Local and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping

Erling, Nilon; Montero, Edna Frasson de Souza; Sannomiya, Paulina; Poli-de-Figueiredo, Luiz Francisco

doi:10.6061/clinics/2013(12)12

Cited by 28 publications

(18 citation statements)

References 40 publications

(41 reference statements)

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“…) and gut ischaemia (Erling et al . ), and in sepsis‐induced organ damage (Olguner et al . ) and it has been suggested that this technique might be used for additional non‐ischaemic bowl disorders.…”

Section: Hypoxia‐inducible Factors (Hifs)mentioning

confidence: 99%

“…Additional animal studies indicate that RIP might be useful in other medical fields. Animal studies showed that RIP may also be organ protective in hepatic (Tapuria et al 2012) and gut ischaemia (Erling et al 2013), and in sepsis-induced organ damage (Olguner et al 2013) and it has been suggested that this technique might be used for additional non-ischaemic bowl disorders. The use of RIP in trauma may also improve the outcome of casualties, enhancing pre-hospital and overall survival.…”

Section: Additional Potential Clinical Uses For Ripmentioning

confidence: 99%

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Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

et al. 2015

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Transient ischaemia leads to tolerance to subsequent protracted ischaemia. This 'ischaemia pre-conditioning' results from the induction of numerous protective genes, involved in cell metabolism, proliferation and survival, in antioxidant capacity, angiogenesis, vascular tone and erythropoiesis. Hypoxia-inducible factors (HIF) play a pivotal role in this transcriptional adaptive response. HIF prolyl hydroxylases (PHDs), serving as oxygen sensors, control HIFα degradation. HIF-mediated ischaemic pre-conditioning can be achieved with the administration of PHD inhibitors, with the attenuation of organ injury under various hypoxic and toxic insults. Clinical trials are currently under way, evaluating PHD inhibitors as inducers of erythropoietin. Once their safety is established, their potential use might be further tested in clinical trials in various forms of acute ischaemic and toxic organ damage. Repeated transient limb ischaemia was also found to attenuate ischaemic injury in remote organs. This 'remote ischaemic pre-conditioning' phenomenon (RIP) has been extensively studied recently in small clinical trials, preceding, or in parallel with an abrupt insult, such as myocardial infarction, cardiac surgery or radiocontrast administration. Initial results are promising, suggesting organ protection. Large-scale multi-centre studies are currently under way, evaluating the protective potential of RIP in cardiac surgery, in the management of myocardial infarction and in organ transplantation. The mechanisms of organ protection provided by RIP are poorly understood, but HIF seemingly play a role as well. Thus, Inhibition of HIF degradation with PHD inhibitors, as well as RIP (in part through HIF), might develop into novel clinical interventions in organ protection in the near future.

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Section: Hypoxia‐inducible Factors (Hifs)mentioning

confidence: 99%

Section: Additional Potential Clinical Uses For Ripmentioning

confidence: 99%

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

et al. 2015

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“…1,2 Mesenteric ischemia may occur owing to a restriction of intra-abdominal blood supply as a result of physiological conditions (e.g. exercise, stress) or in pathophysiological events such as strangulation, adhesions, thrombosis, embolies, trauma, shock, complications to surgery or organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion

et al. 2015

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Intestinal ischemia is a serious condition that may lead to both local and systemic inflammatory responses. Restoration of blood supply (reperfusion) to ischemic tissues often increases the extent of the tissue injury. Cysteine-rich angiogenic inducer 61 (Cyr61)/CCN1 is an extracellular matrix-associated signaling protein that has diverse functions. CCN1 is highly expressed at sites of inﬂammation and wound repair, and may modify cell responses. This study aimed to investigate regulation and cellular distribution of CCN1 in intestinal ischemia/reperfusion (I/R) injury in pigs. After intestinal I/R, increased expression of CCN1 was detected by quantitative RT-PCR, Western blot analysis and immunohistochemistry compared with non-ischemic intestine. Immunoflorescence staining revealed that CCN1 was mainly up-regulated in intestinal mucosa after intestinal I/R. Microvillus epithelial cells and vascular endothelial cells were strongly positive for CCN1 in intestinal I/R, while natural killer cells and/or subsets of neutrophils were only modestly positive for CCN1. Furthermore, blood samples taken from the portal and caval veins during ischemia and after reperfusion showed no change of the CCN1 levels, indicating that CCN1 was locally regulated. In conclusion, these observations show, for the first time, that the CCN1 molecule is up-regulated in response to intestinal I/R in a local manner.

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“…However, the comparison between two independent groups, ALO-ALO and Fk-Fk-IPC, significance was observed (p = 0.035) to the beneficial effect of IPC-R in terms of development score. The role of IPC in reducing ischemic injury has been widely documented in a range of tissues, including IR injury of the small intestine [11][12][13][14][15][16] . A recent study shows that Ischemic preconditioning increased the intestinal stem cell activities in the intestinal crypts in mice 17 .…”

Section: Resultsmentioning

confidence: 99%

Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice

et al. 2016

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PURPOSE:To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS:Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals were distributed with and without IPC-R. It was obtained the following subgroups: Tx, IPC-R, Fk, IPC-Fk, in both strains. Intestinal grafts were stained with hematoxylin and eosin and immunohistochemically. RESULTS:The graft development evaluation in ISO group showed that IPC-R reduced the development compared with ISO-Tx and Fk: 9.0±0.6). The graft rejection was lower in groups treated with IPC-R (-18%), Fk (-68%) or both (-61%) compared with ALO-Tx. CONCLUSION:Remote ischemic preconditioning showed benefic effect even associate with Tacrolimus on the development and acute rejection of the fetal small bowel graft in the Isogenic and Allogenic transplants.

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Local and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping

Cited by 28 publications

References 40 publications

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion

Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice

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