Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

Huo, Wei; Gao, Xing‐Hua; Sun, Xiu-Ping; Qi, Ruiqun; Hong, Yuxiao; Mchepange, Uwesu Omari; Li, Xiaodong; Xiao, Bokui; Lin, Junping; Jiang, Yi; Zhang, Li; Li, Yuanhong; Xiao, Ting; Chen, John Z S; Chen, Hong‐Duo

doi:10.1086/651506

Cited by 58 publications

(53 citation statements)

References 13 publications

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“…Similar to our study, in some patients warts turned more keratotic, known as "bulging up," before clearance (Huo et al, 2010). The clearance rate during the 3 month follow up period was 53.57% in the thermotherapy group while only 11.54% of patients in the placebo group healed.…”

Section: Discussionsupporting

confidence: 87%

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial

Firouzabadi

Khamesipour

Ghandi

et al. 2017

Dermatologic Therapy

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The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 skin warts. The participants were randomly assigned into two groups to receive cryotherapy (every 2 to 3 weeks up to six sessions if required) or thermotherapy (one session). The patients in both groups were followed every 2 to 3 weeks for the first three months, and then three months after the last treatment session. The clearance rate was 79.2% in the thermotherapy group and 58.3% in the cryotherapy group with no significant difference (p = 0.212). The rate of scarring in the thermotherapy group was 20% (p = .018). A higher clearance rate was achieved in the thermotherapy group. However, this result was not statistically significant. There were some minimal post-treatment complications. Patients needed only one session of thermotherapy. Due to the risk of scarring, we suggest thermotherapy only as a suitable treatment method for palmoplantar warts.

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Section: Discussionsupporting

confidence: 87%

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial

Firouzabadi

Khamesipour

Ghandi

et al. 2017

Dermatologic Therapy

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“…Combination treatments can be undertaken 10,17,20,21 Other treatments: dithranol, 87 5-FU, 93 formaldehyde, 78 glutaraldehyde, 35 hyperthermia, 55 laser, 58,65 PDT, 68,73 podophyllotoxin, 90 topical immunotherapy 133,136 Plane warts On the backs of the hands or face, plane warts are mainly a cosmetic problem and spontaneous clearance can often be awaited. Destructive and caustic agents are more likely to produce scarring at these sites and should be used with care Salicylic acid cream/ointment 2-10% or cautious use of salicylic acid paint, 12-17%, used without occlusion Cryotherapy, milder freeze Topical retinoid 110,111 Others treatments: acupuncture, 171 cantharidin, 41 for the most part, weak.…”

Section: Future Directionsmentioning

confidence: 99%

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

et al. 2014

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“…Temperature-controlled systems using the combination of a hyperthermic apparatus and a noninvasive temperature monitor have been developed, and some of them have been used clinically [3,7,8,10,[14][15][16]. A noncontact type thermal monitoring system, other than thermography, has also been reported [3,10,14]; however, it only shows one value for the average temperature in a certain area.…”

Section: Discussionmentioning

confidence: 99%

“…A noncontact type thermal monitoring system, other than thermography, has also been reported [3,10,14]; however, it only shows one value for the average temperature in a certain area. In contrast, the present thermal sensor circuit is unique in its ability to acquire multipoint temperatures (thermal images) using thermograph.…”

Section: Discussionmentioning

confidence: 99%

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Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia

et al. 2017

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Laser hyperthermia is a powerful therapeutic modality that suppresses the growth of proliferative lesions. In hyperthermia, the optimal temperature range is dependent on the disease; thus, a temperature-driven laser output control system is desirable. Such a laser output control system, integrated with a thermal sensor circuit based on thermography, has been established. In this study, the feasibility of the developed system was examined by irradiating mouse skin. The system is composed of a thermograph, a thermal sensor circuit (PC and microcontroller), and an infrared laser. Based on the maximum temperature in the laser-irradiated area acquired every 100 ms during irradiation, the laser power was controlled such that the maximum temperature was maintained at a preset value. Temperature-controlled laser hyperthermia using the thermal sensor circuit was shown to suppress temperature fluctuations during irradiation (SD ∼ 0.14 ∘ C) to less than 1/10 of those seen without the thermal sensor circuit (SD ∼ 1.6 ∘ C). The thermal sensor circuit was able to satisfactorily stabilize the temperature at the preset value. This system can therefore provide noncontact laser hyperthermia with the ability to maintain a constant temperature in the irradiated area.

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Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

Cited by 58 publications

References 13 publications

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia

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