LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway

Guo, Linqi; Zhou, Yu; Chen, Ying; Sun, Huawei; Wang, Yue; Qu, Yikun

doi:10.1016/j.biopha.2018.04.015

Cited by 37 publications

(31 citation statements)

References 39 publications

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“…It has been elucidated that IGFIR activates the Hedgehog signaling pathway in growth-plate (GP) chondrocytes [35]. Research conducted by Guo et al revealed that the activation of the Hedgehog signaling pathway is involved in proliferation, migration and EMT progression of cholangiocarcinoma cells [36].…”

Section: Discussionmentioning

confidence: 99%

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

et al. 2020

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Background: Accumulating amount of evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) in tumor pathogenesis. However, the roles of long non coding RNAs (lncRNAs) in the lncRNA-related ceRNA network of intrahepatic cholangiocarcinoma (ICC) still remain enigmatic. The current study aims to identify prognostic factors in the lncRNA-related ceRNA network of ICC. Methods: The transcriptome sequencing data of lncRNAs, messenger RNA (mRNA) and microRNA (miR) were downloaded from the SRA and TCGA databases. Differentially expressed lncRNAs (DElncRNAs), DEmiRs and DEmRNAs were identified and adopted to construct an lncRNA-miR-mRNA ceRNA network. ICC-associated DEmRNAs were adopted to construct the protein-protein interaction (PPI) network. The expression of the top 6 genes in the hub module was validated with mRNA transcriptome sequencing data and ICC-related gene expression dataset GSE45001, followed by GO and KEGG pathway enrichment analysis. The relationship between the hub gene-associated ceRNA network and the overall survival of patients with ICC was predicted by conducting a Kaplan-Meier survival analysis. Results: Sixty co-expressed DEmRNAs were identified in the ceRNA network. The top 6 hub genes consisted of downregulated FOS, IGF2, FOXO1 and NTF3, upregulated IGF1R, and insignificantly downregulated HGF in ICC tissues, when compared to that of normal adjacent tissues, followed by the successful construction of lncRNA-miR-hub network consisting of 86 ceRNA modules. MME-AS1 and hsa-miR-182 were associated with overall survival in ICC patients. FOS, IGF1R, IGF2, FOXO1, and NTF3 might target "TGF-β signaling pathway", "the hedgehog signaling pathway", "retinol metabolism", or "type II diabetes mellitus" pathways respectively. Conclusion: These results indicate that FOS, IGF1R, IGF2, FOXO1, and NTF3 were useful prognostic factors in determining the prognosis of patients with ICC.

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Section: Discussionmentioning

confidence: 99%

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

et al. 2020

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“…Studies from different groups have confirmed that the dysregulation of lncRNA expression is closely related to the biological behavior of CCA cells. Upregulation of these lncRNAs, including KCNQ1OT1 [48], LMCD1-AS1 [37], TP73-AS1 [22], SNHG1 [49], SOX2-OT [39], LINC01410 [50], ASAP1-IT1 [51], DANCR [52], FLVCR1-AS1 [53], NNT-AS1 [54], RMRP [55], CCAT2 [56], HOTAIR [57], LINC01296 [58], LOXL1-AS1 [59], NEAT1 [60], PVT1 [43], HEIH [61], LINC01061 [62], may promote the migration and invasion of CCA cells, . On the other hand, the downregulation of several lncRNAs plays the same role in CCA cells including LINC01714 [63], FENDRR [64], MEG3 [65], and MIR22HG [66].…”

Section: Promotion Of the Migration And Invasion Of Cca Cellsmentioning

confidence: 99%

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

Yang

Deng

et al. 2020

Cancer Communications

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Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numerous long noncoding RNAs (lncRNAs) have been identified as crucial players in the development of various cancers, including CCA. Abnormally expressed lncRNAs in CCA, regulated by some upstream molecules, significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms, including interactions with functional proteins, participation in competing for endogenous RNA (ceRNA) regulatory networks, activation of cancer‐related signaling pathways and epigenetic modification of gene expression. Furthermore, several lncRNAs are closely associated with the clinicopathological features of CCA patients, and are promising biomarkers for diagnosing and prognostication of CCA. Some of these lncRNAs play an important role in chemotherapy drug resistance. In addition, lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors, such as cholestatic liver diseases. In view of the difficulty of diagnosing CCA, more attention should be paid to detectable lncRNAs in the serum or bile. This review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of lncRNAs. Moreover, we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.

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“…These lncRNAs may promote proliferation, migration and invasion of CCA cells including lncRNA AFAP1-AS1, ASAP1-IT1, CCAT1, CCAT2, H19, HULC, LINC01296, ENST0000058480.1, ENST00000517758.1, MALAT1, NEAT1, PANDAR, SNHG1, Sox2ot, SPRY4-IT1, TP73-AS1 etc. [23,29,30,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. In ICC, LncRNA CPS1-IT1 and TLINC are highly expressed [33,50].…”

Section: Lncrna Promotes Cca Proliferation Migration and Invasionmentioning

confidence: 99%

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development

Jiang¹,

Ling²

2019

J. Cancer

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Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasion and inhibit apoptosis of CCA. Moreover, lncRNA is negatively correlated with the prognosis of CCA. LncRNA may contribute to the development of CCA via modulating gene transcription, sponging microRNA, regulating CCA-related signaling pathways or protein expression. LncRNA is thought to be potential diagnostic markers and therapeutic targets for CCA.

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LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway

Cited by 37 publications

References 39 publications

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development

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