Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen

Rondón, Carmen; Blanca‐López, Natalia; Aranda, Ana; Herrera, Ricardo Jorge Hernández; Rodriguez-Bada, J.L.; Cantó, Gabriela; Mayorga, Cristobalina; Torres, Marı́a José; Campo, Paloma; Blanca, Miguel

doi:10.1016/j.jaci.2010.12.013

Cited by 65 publications

(90 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to our findings, Rondón et al [15] reported that the patients with a positive NPT had persistent moderate/severe symptoms. In addition, we found no difference between the positive and negative NPT groups for symptoms in terms of seasonal or perennial rhinitis.…”

Section: Discussionsupporting

confidence: 92%

The Relevance of Nasal Provocation Testing in Children with Nonallergic Rhinitis

Duman

Bostancı

Özmen

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: It is important to understand that allergic rhinitis, whether seasonal or perennial, may be difficult to distinguish clinically from the nonallergic forms of rhinitis. Objective: This study aimed to investigate the presence of local allergic rhinitis (LAR) in children who have allergic rhinitis symptoms in the absence of skin test positivity and specific IgE by performing a nasal provocation test (NPT). Methods: Our study followed a case-controlled, prospective design. Twenty-eight patients and 30 healthy children were included in the study in a pollen-free season. The NPTs with a grass mix, Dermatophagoides pteronyssinus (DP) and D. farinae (DF) allergens were performed with an interval of 1 week. The total symptom score and visual analog scale, nasal eosinophilia and pulmonary function tests were evaluated before and after each NPT. The change to nasal flow and resistance was recorded by anterior rhinomanometry. Results: The symptom frequencies before the NPTs were as follows: nasal congestion 100%; itching 82.1%; rhinorrhea 75% and sneezing 71.4%. The NPT was positive in 7 (25%) patients. In the NPT-positive group there was a statistically significant decrease in nasal flow at the concentrations of 10 and 100 IR/ml for DF (p = 0.026, p = 0.031, respectively). In the NPT-positive group total nasal resistance for DP was increased at the concentrations of 0.1 and 10 IR/ml, and for DF at 10 and 100 IR/ml (p = 0.049, p = 0.041, p = 0.022, p = 0.035, respectively). Conclusions: We emphasize that the diagnosis of LAR should be taken into consideration by pediatricians and pediatric allergy specialists.

show abstract

Section: Discussionsupporting

confidence: 92%

The Relevance of Nasal Provocation Testing in Children with Nonallergic Rhinitis

Duman

Bostancı

Özmen

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…However, even in view of these potential limitations, a 21% of rate of conversion to SAR in patients who have had LAR for more than 7 years is an important figure. These findings together with the excellent results obtained in LAR patients treated with specific immunotherapy [10] reinforce the need for an early and correct diagnosis of LAR in nonatopic rhinitis patients.…”

supporting

confidence: 64%

More Research Is Needed for Local Allergic Rhinitis

Rondón

Campo

Blanca‐López

et al. 2015

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

“…Preliminary studies of immunotherapy suggest that patients with local allergic reactions benefit from this treatment [24,25,26]. …”

Section: Discussionmentioning

confidence: 99%

Local Allergic Nasal Reactions Convert to Classic Systemic Allergic Reactions: A Long-Term Follow-Up

Sennekamp¹,

Joest²,

Filipiak-Pittroff³

et al. 2015

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: There is poor knowledge about the evolution of the negative skin test in local allergy over time. Does the negative skin test of patients with local allergies remain negative permanently or does it become positive? Methods: We describe our long-term observation concerning the evolution of the negative skin test over time. This is a retrospective, follow-up study using data from the medical records of a group of patients with local allergy. A total of 42 patients aged between 3 and 70 years (median age: 31.5 years) were studied. The duration of follow-up varied from 1 to 27 years. Skin tests were performed using the skin-prick test and intracutaneous techniques for pollen, molds, mites, feathers (goose and duck) and animal danders. Nasal provocation tests were conducted with the same allergens. Additionally, specific IgE in 17 patients was measured by enzyme allergosorbent test. Results: During the period of observation, the negative skin test reactions converted into positive reactions in 17 patients (40%). In addition to the negative skin reactions, 55% of the patients also presented positive skin reactions. The conversion rate was higher in children and adolescents than in adults. In 4 patients, conversions occurred >7 years after the initial examination. Specific IgE was negative in all but 2 patients, in whom the conversion in the skin test was accompanied by a switch from negative to positive specific IgE. Conclusion: Conversions from local to classic systemic respiratory allergic reactions appear to be a common phenomenon.

show abstract

Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen

Cited by 65 publications

References 17 publications

The Relevance of Nasal Provocation Testing in Children with Nonallergic Rhinitis

The Relevance of Nasal Provocation Testing in Children with Nonallergic Rhinitis

More Research Is Needed for Local Allergic Rhinitis

Local Allergic Nasal Reactions Convert to Classic Systemic Allergic Reactions: A Long-Term Follow-Up

Contact Info

Product

Resources

About