Lobaric acid prevents the adverse effects of tetramethrin on the estrous cycle of female albino Wistar rats

Abstract

Tetramethrin (Tm) is a commonly used pesticide that has been reported to exert estrogen-antagonistic effects selectively on female rats. The present study was undertaken to assess the protective role of lobaric acid (La) on estrous cycle in Tm-treated female Wistar rats. Female rats were exposed to Tm (50 mg/kg b.w/day) only or in combination with La at low (50 mg/kg b.w/day) or high (100 mg/kg b.w/day) dose for 30 days. The results showed that Tm altered the estrous cycle of female rats by decreasing the levels of luteinizing hormone, follicular-stimulating hormone, progesterone, estrone, and estradiol while increasing testosterone level. The morphology of vaginal smears of Tm-treated female rats showed the presence of abnormal cells and/or structures at different phases of estrus cycle. Strikingly, in (Tm + La)-treated rats, all the observed adverse effects of Tm on the hormonal parameters, cell morphology, and the length of each phase of estrous cycle were significantly diminished in a dose-dependent manner. The docking results showed that La competes with Tm for Gonadotropin-Releasing Hormone (GnRH) receptor, thereby reducing the toxicity of Tm but did not cancel the response of GnRH receptor completely. In conclusion, our results designated that La could be used as a potential candidate in the management of insecticide-induced alterations of the reproductive cycle of rodents.

Fertility Evaluation of Adult Female Wistar Rats Administered with Ethanolic Extract of Pausinystalia yohimbe Stem Bark

“…3) of the rats in the groups treated with graded doses of the extract. Increased estrogen level promotes the storage of fat for healthy reproductive years which leads to weight gain [25]. The results obtained in this study agree with this assertion.…”

“…According to Amah-Tariah et al [27] "phytoestrogens are plant-derived natural compounds similar to estrogens in terms of structural and functional performance and therefore have estrogenic effects". "This estrogenic property either activates the estrogen receptors or increases estrogen synthesis by improving FSH concentrations" [25,28]. "Phytoestrogens have been reported to influence the hypothalamicpituitary-gonadal axis as well as the external genitalia" [27].…”

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities

“… Nguyen et al (2022b) proved that the treatment of female rats with lobaric acid ( 136 ) (50 and 100 mg/kg b.w./day) significantly ameliorated tetramethrin (50 mg/kg b.w/day)-induced alteration on estrous cycle. It reversed gonadotropins serum levels through influencing the pituitary/hypothalamic axis and competitively inhibited tetramethrin binding to GnRH receptor in both thermodynamic and kinetic processes.…”

Evaluating the Renal Status of Wood Sawmill Workers Exposed to wood Dust: a Cross-sectional Study

“…These preservatives protects the woods from decay and insect damage and have a high stability and water solubility which makes them persist in the environment. 14 The WSM apply preservatives on the wood by spraying or by hand brushing. Chronic kidney disease is a global public health menace.…”