LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

Liu, Yifan; Han, Yongdian; Zhang, Yanhua; Lv, Tongtong; Peng, Xiaochun; Huang, Jinlong

doi:10.3389/fimmu.2023.1067520

Cited by 13 publications

(9 citation statements)

References 128 publications

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“…Notably, these cells were not recognized by canonical myeloid cell markers. These clusters were annotated as myeloid-derived suppressor cells based on the upregulation of some markers including Colony Stimulating Factor 3 Receptor(CSF3R) (44, 45), Nicotinamide Phosphoribosyltransferase(NAMPT) (46, 47), and nuclear paraspeckle assembly transcript 1 (NEAT1) (48, 49). The suppressive nature of MDSCs is in accordance with the obtained results suggestive of the negative association of canonical neutrophil functions including neutrophil migration, neutrophil-mediated immunity, neutrophil degranulation, and neutrophil activation involved in immune response with the MDSCs function (50).…”

Section: Discussionmentioning

confidence: 99%

Correlation of myeloid-derived suppressor cell expansion with upregulated transposable elements in severe COVID-19 unveiled in single-cell RNA sequencing reanalysis

Farahmandnejad,

Mosaddeghi,

Dorvash

et al. 2023

Preprint

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Some studies investigated the potential role of transposable elements (TEs) in COVID-19 pathogenesis and complications. However, to the best of our knowledge, there is no study to examine the possible association of TEs expression in cell functions and its potential role in COVID-19 immune response at the single-cell level. In this study, we reanalyzed single-cell RNA seq data of bronchoalveolar lavage (BAL) samples obtained from six severe COVID-19 patients and three healthy donors to assess the probable correlation of TE expression with the immune responses induced by the SARS-CoV-2 virus in COVID-19 patients. Our findings indicated that the expansion of myeloid-derived suppressor cells (MDSCs (may be a characteristic feature of COVID-19. Additionally, a significant increase in TEs expression in MDSCs was observed. This upregulation of TEs in COVID-19 may be linked to the adaptability of these cells in response to their microenvironments. Furthermore, it appears that the identification of overexpressed TEs by Pattern recognition receptors (PRRs) in MDSCs may enhance the suppressive capacity of these cells. Thus, this study emphasizes the crucial role of TEs in the functionality of MDSCs during COVID-19.

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Section: Discussionmentioning

confidence: 99%

Correlation of myeloid-derived suppressor cell expansion with upregulated transposable elements in severe COVID-19 unveiled in single-cell RNA sequencing reanalysis

Farahmandnejad,

Mosaddeghi,

Dorvash

et al. 2023

Preprint

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“…In the context of cancer, MDSCs are abnormally produced and recruited into the TME to aid in establishing an immunosuppressive microenvironment that facilitates tumor immune escape ( 71 ). MDSCs are closely connected to the prognosis of patients with LC ( 72 ). There is increasing evidence that MDSCs are involved in the development of LC and may be used to predict the efficacy of immune checkpoint blockade (ICB) treatments ( 73 ).…”

Section: Overview Of Tumor Immune Microenvironment and Lung Cancermentioning

confidence: 99%

A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer

Yao,

Liang,

Liu

et al. 2024

Front. Immunol.

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Lung cancer (LC) produces some of the most malignant tumors in the world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component of the tumor microenvironment (TME), are critical in tumor development, immune escape, and drug resistance. The TIME is composed of various immune cells, immune cytokines, etc, which are important biological characteristics and determinants of tumor progression and outcomes. In this paper, we reviewed the recently published literature and discussed the potential uses of natural products in regulating TIME. We observed that a total of 37 natural compounds have been reported to exert anti-cancer effects by targeting the TIME. In different classes of natural products, terpenoids are the most frequently mentioned compounds. TAMs are one of the most investigated immune cells about therapies with natural products in TIME, with 9 natural products acting through it. 17 natural products exhibit anti-cancer properties in LC by modulating PD-1 and PD-L1 protein activity. These natural products have been extensively evaluated in animal and cellular LC models, but their clinical trials in LC patients are lacking. Based on the current review, we have revealed that the mechanisms of LC can be treated with natural products through TIME intervention, resulting in a new perspective and potential therapeutic drugs.

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“…Genomic localization and abundance of lncRNAs was examined using the program Circos (56). The lncRNAs were subdivided into five categories according to their class code generated by StringTie: (i) a transfrag falling entirely within a reference intron…”

Section: Localization Of Lncrnas On Genomementioning

confidence: 99%

Global Profiling of Differentiating Macrophages Identifies Novel Functional Long Non-coding RNAs Regulating Polarization and Innate Immune Responses

Valverde

Naqvi

2023

Preprint

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Macrophages (Mφ) are functionally dynamic immune cells that bridge innate and adaptive immune responses. However, the underlying epigenetic mechanisms that control the macrophage plasticity and innate immune functions are not well-elucidated. Here we performed transcriptome profiling of differentiating M1Mφ and M2Mφ and identified thousands of previously known and novel lncRNAs. We characterized three Mφ-enriched lncRNAs (LRRC75A-As1, GAPLINC and AL139099.5) with novel functions in Mφ differentiation, polarization and innate immunity. Knockdown of LRRC75A-As1, and GAPLINC downregulated Mφ differentiation markers CDw93 and CD68, and skewed macrophage polarization by decreasing M1 markers but had no significant impact on M2 markers. LRRC75A-As1, and GAPLINC RNAi in Mφ attenuated bacterial phagocytosis, antigen processing and inflammatory cytokine secretion supporting their functional role in potentiating innate immune functions. Mechanistically, lncRNA knockdown perturbed the expression of multiple cytoskeleton signaling thereby impairing Mφ migration suggesting their critical role in regulating macrophage polarity and motility. Together, our results show that Mφ acquire a unique repertoire of lncRNAs to shape differentiation, polarization and innate immune functions.

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LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

Cited by 13 publications

References 128 publications

Correlation of myeloid-derived suppressor cell expansion with upregulated transposable elements in severe COVID-19 unveiled in single-cell RNA sequencing reanalysis

Correlation of myeloid-derived suppressor cell expansion with upregulated transposable elements in severe COVID-19 unveiled in single-cell RNA sequencing reanalysis

A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer

Global Profiling of Differentiating Macrophages Identifies Novel Functional Long Non-coding RNAs Regulating Polarization and Innate Immune Responses

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