Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

Bellamy, Christopher; DiMartini, Andrea; Ruppert, K.; Jain, Ashok; Dodson, Forrest; Torbenson, Michael; Starzl, Thomas E.; Fung, John J.; Demetris, Anthony J.

doi:10.1097/00007890-200108270-00010

Cited by 166 publications

(88 citation statements)

References 72 publications

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“…A higher incidence of lung cancer post-LTx with poorer prognosis has been reported by Jiménez et al 44 and others. 41,42,45 In contrast, Haagsma and others did not find any cases of oropharyngeal cancer in their series, 20,24,27,[46][47][48] and only 1 case of oropharyngeal and lung cancer was observed in the present study by Åberg and coworkers, 36 which included 54 cases of alcoholic cirrhosis.…”

Section: Brief Description Of the Differences In The Incidence Of Varcontrasting

confidence: 75%

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

2008

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Section: Brief Description Of the Differences In The Incidence Of Varcontrasting

confidence: 75%

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

2008

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“…ETOH is a common indication for LT and is associated with very good post-LT outcomes if the patient remains abstinent from further alcohol use. 13 One recent large study showed that survival rates following LT in patients with ETOH are similar to the rates for patients with other causes of cirrhosis (89% versus 84% and 84% versus 81% at 3 and 5 years, respectively). 21 Our results show that although there was a trend toward lower patient survival in the NASH group compared to the ETOH group, the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 91%

“…Recurrence of the primary disease and/or cardiovascular complications related to the underlying metabolic syndrome may affect the outcome of NASH patients after LT. Alcoholic cirrhosis (ETOH) is a wellestablished indication for LT and is associated with an excellent outcome if the patient remains abstinent from further alcohol use. 13 In this study, using LT for ETOH as a comparator, we assessed the outcomes of LT in patients with cryptogenic cirrhosis with the NASH phenotype.…”

mentioning

confidence: 99%

Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease

Bhagat¹,

Mindikoğlu²,

Nudo³

et al. 2009

Liver Transpl

165

142

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Nonalcoholic steatohepatitis (NASH) is becoming a common cause of liver cirrhosis requiring liver transplantation (LT). Cardiovascular complications related to metabolic syndrome and NASH recurrence in the transplanted liver may affect the outcome of LT in these patients. We compared the outcomes of LT for NASH cirrhosis and alcoholic cirrhosis (ETOH) in a large transplant center. A retrospective chart review was performed for all patients who underwent LT for cryptogenic cirrhosis with the NASH phenotype (the NASH group) or ETOH (the ETOH group) at the University of Miami from January 1997 to January 2007. There was no significant difference in survival between the NASH and ETOH groups, despite a trend toward lower survival in the former (P ϭ 0.1699). Sepsis was the leading cause of posttransplant death in both groups, and it was followed by cardiovascular causes in the NASH group (26% versus 7% in the ETOH group, P ϭ 0.21) and malignancies in the ETOH group (29% versus 0% in the NASH group, P ϭ 0.024). Recurrent steatohepatitis (33% versus 0%, P Ͻ 0.0001) and acute rejection (41% versus 23%, P Ͻ 0.023) were significantly more frequent in the NASH group than in the ETOH group. There was no difference in graft failure between the groups (24% in the NASH group versus 18% in the ETOH group, P ϭ 0.3973).In conclusion, despite a numerical trend favoring the ETOH group, there were no statistically significant differences in posttransplant survival and cardiovascular mortality between the NASH and ETOH groups. Acute rejection and recurrent steatohepatitis were significantly more frequent in the NASH group but did not lead to higher rates of retransplantation. Liver

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“…In addition, other studies have reported an increased incidence of the development of chronic hepatitis and allograft failure in HCVpositive patients transplanted for alcoholic cirrhosis. [24][25] It is unclear at this stage how pretransplant alcohol-related liver disease could promote subsequent allograft fibrosis in HCV-infected recipients, and it will be important in future studies to obtain a detailed history of alcohol intake from these patients after transplantation.…”

Section: Discussionmentioning

confidence: 99%

Liver transplantation for HCV-associated liver cirrhosis: Predictors of outcomes in a population with significant genotype 3 and 4 distribution

Zekry

Whiting

Crawford

et al. 2003

Liver Transplantation

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End-stage liver disease associated with hepatitis C virus (HCV) infection is now the leading indication for liver transplantation in adults. However, reinfection of the graft is universal. We aimed to determine predictors of outcome of HCV-liver transplant recipients in the Australian and New Zealand communities. The following variables were analysed: demographic factors, coexistent pathology at the time of transplantation, HCV genotype, and donor age. Outcomes measures were: 1. mortality; 2. development of HCV-related complications, which were stage 3 or 4 fibrosis, or mortality from HCV-related graft failure, or both. Between January 1989 and December 30, 1999, 182 patients were transplanted for HCV-associated cirrhosis. The median follow-up period was 4 years (range, 0 to 13 years). Genotype data were available on 157 patients. The distribution of genotypes among the 157 patients was as follows: 36 (23%) genotype 1a, 30 (19%) genotype 1b, 4 (9%) genotype 1, 17 (11%) genotype 2, 41 (26%) genotype 3a, and 16 (10%) genotype 4. Eight (5%) patients were HCV-polymerase chain reaction (PCR)-negative (but HCV-antibody-positive). Donor age and genotype 4 were associated with an increased risk of retransplantation or death (P < .001 and .05, respectively). Meanwhile, donor age, genotype 4, and pretransplant excess alcohol were risk factors for the development of HCV-related complications (P ‫؍‬ .004, .008, and .02, respectively). In contrast, patients with genotype 3a were less likely to develop HCV-related complications (P ‫؍‬ .05). In a population of HCV liver transplant recipients with a heterogeneous genotype distribution, donor age, and genotype 4, were predictors of a worse outcome, whereas genotype 3 was associated with a more favorable outcome. (Liver Transpl 2003;9:339-347.)

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Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

Abstract: of cytokine-elicited nitric oxide synthesis in rat liver macrophages.

Cited by 166 publications

References 72 publications

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease

Liver transplantation for HCV-associated liver cirrhosis: Predictors of outcomes in a population with significant genotype 3 and 4 distribution

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