Local and systemic chemokine patterns in a human musculoskeletal trauma model

Daniel, Bastian; Tamburstuen, Margareth V.; Lyngstadaas, Ståle Petter; Reikerås, Olav

doi:10.1007/s00011-009-0013-y

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…In agreement with previous studies, a marked increase in IL-6 and IL-10 was seen day 1 following surgery. Moreover, IP-10 levels decreased significantly the day after surgery, in agreement with a previous study of THA 15,18,45 . This could result from IL-10mediated inhibition of IP-10 as previously reported, or IP-10 peaking early to recruit T cells to damaged tissue followed by a marked decrease, as seen for T cells 16,46,47 .…”

Section: D6mwtsupporting

confidence: 92%

Inflammation and post-operative recovery in patients undergoing total knee arthroplasty-secondary analysis of a randomized controlled trial

Langkilde

Jakobsen

Bandholm

et al. 2017

Osteoarthritis and Cartilage

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Section: D6mwtsupporting

confidence: 92%

Inflammation and post-operative recovery in patients undergoing total knee arthroplasty-secondary analysis of a randomized controlled trial

Langkilde

Jakobsen

Bandholm

et al. 2017

Osteoarthritis and Cartilage

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“…5). Bastian et al clearly showed a significant acute post-traumatic rise in monocyte and neutrophil levels as well as total WBC count amongst subjects who had total hip replacement arthroplasty [24]. This work confirmed that chemokine burst arising from tissue damage was responsible for the observed neutrophilia and monocytaemia.…”

Section: Physiologic and Clinical Implicationsmentioning

confidence: 56%

Leucocyte Profile of Adult Nigerians as Indicator of Severity Level of Acute Musculoskeletal Trauma

Asemota

Ekene

Ehebha

et al. 2019

IBRR

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Leucocytosis, marked increase in the number of white blood cells (WBC) is a known physiological response to trauma. In recent times, several studies have asserted the absence of this response in Africans. In view of this, current study investigated the existence of, and prognostic implications of post-traumatic leucocytosis amongst adult Nigerians with acute musculoskeletal (MSK) trauma. Two hundred and twenty three (223) adult male and females (MSK traumatized) and fifty apparently healthy volunteers (adults) were ethically recruited from the National Orthopaedic Hospital, Enugu, regional centre for trauma, orthopaedic, burns and plastic surgery in south-east Nigeria. Using the Leishman’s stained blood smear technique, leucocyte profiles [Neutrophil, Lymphocytes, Basophils, Eosinophils and Monocyte counts] were obtained for each participant. In all case, Age, Gender and duration of hospitalization were also obtained. Following careful analysis, study found, using one way analysis of variance (ANOVA), a statistically significant increase (p < .05) in acutely traumatized subjects; with adults of ages 20 to 49 years constituting the majority (70%). A statistically significant lymphopenia was also observed in test population, with Pearson Product Moment Correlation proving positive for higher levels of WBC counts. A negative correlation was also seen for Neutrophils and lymphocyte counts, implicating the Neutrophil-Lymphocyte Stress Factor (NLSF). We recommend the exploration of the NLSF for prognosis of Leucocytosis in Africans.

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“…70 We observed several other patterns consistent with previous literature. These include MIF (upregulated 71 ), TRAIL (upregulated and previously reported to be increased in elderly osteoporotic fractures 72 ), and Eotaxin (downregulated, and previously reported to be downregulated in musculoskeletal surgical trauma 67,73 ).…”

Section: Data and Code Availabilitymentioning

confidence: 98%

Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panel

Fathi,

Karkanitsa,

Rupert

et al. 2024

Preprint

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Severe trauma can induce systemic inflammation but also immunosuppression, which makes understanding the immune response of trauma patients critical for therapeutic development and treatment approaches. By evaluating plasma of 50 healthy volunteers and 1000 trauma patients across five trauma centers in the United States, we identified 6 novel changes in immune proteins after traumatic injury and further new variations by sex, age, trauma type, comorbidities, as well as a new biomarker predictor of patient survival. Blood was collected at the time of arrival at Level 1 trauma centers and patients were stratified based on trauma level, tissues injured, and injury types. Trauma patients had significantly upregulated proteins associated with immune activation (IL-23, MIP-5), immunosuppression (IL-10) and pleiotropic cytokines (IL-29, IL-6). A high ratio of IL-29 to IL-10 was identified as a new predictor of survival with ROC area of 0.933. Using machine learning, we identified three increased proteins (MIF, TRAIL, IL-29) and three decreased proteins (IL-7, TPO, IL-8) that were the most important in distinguishing a trauma blood profile from those of healthy controls. Biologic sex altered phenotype with IL-8 and MIF being lower in healthy women, but higher in female trauma patients when compared to male counterparts. This work identifies new responses to injury that may influence systemic immune dysfunction, serving as targets for therapeutics and immediate clinical benefit in identifying at-risk patients.

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Local and systemic chemokine patterns in a human musculoskeletal trauma model

Cited by 7 publications

References 45 publications

Inflammation and post-operative recovery in patients undergoing total knee arthroplasty-secondary analysis of a randomized controlled trial

Inflammation and post-operative recovery in patients undergoing total knee arthroplasty-secondary analysis of a randomized controlled trial

Leucocyte Profile of Adult Nigerians as Indicator of Severity Level of Acute Musculoskeletal Trauma

Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panel

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