Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium

Yılmaz, Eren; Türk, Serbülent

doi:10.1007/s11696-021-02045-4

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…This is further discussed in the future outlook section (Combinatorial material approaches for a wide-range of applications) . Another approach is to directly load antibiotics into the sodium titanate structure, Yilmaz and Türk [280]. They demonstrated that following the NaOH treatment (10 M, 60°C, 24 h) of pure Ti plates, a gentamicin sulphate solution (50 mg mL −1 ; a broad-spectrum aminoglycoside antibiotic, which targets both Gram-positive and -negative bacteria) could be used to load the titanate surface.…”

Section: Modifiable Titanate Structures Based On Ion-exchangeability ...mentioning

confidence: 99%

Developing alkaline titanate surfaces for medical applications

Wadge

McGuire

Thomas

et al. 2023

International Materials Reviews

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Improving the surface of medical implants by plasma spraying of a hydroxyapatite coating can be of critical importance to their longevity and the patient's convalescence. However, residual stresses, cracking, undesired crystallisation and delamination of the coating compromise the implants lifetime. A promising alternative surface application is an alkali-chemical treatment to generate bioactive surfaces, such as sodium and calcium titanate and their derivatives. Such surfaces obviate the need for high temperatures and resulting micro-crack formation and potentially improve the bioactive and bone integration properties through their nanoporous structures. Also, metallic ions such as silver, gallium and copper can be substituted into the titanate structure with the potential to reduce or eliminate the infections. This review examines the formation and mechanisms of bioactive/antibacterial alkaline titanate surfaces, their successes and limitations, and explores the future development of implant interfaces via multifunctional titanate surfaces on Ti-based alloys and on alternative substrate materials.

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Section: Modifiable Titanate Structures Based On Ion-exchangeability ...mentioning

confidence: 99%

Developing alkaline titanate surfaces for medical applications

Wadge

McGuire

Thomas

et al. 2023

International Materials Reviews

View full text Add to dashboard Cite

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Bioactive apatite–wollastonite glass ceramics coating on metallic titanium for biomedical applications: effect of boron

Yılmaz,

Türk,

Semerci

et al. 2023

J Biol Inorg Chem

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Development of dual-effect AW/Ag/CHI bioactive and antibacterial coating for orthopedic implant surfaces

Türk,

Yılmaz,

Semerci

et al. 2024

J Therm Anal Calorim

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Titanium implants, which are widely used in orthopedic implant applications, require surface treatments due to their low osteoinduction properties and the risk of postoperative infection. In this study, apatite wollastonite (AW)-based coatings with chitosan (CHI) and silver (Ag) added were applied to the titanium surface using dip coating and drop casting techniques. The obtained coating surfaces were characterized by FESEM, EDS, XRD, FTIR, and TGA–DSC. Biomineralization behaviors were examined by immersing the resulting coatings in simulated body fluid with pH 7.2–7.4. The antibacterial activities of the coatings obtained using S. aureus and E. coli bacterial colonies were examined. Following the successful coating of AW nanoparticles on the Ag and CHI implant substrate, the Ca/P ratio of the coated surface was obtained as 1.4–1.92% after the biomineralization process performed at 37° for 7 days. Ag particles were successfully distributed homogeneously with a 40–50-nm diameter in Ag-doped coatings. It was concluded that the successfully produced composite coating with bioactive and antibacterial properties is a suitable candidate material for metallic implant surfaces. Graphical abstract

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Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium

Cited by 3 publications

References 36 publications

Developing alkaline titanate surfaces for medical applications

Developing alkaline titanate surfaces for medical applications

Bioactive apatite–wollastonite glass ceramics coating on metallic titanium for biomedical applications: effect of boron

Development of dual-effect AW/Ag/CHI bioactive and antibacterial coating for orthopedic implant surfaces

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