“…However, in advanced hepatic failure, highly protein-bound or lipophilic compounds such as octanoic acid, some amino acids and other organic acids, neurosteroids, bilirubin and substances resulting from inflammation syndrome that are probably responsible for breakdown of the blood-brain barrier, need additional elimination procedures [4]. Albumin dialysis has been described as enabling this elimination, resulting in neurological improvement [10,11]. At present, in cases of severe liver failure and overt encephalopathy, albumin dialysis seems to be the only feasible treatment that can eliminate the abovementioned compounds and improve cerebral edema [6], although in the last few years the bioartificial liver has become the main topic for investigation.…”