Local antibacterial depot systems in the treatment of bone and joint infection

Abstract

Local depot systems saturated with antibiotics are an integral part of the complex treatment of osteoarticular infections, since they can effectively combat microbial biofilms by creating a concentration of drugs many times higher than necessary for planktonic forms of microorganisms. Currently, there are many carrier matrices with different properties. Only a small part of them have been sufficiently well studied and are actively used in clinical practice, such as bone cement based on polymethyl methacrylate, calcium sulfate, collagen, allografts, etc. The vast majority of local systems have been studied only in vitro and in vivo conditions. This review is devoted to a description of the currently existing depot systems, their main properties, advantages and disadvantages, as well as possible prospects for the further use of a particular matrix both in treatment and for preventive purposes.