LncRNA DLEU2 aggravates the progression of hepatocellular carcinoma through binding to EZH2

Guo, Yongjian; Bai, Man; Li, Lin; Huang, Jingjun; An, Yongcheng; Liang, Li; Liu, Yaohong; Huang, Wensou

doi:10.1016/j.biopha.2019.109272

Cited by 46 publications

(45 citation statements)

References 22 publications

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“…Some studies have showed that lncRNA DLEU2 interacted with EZH2 to promote the proliferation, migration and invasion of hepatocellular carcinoma, thus accelerating the malignant progression of hepatocellular carcinoma [32]. In gastric cancer, lncRNA UCA1 enhanced the translation of cyclin D1 via recruiting EZH2 and further precipitated the proliferation and cell cycle progression of gastric cancer [33].…”

Section: Resultsmentioning

confidence: 99%

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Gao

Nie

Zhang

et al. 2020

Preprint

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Background: Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains unclear. It’s meaningful to explore lncRNAs signature for providing prognostic value of EC. Methods：The differentially expressed lncRNAs and their prognostic values in EC were investigated based on The Cancer Genome Atlas (TCGA) database; the transcriptional factors (TFs), the competing endogenous RNA (ceRNA) mechanism, functional regulatory network and immune infiltration of RP11-89K21.1 and RP11-357H14.17 were further explored by various bioinformatics tools and databases. Results: We firstly identified high expression of RP11-89K21.1 and RP11-357H14.17 were closely associated with shorten overall survival (OS) and poor prognosis in patients with EC. We also elucidated the networks of transcription factor and co-expression genes associated with RP11-89K21.1 and RP11-357H14.17. Furthermore, the ceRNA network mechanism was successfully constructed through 2 lncRNAs (RP11-89K21.1 and RP11-357H14.17), 11 miRNAs and 183 mRNAs. Functional enrichment analysis revealed that the targeting genes of RP11-89K21.1 and RP11-357H14.17 were strongly associated with microRNAs in cancer, vessel development, growth regulation, growth factor and cell differentiation, and involved in pathways including pathways in cancer, microRNAs in cancer and apoptotic signaling pathway. Conclusions: We demonstrated for the first time that RP11-89K21.1 and RP11-357H14.17 may play crucial roles in the occurrence, development and malignant biological behavior of EC, and can be regarded as potential prognostic biomarkers for EC.

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Section: Resultsmentioning

confidence: 99%

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Gao

Nie

Zhang

et al. 2020

Preprint

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“…Accumulating evidence indicates that the elevated expression of DLEU2 is a frequent even in malignant tumors [4][5][6][7][8][9] and associated with unfavorable prognosis in NSCLC and EC. 4,8 However, the clinical significance of DLEU2 in GC is elusive.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated expression of DLEU2 was linked to pathological stage and worse survival in GC. Previous reports showed that DLEU2 can act as an oncogene [4][5][6][7] or tumor suppressive factor in cancers. 10,11 In accordance with the studies, [4][5][6][7] We found that ectopic expression of DLEU2 enhanced the growth of GC cells and knockdown of DLEU2 counteracted these effects.…”

Section: Discussionmentioning

confidence: 99%

lncRNA DLEU2 accelerates gastric cancer growth by downregulating miR-30a-5p

Zhu

Zou

2020

Eur J Inflamm

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Introduction: lncRNA DLEU2 has been indicated to act a crucial role in the bioprocess of cancer. But, the role and molecular mechanisms of lncRNA DLEU2 in gastric cancer (GC) remain unknown. Methods: The correlation of DLEU2 or miR-30a-5p with the clinical parameters and outcomes of GC patents was implemented by TCGA cohort. Cell viability and invasion were estimated by MTT and Transwell assays. The interplay between DLEU2 and miR-30a-5p was confirmed by a luciferase report assay. The effects of DLEU2 on miR-30a-5p or MMP2/9 were detected by qRT-PCR and Western blot. Results: We found that the enhanced expression of DLEU2 was linked to the pathological stage and poor survival in GC patients. Overexpressing DLEU2 prompted the cell proliferation and invasion of AGS cells, but silencing DLEU2 weakened these effects in MKN-28 cells. In addition, DLEU2 could negatively modulate and be bound with miR-30a-5p, which could counteract DLEU2-caused cell proliferation. High expression of miR-30a-5p was linked to a favorable survival in patients with GC. Conclusion: Our findings suggested that lncRNA DLEU2 could favor the growth of GC by downregulating miR-30a-5p.

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“…We found that EZH2 was the common transcriptional regulator of RP11-89K21.1 and RP11-357H14.1 in endometrial carcinoma with AnnoLnc, Moreover, EZH2 was positively correlated with the expression of RP11-89K21.1 and RP11-357H14.1. Some studies have showed that lncRNA DLEU2 interacted with EZH2 to promote the proliferation, migration and invasion of hepatocellular carcinoma, thus accelerating the malignant progression of hepatocellular carcinoma [31] . In gastric cancer, lncRNA UCA1 enhanced the translation of cyclin D1 via recruiting EZH2 and further precipitated the proliferation and cell cycle progression of gastric cancer [32] .…”

Section: Correlation Between the Expression Of Rp11-mentioning

confidence: 99%

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Gao

Nie

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains unclear. It’s meaningful to explore lncRNAs signature for providing prognostic value of EC. Methods：The differentially expressed lncRNAs and their prognostic values in EC were investigated based on The Cancer Genome Atlas (TCGA) database; the transcriptional factors (TFs), the competing endogenous RNA (ceRNA) mechanism, functional regulatory network and immune infiltration of RP11-89K21.1 and RP11-357H14.17 were further explored by various bioinformatics tools and databases. Results: We first identified high expression of RP11-89K21.1 and RP11-357H14.17 were closely associated with shorten overall survival (OS) and poor prognosis in patients with EC. We also elucidated the networks of transcription factor and co-expression genes associated with RP11-89K21.1 and RP11-357H14.17. Furthermore, the ceRNA network mechanism was successfully constructed through 2 lncRNAs (RP11-89K21.1 and RP11-357H14.1), 11 miRNAs and 183 mRNAs. Functional enrichment analysis revealed that the targeting genes of RP11-89K21.1 and RP11-357H14.17 were strongly associated with microRNAs in cancer, vessel development, growth regulation, growth factor and cell differentiation, and involved in pathways including cytokine-mediated signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway and apoptotic signaling pathway. Moreover, RP11-89K21.1 and RP11-357H14.17 were correlated with immune infiltration including CD8_T cell, CD4_Tcell, Macrophage and Neutrophil. Conclusions: We demonstrated for the first time that RP11-89K21.1 and RP11-357H14.17 may play crucial roles in the occurrence, development and malignant biological behavior of EC, and can be regarded as potential prognostic biomarkers for EC.

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LncRNA DLEU2 aggravates the progression of hepatocellular carcinoma through binding to EZH2

Cited by 46 publications

References 22 publications

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

lncRNA DLEU2 accelerates gastric cancer growth by downregulating miR-30a-5p

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

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