Liver stiffness accuracy by MR elastography in histologically proven non-alcoholic fatty liver disease patients: a Spanish cohort

Romero, Carmen Lara; Liang, Jia-Xu; Lizaranzazu, Isabel Fernández; Ampuero, Javier; Castell, Javier; Alba, Carmen Del Prado; Pascual, Inmaculada Domínguez; Romero‐Gómez, Manuel

doi:10.17235/reed.2022.8777/2022

Cited by 2 publications

(6 citation statements)

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“…Recent advancements in genomic profiling have identified specific mutations driving HCC. Personalized therapies targeting these mutations, such as tyrosine kinase inhibitors, promise to improve outcomes and extend survival in HCC patients [ 30 ]. A compelling success story revolves around the use of sorafenib in HCC.…”

Section: Reviewmentioning

confidence: 99%

“…A compelling success story revolves around the use of sorafenib in HCC. By identifying specific mutations in the tumor, clinicians can tailor sorafenib treatment to target these mutations, leading to improved response rates and prolonged survival in select patient populations [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

“…Personalizing immunosuppression involves tailoring the choice and dosage of medications based on individual immune profiles. This approach has led to the successful management of autoimmune liver diseases, allowing patients to achieve remission with fewer side effects and a better quality of life [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

“…Genomic and proteomic approaches are at the forefront of identifying novel biomarkers. By decoding the molecular tapestry of liver diseases, researchers aim to discover unique signatures that can serve as early indicators, allowing for timely intervention and personalized treatment [ 30 ]. Liquid biopsies, which involve analyzing circulating biomarkers in bodily fluids, offer a non-invasive window into liver health.…”

Section: Reviewmentioning

confidence: 99%

“…MicroRNAs, which regulate gene expression, are emerging as potential biomarkers. Altered microRNA signatures have been linked to various liver diseases, offering a glimpse into their diagnostic potential and the intricate molecular changes occurring in diseased livers [ 30 ]. While the promise of novel biomarkers is exciting, translating these discoveries into clinical practice comes with challenges.…”

Section: Reviewmentioning

confidence: 99%

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Diagnosis and Treatment of Liver Disease: Current Trends and Future Directions

Wazir,

Abid,

Essani

et al. 2023

Cureus

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This narrative review delves into the intricate landscape of liver diseases, providing a comprehensive background of the diverse conditions that afflict this vital organ. Liver diseases, ranging from viral hepatitis and non-alcoholic fatty liver disease (NAFLD) to cirrhosis and hepatocellular carcinoma (HCC), pose significant global health challenges. Understanding these diseases' multifaceted origins and progression is pivotal for developing effective diagnostic and therapeutic strategies. The epidemiology and etiology of liver diseases emphasize the global impact of viral hepatitis, with hepatitis B and C as significant contributors. Concurrently, the rising prevalence of NAFLD, linked to lifestyle factors and metabolic syndrome, underscores the intricate relationship between modern living and liver health. Chronic liver diseases often evolve insidiously, progressing from inflammation to fibrosis and, ultimately, to cirrhosis - a stage characterized by irreversible scarring and compromised function. The heightened risk of HCC in advanced liver disease stages further underscores the urgency of effective diagnostic and therapeutic interventions. The evolving landscape of non-invasive diagnostic tools is explored for their role in enabling early detection and accurate staging of liver diseases. In the realm of treatment, there is a continuous transition toward personalized medicine, customized to suit the unique profiles of individual patients. This shift encompasses a broad spectrum, ranging from personalized pharmacological interventions to lifestyle modifications and surgical options. Delving into innovative therapies, such as gene editing and immunomodulation, offers a glimpse into the promising future directions that have the potential to redefine the landscape of liver disease diagnosis and treatment.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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