Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF

Langenberg, Marlies H.G.; Nijkamp, Maarten W.; Roodhart, Jeanine M.L.; Snoeren, Nikol; Tang, Terence; Shaked, Yuval; Hillegersberg, Richard van; Witteveen, Petronella O.; Vermaat, Joost S.P.; Kranenburg, Onno; Kerbel, Robert S.; Medema, René H.; Rinkes, Inne H.M. Borel; Voest, Emile E.

doi:10.4161/cbt.9.9.11551

Cited by 17 publications

(13 citation statements)

References 46 publications

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“…The exact mechanism is still not fully clarified. Recently Langenberg et al [85] showed that major liver surgery could mobilize HSCs into the liver where they differentiated into HPCs. This effect could last up to 24 h in response to elevated levels of granulocyte colony-stimulating factor (G-CSF), indicating that G-CSF may have a significant role in the activation of progenitor cells of hematopoietic origin [86] .…”

Section: Angogenesismentioning

confidence: 99%

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Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications. Key words: Hepatocellular carcinoma; Colorectal cancer; Recurrence; Liver regeneration; Hepatic progenitor cell; Epithelial to mesenchymal transition Core tip: The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue, and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors.

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Section: Angogenesismentioning

confidence: 99%

“…Several studies have reported that liver surgery and acute liver injury can lead to mobilization of progenitor cells, both after partial hepatectomy in general and in HCC patients [75,[83][84][85][86] . The exact mechanism is still not fully clarified.…”

Section: Angogenesismentioning

confidence: 99%

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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“…Inflammatory cells and bone marrowderived progenitor cells (BMDPCs) homing to injured tissue may promote local tumor growth and metastasis by secreting growth factors, cytokines and matrix-remodeling enzymes. [16][17][18] Such cells may also play a role in mediating chemotherapy resistance and in suppressing antitumor immunity. 16 One of the hallmarks of injured tissue is oxygen deprivation (hypoxia), caused by decreased tissue perfusion.…”

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confidence: 99%

Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells

Govaert

Emmink²,

Nijkamp³

et al. 2014

Annals of Surgery

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“…18 Circulating angiogenic factors in colorectal cancer patients with liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy. New treatments should therefore aim to decrease the risk of liver metastasis, by reducing the population of EPCs and VEGF levels, through immunomodulatory or antiangiogenic treatment.…”

mentioning

confidence: 99%