PurposeThis study aims to investigate the multiple influence paths or underlying mechanisms of entrepreneurial leadership (EL) on adaptive innovation from the perspectives of organizational learning and resource management, drawing on complex adaptive system theory.Design/methodology/approachWith a questionnaire survey of 317 senior and middle managers from different firms in China, structural equation modeling was used to test the hypothesized conceptual model, and bootstrapping method was employed to examine the multiple mediating effects.FindingsResults indicate that EL has a significant and positive effect on adaptive innovation. This relationship is partially mediated through exploitative learning, exploratory learning, resource bricolage and boundary-spanning integration, respectively. The impact of EL on adaptive innovation is also sequentially transmitted through exploitative learning and resource bricolage or exploratory learning and boundary-spanning integration.Originality/valueAdaptive innovation has become a firm competition strategy to cope with dynamic changes in current uncertain environment where EL can play its effectiveness to engage firms in such innovation activities. However, the question of why and how EL drives adaptive innovation has yet to be discussed. This study highlights the innovation effectiveness of EL and the triggering process of adaptive innovation, and contributes to several countermeasures for firms to implement leadership and innovation practices responding to uncertain environment.