Loading, release and stability of epirubicin-loaded drug-eluting beads

Spindeldreier, Kirsten C; Thiesen, Judith; Krämer, Irene

doi:10.1177/1078155215594416

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Epirubicin concentration was analyzed according to a previously published protocol 18,19 . This was done through liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) as well as using a TSQ Quantum Ultra mass spectrometric detector (Thermo Fisher Scienti c) and a Dionex UltiMate 3000 RSLC Nano (Thermo Fisher Scienti c).…”

Section: Pharmacokinetics Studymentioning

confidence: 99%

Effects of Epirubicin-loaded HepaSphere Microsphere with a New Loading Method transarterial chemoembolization: In vitro and In vivo Experiments

Zhang,

Du,

Wang

et al. 2023

Preprint

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Objectives This study aimed to examine pharmacokinetic profiles and embolization effect of HepaSphere (HS) with a new loading method to reduce its expansion size.Methods HS microsphere were loaded in a solution of hypertonic saline and contrast medium at different ratio. Morphology, size distribution and drug loading capacity of the microsphere were evaluated to effectively reduce expansion of HS. Rabbits with hepatic VX2 tumors underwent conventional TACE, drug-eluting beads TACE with HS microsphere loading epirubicin by recommend method (dTACE) or by a new loading method (ndTACE). The plasma and tissue epirubicin concentration, tumor necrosis and the microsphere distribution within the tumor were assessed.Results It was found that the mean diameter of HS microspheres was effectively reduced to 102 ± 14 µm after loading with 10.0% NaCl and Ultravist (370 mg I /mL) at a ratio of 2: 8 ml. The loading capacity reached 78.7%. It was noted that the concentration of tumor epirubicin was significantly higher (p = 0.016) in the ndTACE group (11989.8 ± 5776.6 ng/g) than concentration in the dTACE (6516.5 ± 3682.3 ng/g) and in cTACE groups (1564.1 ± 696.1 ng/g, p < 0.001). Further, the tumor necrosis in group with the new loading method (ndTACE) was 92.4%.Conclusions The size of HS microsphere can be effectively reduced when it is loaded with a mixture of hypertonic saline and non-ionic contrast material. HS microsphere loaded with epirubicin using the new method (ndTACE) can increase the drug concentration in tumor and hence exert better improved antitumor effect.

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Section: Pharmacokinetics Studymentioning

confidence: 99%

Effects of Epirubicin-loaded HepaSphere Microsphere with a New Loading Method transarterial chemoembolization: In vitro and In vivo Experiments

Zhang,

Du,

Wang

et al. 2023

Preprint

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A Study on Overcoming Post‐TACE Drug Resistance in HCC Based on Controllable Oxygen Release‐Magnetic Hyperthermia Therapy

Huang,

Zhang,

et al. 2024

Adv Healthcare Materials

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Drug‐eluting bead transcatheter arterial chemoembolization (D‐TACE) is one of the first‐line treatment for intermediate hepatocellular carcinoma (HCC). However, the dual hypoxia microenvironment, due to inherent tumor hypoxia and TACE‐induced hypoxia, triggers drug resistance in HCC. To address this challenge, the study develops multicavitary microspheres capable of encapsulating oxygen and harnessing magnetic hyperthermia to enhance oxygen permeability. The novel multicavitary oxygen‐encapsulated magnetothermal drug‐eluting microspheres (OTD‐Ms) effectively reduce hypoxia‐related proteins (HIF‐1α, VEGF‐A) and drug resistance (P‐gp) both in vitro and in vivo. Moreover, these microspheres demonstrate improved TACE efficacy and enhance survival rates in a rabbit VX‐2 tumor model, suggesting their potential for HCC treatment.

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Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments

Zhang,

Du,

Wang

et al. 2023

Discov Onc

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Methods HS microspheres were loaded in a solution of hypertonic saline and contrast medium at different ratios. Morphology, size distribution, and drug loading capacity of the microsphere were evaluated. Rabbits with hepatic VX2 tumors underwent conventional TACE, drug-eluting beads TACE with HS microsphere loading epirubicin by recommended method (dTACE) or a new loading method (ndTACE). The plasma and tissue epirubicin concentration, tumor necrosis, and the microsphere distribution within the tumor were assessed. Results It was found that the mean diameter of HS microspheres was effectively reduced to 102 ± 14 μm after loading with 10.0% NaCl and Ultravist (370 mg I /mL) at a ratio of 2: 8 ml. The loading capacity reached 78.7%. It was noted that the concentration of tumor epirubicin was significantly higher (p = 0.016) in the ndTACE group (11,989.8 ± 5776.6 ng/g) than the concentration in the dTACE (6516.5 ± 3682.3 ng/g) and in cTACE groups (1564.1 ± 696.1 ng/g, p < 0.001). Further, the tumor necrosis in group with the new loading method (ndTACE) was 92.4%. Conclusions The size of HS microsphere can be effectively reduced when it is loaded with a mixture of hypertonic saline and non-ionic contrast material. HS microsphere loaded with epirubicin using the new method (ndTACE) can increase the drug concentration in tumor and hence exert better improved antitumor effect.

show abstract

Loading, release and stability of epirubicin-loaded drug-eluting beads

Cited by 6 publications

References 16 publications

Effects of Epirubicin-loaded HepaSphere Microsphere with a New Loading Method transarterial chemoembolization: In vitro and In vivo Experiments

Effects of Epirubicin-loaded HepaSphere Microsphere with a New Loading Method transarterial chemoembolization: In vitro and In vivo Experiments

A Study on Overcoming Post‐TACE Drug Resistance in HCC Based on Controllable Oxygen Release‐Magnetic Hyperthermia Therapy

Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments

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