LMO1 Gene Polymorphisms Reduce Neuroblastoma Risk in Eastern Chinese Children: A Three-Center Case-Control Study

He, Lili; Zhu, Jinhong; Han, Fei; Tang, Yu; Zhou, Chunlei; Dai, Jincheng; Wang, Yizhen; Zhou, Haixia; He, Jing; Wu, Haiyan

doi:10.3389/fonc.2018.00468

Cited by 11 publications

(23 citation statements)

References 40 publications

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“…Details on participants may be found in previous studies. 16 , 30 There were no significant differences between neuroblastoma patients and healthy controls in age (p = 0.823) and sex (p = 0.610).…”

Section: Resultsmentioning

confidence: 84%

“…A total of 313 neuroblastoma patients and 762 healthy controls from the eastern Chinese population were included in the case-control study. 16 , 30 , 44 All participants were unrelated Chinese Han children. The study was approved by each participating hospital Institutional Review Board.…”

Section: Methodsmentioning

confidence: 99%

“…Genetic factors play a critical role in neuroblastoma development. 9 Genome-wide association studies (GWASs), a powerful tool discovering causal genes and revealing susceptibility variants for diseases, 10 have identified some neuroblastoma susceptibility polymorphisms, locating in TP53 , 11 BARD1 , 12 HACE1 , 13 NEFL , 14 LMO1 , 15 , 16 and LIN28B 17 genes. For example, BARD1 rs1048108 and rs17489363 polymorphisms were reported to be associated with neuroblastoma susceptibility.…”

Section: Introductionmentioning

confidence: 99%

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Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

Zhou

Wang

et al. 2021

Molecular Therapy - Oncolytics

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Neuroblastoma is a common childhood malignancy. Nucleotide excision repair (NER) polymorphisms have been shown to influence cancer susceptibility by modifying DNA repair efficiency. To investigate the association of NER gene polymorphisms with neuroblastoma risk, we constructed a three-center case-control study. A total of 19 candidate single-nucleotide polymorphisms (SNPs) in NER genes were analyzed. Odds ratios (ORs) and 95% confidential intervals (CIs) were calculated to evaluate the associations. We identified five independent SNPs that were significantly associated with neuroblastoma risk, including XPA rs1800975 (dominant model: adjusted OR = 0.73, 95% CI = 0.55–0.98, p = 0.033), XPA rs3176752 (recessive model: adjusted OR = 2.78, 95% CI = 1.12–6.91, p = 0.028), XPD rs3810366 (dominant: adjusted OR = 1.44, 95% CI = 1.05–1.97, p = 0.022; recessive: adjusted OR = 1.58, 95% CI = 1.18–2.11, p = 0.002), XPD rs238406 (dominant: adjusted OR = 0.64, 95% CI = 0.48–0.84, p = 0.002; recessive: adjusted OR = 0.67, 95% CI = 0.48–0.94, p = 0.021), and XPG rs2094258 (recessive: adjusted OR = 1.44, 95% CI = 1.03–2.04, p = 0.036). Stratified analysis was carried out. Furthermore, these findings were strengthened by false-positive report probability (FPRP) analysis and expression quantitative trait loci (eQTL) analysis. In conclusion, our study indicates that five SNPs in NER genes are correlated with neuroblastoma susceptibility in the eastern Chinese population, providing novel insight into the genetic underpinnings of neuroblastoma. However, further large-scale studies are required to verify these findings.

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Section: Resultsmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

Zhou

Wang

et al. 2021

Molecular Therapy - Oncolytics

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“…Participants were recruited from three hospitals: Children's Hospital of Nanjing Medical University (158 cases and 426 controls, Jiangsu province, China) [39], Anhui Provincial Children's Hospital (119 cases and 264 controls, Anhui province, China) [40], and The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (36 cases and 72 controls, Wenzhou area) [41,42]. A total of 313 cases and 762 controls were enrolled for the case-control study (Supplementary Table S1).…”

Section: Study Subjectsmentioning

confidence: 99%

Association of miR-146a, miR-149 and miR-196a2 polymorphisms with neuroblastoma risk in Eastern Chinese population: a three-center case–control study

et al. 2019

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Neuroblastoma is one of the most common malignancy in childhood, which originates from the developing sympathetic nervous system. Single nucleotide polymorphisms (SNPs) in primary miRNA (pri-miRNA) have shown to associate with cancer susceptibility, including neuroblastoma. Three precursor miRNA (pre-miRNA) SNPs (pre-miR-146a rs2910164, pre-miR-149 rs2292832 and pre-miR-196a2 rs11614913) were found to contribute to pathogenesis of various diseases. Here, to evaluate the association among these three pre-miRNA SNPs and neuroblastoma susceptibility in Eastern Chinese children, we carried out a three-center case–control study involving 312 neuroblastoma cases and 762 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association of these three polymorphisms with neuroblastoma risk. However, no significant association was observed among these three SNPs and neuroblastoma susceptibility, in either overall or subgroups analysis by tumor sites, gender and age. Further larger studies consisting of diverse ethnic populations are required to clarify the associations among these three pre-miRNAs polymorphisms and neuroblastoma risk.

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“…Ultimately, 9 published articles 14,20,[27][28][29][30][31][32][33] that met our inclusion criteria were identified: 12 case-control studies on rs110419 and rs4758051 polymorphisms, 8 studies on rs10840002 and rs204938 polymorphisms, and three studies on the rs2168101polymorphism were also included in our meta-analysis. The Figure 1B-D illustrates the position of the analysed polymorphisms within the LMO1 gene.…”

Section: Study Characteristicsmentioning

confidence: 99%

LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta‐analysis of case‐control studies

Hashemi

Sarabandi

Karami

et al. 2019

J Cellular Molecular Medi

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Neuroblastoma (NB), a neuroendocrine tumour, is one of the most prevalent cancers in children. The link between LMO1 polymorphisms and NB has been investigated by several groups, rendering inconclusive results. Here, with this comprehensive systematic review and up‐to‐date meta‐analysis, we aim to distinctively elucidate the possible correlation between LMO1 polymorphisms and NB susceptibility. Eligible studies were systematically researched and identified using PubMed, Web of Science and Scopus databases up to 10 February 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the associations. Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models. In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model. In contrast, the rs204938 polymorphism showed a positive association with NB susceptibility in allele genetic models. In summary, our meta‐analysis is the first to provide clear evidence of an association between specific polymorphisms of LMO1 and susceptibility to NB. Of note, additional larger well‐designed studies would be helpful to further evaluate and confirm this association.

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LMO1 Gene Polymorphisms Reduce Neuroblastoma Risk in Eastern Chinese Children: A Three-Center Case-Control Study

Cited by 11 publications

References 40 publications

Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

Association of miR-146a, miR-149 and miR-196a2 polymorphisms with neuroblastoma risk in Eastern Chinese population: a three-center case–control study

LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta‐analysis of case‐control studies

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