Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization

Wang, Aohua; Fan, Weiwei; Yang, Tiantian; He, Shuqing; Yang, Yiwei; Yu, Miaorong; Li, Fan; Zhu, Quanlei; Guo, Shiyan; Zhu, Chunliu; Gan, Yong

doi:10.1002/adfm.201910168

Cited by 39 publications

(31 citation statements)

References 56 publications

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“…S5). The UiO-68-NH 2 NPs exhibited a high LC of 33 weight % (wt %) at the feeding ratio of 4:1, higher than most of the INS nanocarriers being reported (table S1) (29,51). The mass loss was also observed to determine the LC of the UiO-68-NH 2 -based nanosystem by thermogravimetric analysis (TGA), which was consistent with the above results (fig.…”

Section: Preparation and Characterization Of Nmof-based Protein Deliv...supporting

confidence: 88%

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

et al. 2022

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Oral protein delivery is considered a cutting-edge technology to improve patients’ quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH 2 ) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery. The UiO-68-NH 2 nanocarrier with proper pore size achieved high insulin loading while protecting insulin from acid and enzymatic degradation. Through receptor-mediated transcellular pathway, the transferrin-coated nanoparticles realized efficient transport across the intestinal epithelium and controlled insulin release under physiological conditions, leading to a notable hypoglycemic effect and a high oral bioavailability of 29.6%. Our work demonstrates that functional metal-organic framework nanoparticles can protect proteins from the gastric environment and overcome the intestinal barrier, thus providing the possibility for oral biomacromolecule delivery.

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Section: Preparation and Characterization Of Nmof-based Protein Deliv...supporting

confidence: 88%

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

et al. 2022

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“…These nanosystems were able to release the encapsulated insulin in hyperglycemic conditions based on GOx-induced H 2 O 2. These orally-delivered, liver targeting systems were successful in regulating insulin delivery in rat models, and could be translated favorably into clinical praxis [ 179 ]. Lectin is a group of naturally glucose- and mannose-binding protein moieties.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…Reproduced with permission. [ 178 ] Copyright 2020, WILEY‐VCH E) Schematic of the glucose‐responsive oral insulin delivery system with glucose‐sensitive HA shell for postprandial glycemic regulation. HA indicates hyaluronic acid.…”

Section: Nanomaterials For Diabetes Prevention and Therapymentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization

Cited by 39 publications

References 56 publications

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

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