lncRNAs: Insights into their function and mechanics in underlying disorders

Li, X; Wu, Zhiqiang; Fu, Xiaobing; Han, Weidong

doi:10.1016/j.mrrev.2014.04.002

Cited by 207 publications

(165 citation statements)

References 214 publications

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“…LncRNAs use various mechanisms to execute their functions, such as epigenetic, transcriptional, and post-transcriptional regulation as well as regulation of microRNAs (miRNAs) [12]. Our data also showed that LINC00707 is mainly located in the cytoplasm (see online suppl.…”

Section: Discussionmentioning

confidence: 54%

“…As an increased number of functions for non-coding RNAs (ncRNAs) are being indentified, short ncRNAs (<200 nt) and long ncRNAs (>200 nt) have gained attention [9, 11]. Among them, lncRNAs can regulate transcription networks at multiple levels through their limited protein coding ability [12]. Although lncRNAs were previously regarded as “transcriptional noise”, they are now considered as key regulators of physiological processes and disorders including cancer [11, 13].…”

Section: Introductionmentioning

confidence: 99%

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The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

Zou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Lung cancer (LC) is a serious disease with high morbidity and mortality. Long noncoding RNAs (lncRNAs) have garnered attention because they participate in diverse human disorders, including cancer. Our study examined the long intergenic noncoding RNA 00707 (LINC00707). The effects of LINC00707 on lung adenocarcinoma (LAD) and molecular mechanisms are unclear. This study is aimed to investigate the role of LINC00707 in the malignant processes of LAD. Methods: Quantitative reverse transcription PCR (qRT-PCR) was used to examine the expression level of LINC00707 in tissues and cell lines. The association of LINC00707 expression and postoperative prognosis was analyzed by the Kaplan-Meier method and log-rank test. Cell proliferation was evaluated in vitro and in vivo. Transwell assays were performed to examine cell migration. Cell cycle and apoptosis was determined by flow -cytometric and western blot analyses. Microarray analysis was conducted to screen for the downstream target gene Cdc42 of LINC00707, which was identified by qRT-PCR, functional analysis, and rescue experiment. Results: The expression level of LINC00707 was clearly upregulated in LAD tissues compared to that in corresponding normal tissues. Its overexpression was related to advanced TNM stage, larger tumor size, lymphatic metastasis, and poor prognosis. Functional assays revealed that LINC00707 knockdown repressed LAD cell proliferation both in vitro and in vivo. This process may involve the inducing of G1 arrest and apoptosis. Moreover, cell migration was impaired after LINC00707 inhibition. Microarray analysis and rescue assays suggested that Cdc42 is an important target gene involved in the carcinogenesis of LINC00707. Conclusions: In summary, LINC00707 is a noncoding oncogene that exerts important regulatory functions in LAD, suggesting its potential as a biomarker in the prognosis and treatment of LAD.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

Zou

et al. 2018

Cell Physiol Biochem

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“…Reports indicate the role of lnRNAs in various post translational modifications. Their active participation in regulatory functions like disruption of translation, regulation of mRNA stability or transcriptional control, indicates the possible widespread functional significance of lnRNAs in gene regulation (Fatica and Bozzoni, 2015;Kung et al, 2013;Li et al, 2014;Singh and Prasanth, 2013). In the present study, we show the existence of Bmznf-2 5 0 UTR mediated negative regulation of this gene via a lnRNA(s)/unknown piRNA(s) or a regulatory protein that is involved in the probable suppression of the BmZNF-2 protein levels/activity.…”

Section: 0 Utr Based Bmznf-2 Negative Regulationsupporting

confidence: 54%

Role of Bmznf-2, a Bombyx mori CCCH zinc finger gene, in masculinisation and differential splicing of Bmtra-2

Gopinath

Arunkumar

Mita

et al. 2016

Insect Biochemistry and Molecular Biology

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“…Knockdown of IL1␤-eRNA and IL1␤-RBT46 together in activated cells specifically reduces the mRNA and protein levels of IL1-␤ and CXCL8, complying with their functional archetype as eRNAs (43,48,49).…”

Section: Lncrnas As Enhancers Of the Inflammatory Responsementioning

confidence: 83%

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

Mathy

Chen

2017

Journal of Biological Chemistry

213

162

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Edited by George M. Carman Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. lncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and time-dependent fashion. Here, we will review recent literature regarding the role of lncRNAs in transcriptional control of inflammatory responses. Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies.Because of the potentially destructive nature of the inflammatory response, the expression of inflammation-related genes is finely regulated at multiple levels, including transcription, mRNA processing, translation, phosphorylation, and degradation. Transcription represents an essential, and often the most important, regulatory determinant of the inflammation process. Many signaling pathways and transcription factors are involved in the inflammatory response, including the transcription factor nuclear factor-B (NF-B), 2 MAPK, and JAK/ STAT pathways, together controlling a multitude of inflammatory response genes (1, 2). Upon activation, these pathways directly activate and induce the expression of a limited set of transcription factors that promote the transcription of inflammatory genes. Whereas the mechanisms of initial activation and subsequent nuclear translocation of associated transcription factors for these signaling pathways are well-characterized, how the transcription of inflammatory genes is finely controlled in the nucleus to ensure that each individual gene is transcribed at the "right" place at the "right" time remains elusive. Perhaps this can be best represented by the inflammatory transcription induced by NF-B. The NF-B signaling cascade can be activated by inflammatory signals, including LPS, TNF-␣, IL-1␤, and reactive oxygen species, among others; many Toll-like receptors (TLRs) also activate NF-B (3-8).Prior to an activating signal, NF-B dimers are sequestered in the cytoplasm and held inactive by association with I B proteins (9). Activating stimuli cause I B degradation (10, 11), and consequently, free NF-B dimers translocate to the nucleus, bind to B sites, and promote gene transcription (12). Common targets of NF-B include inflammatory cytokines, chemokines, adhesion molecules, cytoprotective proteins, and proteins regulating cell differentiation, proliferation, and survival (13,14). In addition to its initial cytoplasmic activation, both the recruitment of NF-B to target genes in the nuclei and NF-B-induced transcriptional events after recruitment are finely controlled events to ensure proper transactivation of NF-B target genes (15). Indeed, several waves of gene transcription have been demonstrated in macrophages following LP...

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lncRNAs: Insights into their function and mechanics in underlying disorders

Cited by 207 publications

References 214 publications

The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

Role of Bmznf-2, a Bombyx mori CCCH zinc finger gene, in masculinisation and differential splicing of Bmtra-2

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

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