Local metabolic, pathophysiological and histological changes in venous ulcers

Maksimović, Ž; Maksimović, M.

doi:10.1258/026835507780807211

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…7,14 The blood flow bypasses the capillaries, which leads to an impaired transcapillary metabolism, microcirculatory dysfunction, and the subsequent development of trophic ulcers. 25 The results of this study showed that there was no statistically significant difference between C4 and C5/C6 CEAP classes in terms of superficial and perforator venous reflux parameters. This study would suggest that none of the developmental theories of trophic ulcers find their full hemodynamic confirmation.…”

Section: Discussionmentioning

confidence: 59%

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Varicose Veins: A Local or Systemic Hemodynamic Disorder?

Каlinin

Suchkov

Laut³

et al. 2020

Journal of Diagnostic Medical Sonography

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Objective: To determine the capabilities of a sonographic examination to evaluate local and systemic hemodynamic disorders in patients with varicose disease. Materials and Methods: This study included 583 patients with varicose veins, among whom 348 had trophic disorders. All subjects underwent lower limb duplex sonography and superficial, perforator, and deep venous diameter measurements, as well as had a calculated velocity for antegrade and reflux flow. Peripheral resistive index (RI) in the arteries, accompanying perforator veins (PVs), was analyzed. In addition, echocardiography was performed on 46 of the participants. Results: A statistically significant difference in the diameter of the great saphenous vein was obtained between class C2 and C4 varicose veins ( P < .05). Similar findings were obtained for the diameter of the PVs and the velocity reflux flow through PVs. Arteries in the perforator bundles demonstrated low RI, which may be attributed to the presence of arteriovenous shunts. Varicose veins were associated with an increased incidence of nonrestrictive type of blood flow through the tricuspid valve. Conclusions: Sonography demonstrated that additional factors rather than hemodynamics may be attributable to the development of venous ulcers. The most informative parameters of cardiac function, in a patient with varicose veins, are the indicators of diastolic function in both ventricles.

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Section: Discussionmentioning

confidence: 59%

“…7,14 The blood flow bypasses the capillaries, which leads to an impaired transcapillary metabolism, microcirculatory dysfunction, and the subsequent development of trophic ulcers. 25…”

Section: Discussionmentioning

confidence: 99%

Varicose Veins: A Local or Systemic Hemodynamic Disorder?

Каlinin

Suchkov

Laut³

et al. 2020

Journal of Diagnostic Medical Sonography

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“…The values of lactate and gas analysis before and after the treatment with semi synthetic diosmin were not significantly changed in the samples of venous blood, even after the static load (Table 5). For patients with C5-6 EpsAspPr the signs of hyperoxemia were found, and a local increase of lactate and pyruvate levels occurred at the static load 8,18 . Thus, for patients with C5-6 EpsAspPr stage of HVI the levels of partial pressure and oxygen saturation were decreased, while the levels of carbon dioxide and bicarbonates were increased, and the values of lactate and pyruvate were not significantly changed.…”

Section: The Resultsmentioning

confidence: 99%

“…HVI was diagnosed on the left leg (26), right leg (36) or bilaterally (18). The youngest patient was 36, and the oldest 84 years old (X+ SD = 52.3+10.5).…”

Section: The Resultsmentioning

confidence: 99%

Medicamentous treatment of chronic venous insufficiency using semisynthetic diosmin: A prospective study

Maksimović

Jadranin

et al. 2008

Acta chir iugo

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“…21–23 Many theories have been proposed but none has provided an entirely satisfactory, complete and coherent explanation of the events observed at histopathological, cellular, molecular and biochemical levels. 7,24–27…”

Section: Aetiologymentioning

confidence: 99%

Epidemiology and aetiology of C4–6 disease

Bradbury

2010

Phlebology

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Although our understanding of chronic venous insufficiency (CVI) has improved, many important questions remain unanswered. Ensuring that patients are appropriately referred for specialist assessment and then receive evidence-based, cost-effective treatment continues to be challenging. The lifetime of risk of chronic venous ulceration (CVU) is around 1% with approximately 10% ulcers being open at any one time. The incidence skin changes disease is about 10 times greater (10%). However, many of the studies upon which these estimates are based are old and/or methodologically flawed. There is reason to believe that the incidence, prevalence and characteristics of CVI/CVU may have changed considerably over the last 10-20 years and that future change is likely. Further cross-sectional and longitudinal epidemiological studies are required to establish the size and nature of the health-care need going forward in developed and increasingly developing countries. CVI culminating CVU is primarily the result of sustained ambulatory venous hypertension, which in turn arises from superficial and/or deep venous reflux with or without deep vein obstruction. However, there are many other elements to this complex condition, for example, microvascular dysfunction; calf muscle pump efficiency; dermal inflammation; disordered fibroblast function and matrix production; failure of epithelialization; congenital and acquired thrombophilia; malnutrition, obesity and diet; and bacterial colonization. None of the currently available treatment modalities is entirely satisfactory and novel therapies based upon a clearer understanding of the disease at the psychological, genetic, mechanical, microvascular and microscopic level are required.

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Local metabolic, pathophysiological and histological changes in venous ulcers

Abstract: Differences in levels of venous blood gases and anaerobic metabolites indicate a potential difference in the causation and development of superficial versus deep venous caused ulcers. This may have clinical significance for the diagnosis and treatment of these conditions.

Cited by 7 publications

References 13 publications

Varicose Veins: A Local or Systemic Hemodynamic Disorder?

Varicose Veins: A Local or Systemic Hemodynamic Disorder?

Medicamentous treatment of chronic venous insufficiency using semisynthetic diosmin: A prospective study

Epidemiology and aetiology of C4–6 disease

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