Liver Specific Serum Micro RNA122 as a Prognostic Marker in Egyptian Patients with Liver Cirrhosis

Amin, MA; Fawzi, Mohamed; Sabri, D; Sedrak, Heba; Mausa, S

doi:10.17352/ahr.000008

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…In countries where viral hepatitis is a health burden, liver cirrhosis has become an important health problem 28. Liver cirrhosis is accompanied by RD, especially in advanced liver disease.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score

Bhatti

Tahir

Chaudhary

et al. 2019

BMJ Open Gastroenterol

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ObjectivesTo assess factors associated with renal dysfunction (RD) in hepatitis C virus (HCV) cirrhosis, correlate renal parameters with Child-Pugh score (CPS) and find a cut-off value of CPS to determine RD.Materials and methodsIt was a cross-sectional study that included 70 cases of liver cirrhosis secondary to HCV from a period of 6 months at Combined Military Hospital, Multan. Diagnosis of HCV was confirmed by serological assay and liver cirrhosis by ultrasonography. CPS was determined and lab reports were taken. Patients were divided into two groups as not having RD (serum creatinine≤1.5 mg/dL) and having RD (serum creatinine≥1.5 mg/dL). Estimated glomerular filtration rate (eGFR) was calculated by chronic kidney disease epidemiology collaboration (CKD-EPI) formula. Data were analyzed using SPSS V.23.0. χ2, Kruskal-Wallis test and Pearson coefficient of correlation were applied. ROC curve was drawn to evaluate cut-off value of CPS for the presence of RD. Level of significance was set at p<0.05.ResultsPatients with CP grade B or C develop RD as compared to patients with CP grade A (p=0.000). Mean age, urea, creatinine and eGFR varies significantly among patients who develop RD and patients who do not (p=0.02, p=0.000, p=0.000 and p=0.000, respectively). eGFR negatively correlates with CPS (r=−0.359, p=0.002). Creatinine, urea and ALBI score positively correlates with CPS (r=+0.417, p=0.000; r=+0.757, p=0.000; r=+0.362, p=0.002, respectively).ConclusionAscites and encephalopathy are associated with RD in HCV cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score

Bhatti

Tahir

Chaudhary

et al. 2019

BMJ Open Gastroenterol

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“…In previous studies [ 30 , 35 ], the serum levels of miR-122 in patients with hepatic decompensation were significantly lower compared to patients with compensated liver disease.…”

Section: Discussionmentioning

confidence: 94%

LncRNA HULC and miR-122 Expression Pattern in HCC-Related HCV Egyptian Patients

Gaber

Shaker

Younis

et al. 2022

Genes

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Hepatocellular carcinoma (HCC) is a highly prevalent malignancy. It is a common type of cancer in Egypt due to chronic virus C infection (HCV). Currently, the frequently used lab test is serum α-fetoprotein. However, its diagnostic value is challenging due to its low sensitivity and specificity. Genetic biomarkers have recently provided new insights for cancer diagnostics. Herein, we quantified Lnc HULC and miR-122 gene expression to test their potential in diagnosis. Both biomarkers were tested in the sera of 60 HCC patients and 60 with chronic HCV using real-time RT-PCR. miR-122 was highly expressed in HCV patients with a significant difference from the HCC group (p = 0.004), which points towards its role in prognosis value as a predictor of HCC in patients with chronic HCV. HULC was more highly expressed in HCC patients than in the HCV group (p = 0.018), indicating its potential use in screening and the early diagnosis of HCC. The receiver operating characteristic (ROC) curve analysis showed their reliable sensitivity and specificity. Our results reveal that miR-122 can act as a prognostic tool for patients with chronic HCV. Furthermore, it is an early predictor of HCC. LncRNA HULC can be used as an early diagnostic tool for HCC.

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The role of microRNAs on the pathogenesis, diagnosis and management of portal hypertension in patients with chronic liver disease

Selvakumar

Preethi

Veeraiyan

et al. 2022

Expert Review of Gastroenterology & Hepatology

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Liver Specific Serum Micro RNA122 as a Prognostic Marker in Egyptian Patients with Liver Cirrhosis

Abstract: Introduction: Recent research has shown that microRNAs (miRNA) are emerging as important regulators of cellular differentiation. The miR-122 accounts for approximately 70% of all miRNAs in the liver so its presence in the serum is highly indicative of liver processes.

Cited by 5 publications

References 32 publications

Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score

Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score

LncRNA HULC and miR-122 Expression Pattern in HCC-Related HCV Egyptian Patients

The role of microRNAs on the pathogenesis, diagnosis and management of portal hypertension in patients with chronic liver disease

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