCC beyond the Milan criteria, the 3-year recurrence rate and overall survival rate after SLT are 86.1%, and 40.6%, respectively .…”
Section: Recurrent Hepatocellular Carcinomamentioning
confidence: 99%