Local Dosimetry and Qualitative Changes in 226Ra- and 90Sr-90Y-labeled Beagle Humeri

Momeni, M.H.; Williams, R.J.R.; Fisher, Gerald L.; Rosenblatt, L.S.

doi:10.1097/00004032-197601000-00002

Cited by 7 publications

(4 citation statements)

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“…The average radiation dose to pig mented tissues was estimated at 150 and 460 rad, integrated to 5 years after intravenous injections for 28.1 and 83.6,wCi 226Ra, respectively. The principal cause of death in these beagles, injected with 226Ra for study of radium metabolism, toxicity, and later somatic effects, was from osteosarcoma and skeletal fractures [6,7]. Pigmentary changes involving the retinal and choroidal melanotic tissues of the nontapetal fundus were observed, but were not quantitated because of considerable variability in ophthalmoscopic appearance of these tissues in control beagles.…”

Section: Discussionmentioning

confidence: 99%

“…The details of the experimental design for long-term toxicity and metabolism of 226Ra in beagles for extrapolation to man have been published [6,7], Table I summarizes the number of dogs injected with 226Ra, the activity levels, and survival ages.…”

Section: Methodsmentioning

confidence: 99%

“…In order to compare the concentrations of radium in the pigmented tissues obtained from different dogs, each radium concentration was expressed as a percentage of the total content of radium in the beagle measured 35 days after the radium injections, at which time most of the radium in plasma and soft tissues had been excreted or incorporated into the skeleton [6], The uveal concentration of 226Ra, extrapolated to the time of last injection, was only 5x 1 (h3% of total body radium ( fig. 1).…”

Section: Dosimetrymentioning

confidence: 99%

“…Even though injected 226Ra is retained principally in the skeleton, a significant quantity is localized in the canine ocular melanotic tissues [2,4,5,10], Ophthalmic examination of beagles after intravenous injections of 226Ra chloride has revealed pigmentary changes in the melanotic tissues of the uvea (depigmentation or hyperpigmentation) and progressive destruc tion of the tapetum lucidum [2,[4][5][6][7][8][9][10]. The concentration of 226Ra in canine eyes was significantly elevated above the plasma concentration and was specifically localized in the uveal pigmented cells and tapetal iridiocytes [3,5,8,10].…”

Section: Introductionmentioning

confidence: 99%

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Progression of <sup>226</sup>Ra-Induced Ocular Alterations in Beagles (with 1 color plate)

Momeni¹,

Muggli²

1977

Ophthalmic Res

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The temporal progression of ocular injury involving the iris and tapetum lucidum in beagles injected with ²²⁶Ra was quantitated by assigning subjective numerical indices. Concentration of radium in melanotic ocular tissue was measured by an auto-radiographic technique. The observed changes consisted of iris hyperpigmentation, de-pigmentation and progressive tapetal loss. Each change was dependent on the injected radium activity and on the time after injection. At higher radium levels iris depigmentation progressed centrally and peripherally, exposing fibrillar structural elements. Tapetal alteration progressed initially from a granular or finely stippled pattern to pigmented foci interspersed between hyporeflective tapetum and finally to a complete loss of tapetum and exposure of the choroidal vasculature. The average radiation dose from injections of 28.1 and 83.6 μCi ²²⁶Ra to ocular pigmented tissues integrated for 5 years was estimated at 150 and 460 rad, respectively. An injection of 0.18 μCi ²²⁶Ra did not induce an ocular alteration within 10 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Dosimetrymentioning

confidence: 99%