2010
DOI: 10.4049/jimmunol.184.supp.135.2
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Liver Th1 cells drive the accumulation of Myeloid Derived Suppressor Cells during acute hepatitis in an IFN-γ-dependent manner. (135.2)

Abstract: Th1 responses in the liver are the basis for parenchymal damage in autoimmune hepatitis (AIH). The cellular pathways that inhibit liver Th1 responses are not well understood. BALB/c mice lacking TGF-β1 spontaneously and rapidly develop acute Th1 cell-mediated necroinflammatory hepatitis. Liver damage requires interferon gamma (IFN-γ) production by CD4+ T cells. We hypothesized that the Th1 response would also activate pathways capable of down-regulating T cell responses, specifically, a myeloid derived suppres… Show more

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