Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery

Ratnagobal, Shoba; Taylor, Donna; Bourke, Anita G.; Kessell, Meredith; Madeley, Carolyn; Robert, M; Vlaskovsky, Philip; Saunders, Christobel

doi:10.1002/jmrs.687

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Furthermore, its greatest advantage is that it allows for the localization of the sentinel lymph node with the same radiotracer ( 49 , 50 ). Radioactive iodine seed has a small size of 4.5 mm and can be placed five days before surgery ( 58 ). It also does not have depth limitations for detectability ( 11 ).…”

Section: Localization Methods For Non-palpable Breast Lesionsmentioning

confidence: 99%

Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective

Cheung,

Co,

Lui

et al. 2024

Transl Breast Cancer Res

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Background and Objective With an increasing number of non-palpable breast lesions detected due to improved screening, accurate localization of these lesions for surgery is crucial. This literature review explores the evolution of localization methods for non-palpable breast lesions, highlighting the translational journey from concept to clinical practice. Methods A comprehensive search of PubMed, Embase, and Scopus databases until September 2023 was conducted. Key Content and Findings Multiple methods have been developed throughout the past few decades. (I) Wire-guided localization (WGL) introduced in 1966, has become a reliable method for localization. Its simplicity and cost-effectiveness are its key advantages, but challenges include logistical constraints, patient discomfort, and potential wire migration. (II) Intraoperative ultrasound localization (IOUS) has shown promise in ensuring complete lesion removal with higher negative margin rates. However, its utility is limited to lesions visible on ultrasound (US) imaging. (III) Breast biopsy marker localization: the use of markers has improved the precision of localization without the need for wire. However, marker visibility remains a challenge despite improvements in their design. (IV) Radioactive techniques: radio-guided occult lesion localization (ROLL) and radioactive seed localization (RSL) offer flexibility in scheduling and improved patient comfort. However, they require close multidisciplinary collaboration and specific equipment due to radioactive concerns. (V) Other wireless non-radioactive techniques: wireless non-radioactive techniques have been developed in recent three decades to provide flexible and patient-friendly alternatives. It includes magnetic seed localization, radar techniques, and radiofrequency techniques. Their usage has been gaining popularity due to their safety profile and allowance of more flexible scheduling. However, their high cost and need for additional training remain a barrier to a wider adoption. Conclusions The evolution of breast lesion localization methods has progressed to more patient-friendly techniques, each with its unique advantages and limitations. Future research on patient-reported outcomes, cosmetic outcomes, breast biopsy markers and integration of augmented reality with breast lesion localization are needed.

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Section: Localization Methods For Non-palpable Breast Lesionsmentioning

confidence: 99%

Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective

Cheung,

Co,

Lui

et al. 2024

Transl Breast Cancer Res

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Use of 125 iodine seeds for intra-operative localization of nonpalpable breast lesions (ROLLIS): analysis of the implant of 1757 seeds in 1477 patients

Penna,

da Silva Franca,

de Oliveira

et al. 2024

Holist Integ Oncol

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Objective To analyze the feasibility, efficacy and results of the use of 125Iodine seeds for intra-operative localization of nonpalpable breast lesions. Method Retrospective review of 1477 patients referred by various breast specialist surgeons, with radiologically detected but clinically nonpalpable microcalcifications, asymmetric density or nodules, submitted to pre-operatory 125Iodine seed implant, between July 2012 and September 2023. A total of 1757 seeds were implanted in ordinary radiologic departments, supported by ultrasonography or mammography exams, chosen according to the morphologic aspect of the lesion. Radioguided surgical procedure took place on the same day or few days after the implant of the seeds, with the help of a radiation detector called Gamaprobe, which directs the surgeons towards the radioactive seeds and to the lesion to be resected. Results All implants were performed as outpatient procedures, with patients immediately returning to their daily activities. No complications such as pain, bleeding, infection, and hematoma were recorded. Pathologists had no difficulty in preparing the surgical specimens for histopathologic analysis. Surgical safety margins were considered adequate in all pathologic reports, with no need for re-operations. The healing process was not jeopardized by radiation, and the surgeons were pleased with the improvement in intraoperative lesion localizations and the shortening on operatory time. Cosmetic results were well accepted by the patients. Conclusion The 125Iodine seed implant is an effective alternative method for intraoperative localization of radiologically detectable and clinically nonpalpable breast lesions.

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Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery

Cited by 2 publications

References 30 publications

Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective

Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective

Use of 125 iodine seeds for intra-operative localization of nonpalpable breast lesions (ROLLIS): analysis of the implant of 1757 seeds in 1477 patients

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