LncRNA KLK8 modulates stem cell characteristics in colon cancer

Wang, Kuangjing; Song, Wei; Shen, Yingzhou; Wang, Haitao; Fan, Zhining

doi:10.1016/j.prp.2021.153437

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…Thus, understanding the biology of CSC in CC is of great clinical significance. 6 Recent findings indicate that the role of the abnormal expression of miRNAs is related to the regula- tion of CSC properties, such as asymmetric cell division, tumorigenicity, and drug resistance. 7,8 CSCs usually share specific stemness-related markers, such as CD44 and CD133, but they can differ depending on the cancer type.…”

Section: Discussionmentioning

confidence: 99%

“…Despite their potential clinical significance, how intrinsic CSC properties are regulated at the molecular level needs to be better understood. 6 Therefore, there is an urgent need to understand the molecular mechanisms controlling CSC populations and functions to develop effective therapies to eradicate recurrences, which are a real threat to complete cancer cures. MicroRNAs (miRNAs) are small noncoding RNAs that function as negative regulators of mRNAs.…”

Section: Introductionmentioning

confidence: 99%

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Ten-Year Recurrence Outcomes in Early Stage and Early Onset Colon Cancer and the Expression Profiles of MicroRNAs and Cancer Stem Cell Markers in These Tumors

Aksoy

Tunca

Yılmazlar

et al. 2023

Online Türk Sağlık Bilimleri Dergisi

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Abstract Objective: We hypothesized that microRNAs (miRNAs) may be involved in tumor development by critically regulating cancer stem cell (CSC) markers in early stages of colon cancer (eCC). The aim of this study was to determine the expression profiles of miRNAs in CSC-positive eCC patients and to examine their associations with recurrence. Materials and Methods: We analyzed CD133, LGR5 and SOX2 expression profiles to determine CSC status in 30 eCC specimens. Then, using the results of RT2 miRNA PCR custom arrays, we evaluated the expression profiles of 38 miRNAs in CSC-positive eCC patients. Results: Recurrence occurred in 5 patients within 10 years after surgery. We determined down-regulation of miR-125b and up-regulation of miR-135b were significant in CSC-positive eCC patients (P= 0.021, P= 0.001, respectively). We found that low expression of miR-125b was associated with recurrence in eCC (P= 0.0022). Conclusion: We suggest that recurrence might be prevented by increasing expression of miR-125b in eCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ten-Year Recurrence Outcomes in Early Stage and Early Onset Colon Cancer and the Expression Profiles of MicroRNAs and Cancer Stem Cell Markers in These Tumors

Aksoy

Tunca

Yılmazlar

et al. 2023

Online Türk Sağlık Bilimleri Dergisi

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“…Knockdown of LOCCS reduced cell proliferation, invasion, migration, and tumorigenesis in vivo . Recently, lncRNA KLK8 has been reported that was upregulated and positively correlated with the stemness gene in CRC[ 107 ]. Wu et al [ 108 ] found that lncRNA SLCO4A1-AS1 could bind with miR-150-3p to elevate the expression of SLCO4A1 and the stemness of CRC.…”

Section: Lncrnasmentioning

confidence: 99%

Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Chao¹,

Wang²,

Chern³

et al. 2022

WJGO

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The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.

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“…Inhibition of this miRNA by Lnc34a allows cancer stem cells to maintain their identity through cell divisions. Additional lncRNAs that have been described as regulators of stemness in colorectal cancer are lncRNA-TUG 1 [ 124 ], lncRNA-BCAR4 [ 125 ], lncRNA SLCO4A1-AS1 [ 126 ], and lncRNA KLK8 [ 127 ].…”

Section: The Role Of Lncrnas In the Regulation Of The Stem Phenotype ...mentioning

confidence: 99%

Regulation of the Cancer Stem Phenotype by Long Non-Coding RNAs

Gutierrez-Cruz

Maldonado

Meléndez-Zajgla

2022

Cells

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Cancer stem cells are a cell population within malignant tumors that are characterized by the ability to self-renew, the presence of specific molecules that define their identity, the ability to form malignant tumors in vivo, resistance to drugs, and the ability to invade and migrate to other regions of the body. These characteristics are regulated by various molecules, such as lncRNAs, which are transcripts that generally do not code for proteins but regulate multiple biological processes through various mechanisms of action. LncRNAs, such as HOTAIR, H19, LncTCF7, LUCAT1, MALAT1, LINC00511, and FMR1-AS1, have been described as key regulators of stemness in cancer, allowing cancer cells to acquire this phenotype. It has been proposed that cancer stem cells are clinically responsible for the high recurrence rates after treatment and the high frequency of metastasis in malignant tumors, so understanding the mechanisms that regulate the stem phenotype could have an impact on the improvement of cancer treatments.

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LncRNA KLK8 modulates stem cell characteristics in colon cancer

Cited by 10 publications

References 27 publications

Ten-Year Recurrence Outcomes in Early Stage and Early Onset Colon Cancer and the Expression Profiles of MicroRNAs and Cancer Stem Cell Markers in These Tumors

Ten-Year Recurrence Outcomes in Early Stage and Early Onset Colon Cancer and the Expression Profiles of MicroRNAs and Cancer Stem Cell Markers in These Tumors

Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Regulation of the Cancer Stem Phenotype by Long Non-Coding RNAs

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