LncRNA XIST Promotes Migration and Invasion of Papillary Thyroid Cancer Cell by Modulating MiR-101-3p/CLDN1 Axis

Du, Yu; Liang, Yan; Cao, Yan; Liu, Le; Li, Jian; Shi, Guangqing

doi:10.1007/s10528-020-09985-8

Cited by 26 publications

(16 citation statements)

References 17 publications

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“…Also, it is revealed that the down-regulation of XIST can inhibit the development of non-small cell lung cancer [ 35 ]. This non-coding RNA also can promote the invasion and migration of papillary thyroid cancer cells [ 36 ] and pancreatic cancer [ 37 ]. About the proven role of XIST in the BC, Xing F et al at 2018 showed that the loss of XIST can promote the brain metastasis of BC by activating MSN-c-Met and reprogramming the microglia exosomal miRNA [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

NEAT1 can be a diagnostic biomarker in the breast cancer and gastric cancer patients by targeting XIST, hsa-miR-612, and MTRNR2L8: integrated RNA targetome interaction and experimental expression analysis

et al. 2022

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Background The most frequent malignancy in women is breast cancer (BC). Gastric cancer (GC) is also the leading cause of cancer-related mortality. Long non-coding RNAs (lncRNAs) are thought to be important neurotic regulators in malignant tumors. In this study, we aimed to evaluate the expression level of NEAT1 and the interaction of this non-coding RNA with correlated microRNAs, lncRNAs, and mRNAs or protein coding genes, experimentally and bioinformatically. Methods For the bioinformatics analyses, we performed RNA-RNA and protein–protein interaction analyses, using ENCORI and STRING. The expression analyses were performed by five tools: Microarray data analysis, TCGA data analysis (RNA-seq, R Studio), GEPIA2, ENCORI, and real-time PCR experiment. qRT-PCR experiment was performed on 50 GC samples and 50 BC samples, compared to adjacent control tissue. Results Based on bioinformatics and experimental analyses, lncRNA NEAT1 have a significant down-regulation in the breast cancer samples with tumor size lower than 2 cm. Also, it has a significant high expression in the gastric cancer patients. Furthermore, NEAT1 have a significant interaction with XIST, hsa-miR-612 and MTRNR2L8. High expression of NEAT1 have a correlation with the lower survival rate of breast cancer samples and higher survival rate of gastric cancer patients. Conclusion This integrated computational and experimental investigation revealed some new aspects of the lncRNA NEAT1 as a potential prognostic biomarker for the breast cancer and gastric cancer samples. Further investigations about NEA1 and correlated mRNAs, lncRNAs, and microRNAs – specially the mentioned RNAs in this study – can lead the researchers to more clear information about the role of NEAT1 in the breast cancer and gastric cancer.

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Section: Discussionmentioning

confidence: 99%

NEAT1 can be a diagnostic biomarker in the breast cancer and gastric cancer patients by targeting XIST, hsa-miR-612, and MTRNR2L8: integrated RNA targetome interaction and experimental expression analysis

et al. 2022

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“…Recently, XIST overexpression was also reported in PTC [84][85][86], where its higher levels are correlated with larger tumor size and advanced TNM stages. Moreover, overall survival is significantly lower in patients expressing high XIST levels [84].…”

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 90%

“…Functional studies have also been performed to validate the potential role of XIST overexpression in thyroid carcinogenesis. One study [86] reported that XIST promotes the migration and invasion of PTC cells by sponging miR-101-3p, which, in turn, targets the CLDN1 gene that codes for claudin-1, a tight junction protein associated with cancer cell migration and invasion (Figure 3B) [86]. Another study [84] demonstrated that XIST depletion leads to a decreased cancer cell proliferation associated with a reduction in MET protein levels through sponging miR-34a, which is able to inhibit MET protein synthesis.…”

Section: The Lncrna X Inactive Specific Transcript (Xist)mentioning

confidence: 99%

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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Among the thyroid neoplasias originating from follicular cells, we can include well-differentiated carcinomas, papillary (PTC) and follicular (FTC) thyroid carcinomas, and the undifferentiated anaplastic (ATC) carcinomas. Several mutations in oncogenes and tumor suppressor genes have already been observed in these malignancies; however, we are still far from the comprehension of their full regulation-altered landscape. Even if only 2% of the human genome has the ability to code for proteins, most of the noncoding genome is transcribed, constituting the heterogeneous class of noncoding RNAs (ncRNAs), whose alterations are associated with the development of several human diseases, including cancer. Hence, many scientific efforts are currently focused on the elucidation of their biological role. In this review, we analyze the scientific literature regarding the involvement of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and pseudogenes in FTC, PTC, and ATC. Recent findings emphasized the role of lncRNAs in all steps of cancer progression. In particular, lncRNAs may control progression steps by regulating the expression of genes and miRNAs involved in cell proliferation, apoptosis, epithelial–mesenchymal transition, and metastatization. In conclusion, the determination of the diagnosis, prognosis, and treatment of cancer based on the evaluation of the ncRNA network could allow the implementation of a more personalized approach to fighting thyroid tumors.

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“…Moreover, XIST acted as an upregulated lncRNA in liver cancer to promote liver cancer cell growth and metastasis [25] . In addition, XIST could also facilitate the migration and invasion of papillary thyroid cancer cells [26] . By contrast, downregulation of XIST was observed in ovarian cancer cells and tissues, and XIST suppressed ovarian cancer cell proliferation and inversely promoted cell apoptosis [27] .…”

Section: Discussionmentioning

confidence: 99%