Local recurrence rate in patients with DCIS

Abstract

Abstract:Objectives: The aim of this observational retrospective study was to evaluate the local recurrence rate of ductal carcinoma in situ of the breast (DCIS) and/or invasive breast cancer in patients with DCIS or microinvasive carcinoma of the breast after breast conserving or radical surgery. Secondary aim of the study was comprehensive assessment of the whole management of DCIS and its comparison with European guidelines. Methods: The study was performed in a group of 41 women with DCIS or microinvasive cancer, who underwent surgical treatment (breast conserving or radical modifi ed mastectomy) at the IInd Department of Gynaecology and Obstetrics, University Hospital Bratislava (UNB), during the period 2001-2009. Documentation and pathological examination data from paraffi n embedded tissue sections were used as data source. We sent out questionnaires regarding data about additional postoperative treatment and course of the disease up to year 2010 with focus on recurrence or tumour de novo incidence. Results: Breast conserving surgery was performed in 28 cases -68 %, modifi ed radical mastectomy in 13 cases. All cases of mastectomy were due to multicentricity and/or extensive tumour >4 cm. Additional surgery due to unsatisfactory marginal status was performed in 8 patients (3.28 %). Additional treatment such as radiotherapy and/or hormonal therapy received 19 patients. Van Nuyss Prognostic Index was reported in 17 patients on the basis of histopathological data. 27 patients completed and returned questionnaire. No DCIS recurrence nor infi ltrating cancer or tumour de novo was reported in this group. Conclusion: We consider surgical management as adequate. Further material analysis is needed (Tab. 5, Fig. 1

Survival outcomes after breast-conserving surgery plus radiotherapy compared with mastectomy in breast ductal carcinoma in situ with microinvasion

“…They followed up on 41 patients with DCIS or DCIS-MI after BCS and mastectomy, and finally, only 27 patients completed the followup. There is no local recurrence occurred 16 . However, the sample size of this study was small, and no survival www.nature.com/scientificreports/ rate was reported.…”

“…However, considering the good prognosis of DCIS-MI and patients' postoperative life quality, it is worth exploring whether BCS + RT is the best choice for DCIS-MI. At present, there are few studies on the surgical methods of DCIS-MI [16][17][18] . The prognosis of BCS + RT or mastectomy for patients with DCIS-MI is still unclear.…”

Clinical characteristics of breast ductal carcinoma in situ with microinvasion: a narrative review

“…Two other large retrospective analyses 26,27 confirmed that breast-conserving surgery plus postoperative radiotherapy was superior to single-breast resection for patients with early breast cancer. At the same time, it was suggested that age < 40 years, multiple foci or centers, vascular tumor thrombus, tumor location in the central area or inner quadrant, and high nuclear grade were high risk factors for the local recurrence of breast cancer.…”