llumination On The Structure And Characteristics Of Entamoeba Histolytica Genome.

Abstract

Entamoeba histolytica, likes other Organismes, is characterized by diversity and heterogeneity in its genetic content, which is one of the most paramount reasons for survival, and the increase in susceptibility to infection. Non-condensation of chromosomes during the process of cell division and the ambiguity of the chromosomal ploidy makes predicting the exact chromosomal numeral difficult. Genes distributed across 14 chromosomes as well as many extra-chromosome elements. Most Genes compose of one axon only, with Introns in 25% of Genes. This genome is characterized by the presence of Polymorphic internal repeat regions, and several gene families, one of these large families encoding Transmembrane kinas, Cysteine protease (CP), SREHP protein, and others.

A review of entamoebahistolytica genome, virulence factors, phylogenetic tree and treatment

“…The optimal antimicrobial activity of neutrophils and other macrophages is based on the production of a wave of superoxide anions (O_2^-)by activating the enzymeoxidases NADPH and then this O_2^is processed to give hydrogen peroxide (H2O2) and hydroxyl radical (OH), Hypochlorous acid (HOCl) and oxidized nitric oxide derivatives (NO^.) such as peroxynitrite(ONOO^-) [67]. Thus defense strategies against oxidative and nitrosative stresses include detoxification enzymes and repair systems that enable cells to resist ROS and RNS [65].…”