Abstract. In this paper we confront the weighted tardiness minimization in the job shop scheduling problem with sequence-dependent setup times. We start by extending an existing disjunctive graph model used for makespan minimization to represent the weighted tardiness problem. Using this representation, we adapt a local search neighborhood originally defined for makespan minimization. The proposed neighborhood structure is used in a genetic algorithm hybridized with a simple tabu search method. This algorithm is quite competitive with state-of-theart methods in solving problem instances from several datasets of both classical JSP and JSP with setup times.