Local allergic rhinitis - a big challenge in clinical practice

Stosović, R; Spirić, Vesna Tomić

doi:10.2298/sarh200724032s

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…The manufacturer of this product declares that treatment with OCL induced a decrease in the absolute count of eosinophils, neutrophils and monocytes, but all the values of these parameters remained within the laboratory reference range. et al 1993, Stosović and Bogić 1998, Ramirez et al 2018, Hashimoto et al 2023. Therefore, the OCL-induced a depletive effect on these cells, especially former ones, may be involved in shaping the anti-allergic properties of the drug.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, eosinophils are the essential effector of allergic inflammation. Several allergic dermatological diseases, including AD, are associated with both peripheral and/ or tissue eosinophilia (Stosović andBogić 1998, Ramirez et al 2018). Also, basophils play an important role in allergic responses and have been implicated, among others, as a source of histamine and pro-inflammatory eicosanoids in AD (James et al 1993); they play a significant role in the pathogenesis of itch in AD (Hashimoto et al 2023).…”

Section: Introductionmentioning

confidence: 99%

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Depletion of T and B cells in lymphoid tissues of mice induced by oclacitinib, a Janus kinase inhibitor

Jasiecka-Mikołajczyk,

Maślanka

2023

Polish Journal of Veterinary Sciences

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The main purpose of the study was to determine the safety of oclacitinib (OCL), a Janus kinase inhibitor, with respect of its effect on CD4 + and CD8 + T cells as well as B cells in the lymphoid tissue. The mice were treated orally with OCL at a dose of 2.7 mg/kg for 14 days and peripheral blood, head and neck lymph nodes (HNLNs), mediastinal lymph nodes (MLNs) and spleen were collected. The study found that OCL induced depletion of CD4 + T cells in the HNLNs and MLNs, while it did not affect the absolute count of CD8 + T cells in these tissues. Also OCL caused a loss of B cells in the HNLNs, although not in the MLNs. Moreover, OCL depleted B cells in the peripheral blood, but did not affect the absolute count of CD4 + and CD8 + T cells. Thus, it can be concluded that OCL may induce a depletive effect on CD4 + and CD8 + T cells as well as B cells in the lymphoid tissue. This effect should be seen as an unfavorable one, especially in patients with infections. Therefore, a clinical implication is that in such patients, the benefit/risk ratio should be thoroughly considered by clinicians. Moreover, OCL reduced the absolute count of eosinophils, basophils, neutrophils and monocytes. However, it is uncertain whether this effect should be considered to be of clinical importance because the levels of these cells were within the physiological range. It is possible that the depletive effect of OCL toward T and B cells, as well as eosinophils and basophils may contribute to the beneficial effects of the drug in the treatment of skin allergic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depletion of T and B cells in lymphoid tissues of mice induced by oclacitinib, a Janus kinase inhibitor

Jasiecka-Mikołajczyk,

Maślanka

2023

Polish Journal of Veterinary Sciences

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Radiological Assessment of Centrally Limited Sinus Disease in Allergic and Non-Atopic Chronic Rhinosinusitis

Mohd Kutubudin,

Hamizan,

Yean

et al. 2024

Sinusitis

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Background: A centrally limited radiological pattern, marked by mucosal thickening in the central sinonasal cavity with relatively unaffected surrounding sinuses, has been linked to allergy in chronic rhinosinusitis (CRS). However, a comparison between allergic and non-atopic CRS patients is lacking. The role of anatomical variations in the ostiomeatal complex also remains unclear. Methods: Adult CRS patients with allergic rhinitis, asthma, eczema, and positive allergy tests were recruited. CRS patients without atopic disease and negative allergy tests were controls. CT scans were evaluated for the centrally limited radiologic pattern. Anatomical variations in the ostiomeatal complex were also examined. Results: The study included 15 allergic CRS and 17 non-atopic CRS participants. Allergic CRS patients showed a higher prevalence of centrally limited sinus disease compared to non-atopic CRS patients (50% vs. 14.7%, p < 0.01). No anatomical variations were conclusively linked to allergy status or the centrally limited sinus disease. Conclusion: Centrally limited sinus disease on radiology is associated with underlying allergy in CRS but should not be the primary diagnostic tool. Anatomical variants did not clearly relate to allergy status or the radiologic pattern but this requires further studies.

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Local allergic rhinitis - a big challenge in clinical practice

Cited by 2 publications

References 40 publications

Depletion of T and B cells in lymphoid tissues of mice induced by oclacitinib, a Janus kinase inhibitor

Depletion of T and B cells in lymphoid tissues of mice induced by oclacitinib, a Janus kinase inhibitor

Radiological Assessment of Centrally Limited Sinus Disease in Allergic and Non-Atopic Chronic Rhinosinusitis

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