Local and Global Fiber Tractography in Patients with Epilepsy

Anastasopoulos, Constantin; Reisert, Marco; Kiselev, Valerij G.; Thanh, Thao Nguyen; Schulze‐Bonhage, Andreas; Zentner, Josef; Mader, Irina

doi:10.3174/ajnr.a3752

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…For in vivo DTI a b-value of 1000 s/mm2 and 30 diffusion directions is in the optimal range. Although fiber tracking approaches generally benefit from higher b-values und more diffusion directions, higher b-values would have led to low SNR and several studies have validated the results of the applied tractography method using similar acquisition schemes (Harsan et al, 2013; Anastasopoulos et al, 2014; Horn et al, 2014). …”

Section: Methodsmentioning

confidence: 99%

Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

Janz

Schwaderlapp

Heining

et al. 2017

eLife

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Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy. It is unknown whether pathological processes preceding epilepsy onset are indicators of later disease severity. Using longitudinal multi-modal MRI, we monitored hippocampal injury and tissue reorganization during epileptogenesis in a mouse mTLE model. The prognostic value of MRI biomarkers was assessed by retrospective correlations with pathological hallmarks Here, we show for the first time that the extent of early hippocampal neurodegeneration and progressive microstructural changes in the dentate gyrus translate to the severity of hippocampal sclerosis and seizure burden in chronic epilepsy. Moreover, we demonstrate that structural MRI biomarkers reflect the extent of sclerosis in human hippocampi. Our findings may allow an early prognosis of disease severity in mTLE before its first clinical manifestations, thus expanding the therapeutic window.DOI: http://dx.doi.org/10.7554/eLife.25742.001

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Section: Methodsmentioning

confidence: 99%

Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

Janz

Schwaderlapp

Heining

et al. 2017

eLife

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“…Usually results of WMT of language circuits are challenging to interpret, particularly through perilesional disruptions; however, in epilepsy patients, white matter displays few abnormalities, allowing more reliable results (Anastasopoulos et al, 2014, Carlson et al, 2014). Accordingly, some evidence already suggests a functional language outcome benefit from performing tractography as part of the pre-surgical planning for epilepsy surgery (Jeong et al, 2015, Szmuda et al, 2016).…”

Section: Supratentorial Lesionsmentioning

confidence: 99%

White matter tractography for neurosurgical planning: A topography-based review of the current state of the art

Essayed

Zhang

Unadkat

et al. 2017

NeuroImage: Clinical

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We perform a review of the literature in the field of white matter tractography for neurosurgical planning, focusing on those works where tractography was correlated with clinical information such as patient outcome, clinical functional testing, or electro-cortical stimulation. We organize the review by anatomical location in the brain and by surgical procedure, including both supratentorial and infratentorial pathologies, and excluding spinal cord applications. Where possible, we discuss implications of tractography for clinical care, as well as clinically relevant technical considerations regarding the tractography methods.We find that tractography is a valuable tool in variable situations in modern neurosurgery. Our survey of recent reports demonstrates multiple potentially successful applications of white matter tractography in neurosurgery, with progress towards overcoming clinical challenges of standardization and interpretation.

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“…Tractography can also be used to study white matter insults in relation to epilepsy (for a review, see Anastasopoulos et al, 2014;Ciccarelli et al, 2008;Winston, 2015). Studies generally report a FA decrease and a mean diffusivity increase in pathways near the epileptogenic temporal lobe (eg, optic radiations, uncinate and arcuate fasciculi, cingulum, fornix, and external capsule), which reflects reduced axonal density in TLE.…”

Section: Structural Connectivitymentioning

confidence: 99%