lncRNA ROR and miR-125b Predict the Prognosis in Heart Failure Combined Acute Renal Failure

Abstract

Objective. To elucidate the correlation between expression levels of long noncoding RNA (lncRNA) ROR and microRNA-125b (miR-125b) with the prognosis in heart failure (HF) patients combined acute renal failure (ARF). Methods. HF patients combined ARF ( n = 90 ) and healthy controls ( n = 90 ) in the same period were included in our hospital from April 2016 to December 2018. Every subject was followed up for 24 months. Serum levels of lncRNA ROR and miR-125b were detected, and their expression correlation was analyzed by Pearson correlation test. Receiver operating characteristic (ROC) curves were depicted for assessing the sensitivity and specificity of lncRNA ROR and miR-125b in diagnosing HF combined ARF. Results. lncRNA ROR was upregulated in serum of HF patients combined ARF, and its level was positively correlated to NYHA classification. miR-125b displayed an opposite trend. In serum samples of HF combined ARF, expression level of lncRNA ROR was negatively related to that of miR-125b. Diagnostic potentials of lncRNA ROR and miR-125b in HF combined ARF were confirmed by ROC curve analyses (lncRNA ROR: AUC = 0.9199 , cutoff value = 5.595 , sensitivity = 92.22 % , and specificity = 73.33 % ; miR-125b: AUC = 0.8509 , cutoff value = 2.290 , sensitivity = 81.11 % , and specificity = 74.44 % ). After 2-year follow-up, 16 cases were dead. Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b. Conclusions. Serum level of lncRNA ROR is upregulated, and miR-125b is downregulated in HF patients combined ARF. Their levels are linked to NYHA classification, which can be utilized as prognostic biomarkers in HF combined ARF.

Long non-coding RNA SNHG7 serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after percutaneous coronary intervention

“…In this research, the high expression of SNHG7 was closely associated with the increase in Gensini scores, indicating that SNHG7 might have a relationship with the severity of ACS. The abnormally expression lncRNAs is observed as a predictor for the prognosis of cardiovascular illnesses [ 23 , 24 ]. For instance, lncRNA-Ang362 is correlated with the poor overall outcome of patients with coronary heart disease after PCI [ 25 ].…”

The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy

“…A number of lncRNAs, miRNAs, and mRNAs are tested to be differentially expressed in the serum of patients with cardiac diseases, nominating them as circulating disease markers (Li et al 2018;Xue et al 2022;Ying et al 2022). Hard-done work of our peers have reported that the aberrant expression of lncRNAs in hypertrophic heart, such as MIAT, RMRP, and Ahit (Zhou et al 2018;Yu et al 2020;…”

lncRNA LEF1-AS1 Acts as a Novel Biomarker and Promotes Hypopharyngeal Squamous Cell Carcinoma Progression and Metastasis by Targeting the miR-221-5p/GJA1 Axis

“…Recently, long noncoding RNAs (lncRNAs) which are identified as nonprotein-coding RNAs with over 200 nucleotides length have been revealed to play pivotal roles in molecular diagnosis and pathogenesis in almost all kinds of diseases including tumorigenesis and metastasis of cancers [3][4][5]. In HSCC, it has been proven that lncRNA HOXA11-AS contributed to the proliferation and migration via sponging and negatively regulation of miR-155 [6].…”