Local and Systemic Immune Responses to Food Antigens in Neonates and Infants

Rieger, C.; Renz, H; Vestner, R.; Brehler, C.; Horn, Andreas

doi:10.2500/108854191778879197

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…If anything, supplementation with L. acidophilus LAVRI-A1 was associated with lower IgA production, although this was not statistically significant. Consistent with other reports [8,27], this study also demonstrated that the development of allergic sensitization was associated with higher total IgA levels, as noted in the placebo group (P = 0.021) at 6 months of age. The reasons for this are unclear, but it is of note that a key environmental 'risk factor' for allergic disease, namely early introduction of solid food, was also associated with increased IgA levels.…”

Section: Discussionsupporting

confidence: 93%

Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development

Martino

Currie

Taylor

et al. 2007

Clin Experimental Allergy

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Section: Discussionsupporting

confidence: 93%

Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development

Martino

Currie

Taylor

et al. 2007

Clin Experimental Allergy

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“…The gastrointestinal absorption of antigenically intact dietary proteins is more extensive during the first days of life, and antibodies to milk proteins can be detected in the serum of neonates [22]. Sensitive methods allow even the detection of antidietary antibodies at low titre in normal subjects [23].…”

Section: Measurement Of Iga and Igg Activity To Non-dietary Antigensmentioning

confidence: 99%

Early impairment of gut mucosal immunity in HIV-1-infected children

Quesnel¹,

Moja²,

Blanche

et al. 1994

Clinical and Experimental Immunology

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SUMMARYThis study was performed in 27 HIV-1 + children to characterize the IgA hyperglobulinaemia observed in the serum during the course of HIV-1 infection. By contrast with serum IgG, which increased very early, IgA elevation was related to the decrease of CD4+ cell percentage. It was demonstrated that IgAl subclass increased selectively. Secretory IgA (SIgA) and IgA and IgG activity to gliadin, bovine serum albumin (BSA) and at a lower level to casein could be detected in the serum at the early stages of HIV infection, but SIgA levels and IgA activity to gliadin further increased during the course of immunodeficiency. By contrast, IgA and IgG activity to tetanus toxoid did not change. These data demonstrate that the hyper IgA, closely related to the degree of immunodeficiency, could be due in part to a disturbance of the gut mucosal immune system. Moreover, impaired intestinal immunity seems to appear very early, and to progress during the course of paediatric HIV-1 infection.

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“…The present paper is a follow-up study of a previously published investigation on secretory. immunity against cow's milk protein in neonates at risk of allergy (4, 5).…”

mentioning

confidence: 99%

Breast Feeding Modifies Production of SlgA Cow's Milk‐Antibodies in Infants

et al. 1991

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One hundred and fifty-eight healthy mature newborns were divided into 3 groups according to their risk of allergy: Group A, no risk (n = 62), group B, low risk (n = 30) and Group C, high risk (n = 66). Saliva was collected at birth and after 3 and 6 months. SIgA anti-casein and anti-beta-lactoglobulin were determined by a direct ELISA technique. The highest concentrations of secretory antibodies were measured after birth. After 3 months, breast fed infants had lower salivary SIgA anti-casein concentrations than the group receiving cow's milk (p less than 0.01). The effect of breast-feeding was seen even after a nursing period of only 3 weeks. Infants without risk of allergy fed cow's milk exclusively had higher SIgA anti-casein (p less than 0.03) and anti-beta-lactoglobulin concentrations than low risk infants at the age of 6 months. These data show a modifying effect of breast feeding on salivary SIgA production against cow's milk protein.

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Local and Systemic Immune Responses to Food Antigens in Neonates and Infants

Cited by 3 publications

References 5 publications

Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development

Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development

Early impairment of gut mucosal immunity in HIV-1-infected children

Breast Feeding Modifies Production of SlgA Cow's Milk‐Antibodies in Infants

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