Localized Benign and Malignant Fibrous Tumors of the Pleura

England, Douglas M.; Hochholzer, Liselotte; McCarthy, Michael J.

doi:10.1097/00000478-198908000-00003

Cited by 1,258 publications

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“…Previous studies have suggested that tumor size 410 cm is predictive of poor prognosis. 2,10 This also holds true in our cohort, although we found a cutoff size of 15 cm to be the most predictive of metastasis, likely owing to the large tumors in our study.…”

Section: Discussionsupporting

confidence: 65%

“…19 However, older series also found higher metastatic rates in hemangiopericytoma and pleural solitary fibrous tumor-from 18 to 50%. 2,3,16,20 This variability may be due in part to differences in follow-up time as well as referral bias. Adequate follow-up time is required to determine metastatic frequency.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, criteria for malignancy have not been consistent between published series, and the historical attempts at the division of hemangiopericytoma and solitary fibrous tumor has prevented investigations into this class of tumors as an unified spectrum or entity. [2][3][4][5][6][7][8] Several histopathological criteria have been reported to be useful for determining malignancy in solitary fibrous tumor. These include increased tumor size, mitotic count, cellularity, presence of hemorrhage/necrosis, nuclear pleomorphism, 2,3,9-11 and presence of sharply demarcated anaplastic/poorly differentiated foci (also regarded by some as 'dedifferentiation').…”

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confidence: 99%

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Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

et al. 2012

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Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme. Few series have reported on clinicopathological predictors with outcome data and formal statistical analysis in a large series of primary tumors as a single unified entity. Institutional pathology records were reviewed to identify primary solitary fibrous tumor cases, and histological sections and clinical records reviewed for canonical prognostic indicators, including patient age, tumor size, mitotic index, tumor cellularity, nuclear pleomorphism, and tumor necrosis. Patients (n ¼ 103) with resected primary solitary fibrous tumor were identified (excluding meningeal tumors). The most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences. Overall 5-and 10-year metastasis-free rates were 74 and 55%, respectively, while 5-and 10-year disease-specific survival rates were 89 and 73%. Patient age, tumor size, and mitotic index predicted both time to metastasis and disease-specific mortality, while necrosis predicted metastasis only. A risk stratification model based on age, size, and mitotic index clearly delineated patients at high risk for poor outcomes. While small tumors with low mitotic rates are highly unlikely to metastasize, large tumors Z15 cm, which occur in patients Z55 years, with mitotic figures Z4/10 high-power fields require close follow-up and have a high risk of both metastasis and death.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

et al. 2012

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“…Various histologic criteria has been put forward which include lack of circumscription, nuclear atypia, hypercellularity, a mitotic count greater than or equal to four per 10 HPF and presence of necrosis. Additional criteria, like clinical aggressiveness, large size ([50 cm) resectability, invasiveness, infiltrative margins have also been proposed [5,8,18,19].…”

Section: Discussionmentioning

confidence: 99%

An Aggressive Solitary Fibrous Tumor with Evidence of Malignancy: A Rare Case Report

Vimi

Punnya

Hallikeri

et al. 2008

Head and Neck Pathol

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Solitary fibrous tumor (SFT) is rare mesenchymal neoplasm that has been originally and most often documented in the pleura. Recently, the ubiquitous nature of the SFT has been recognized with reports of involvement of numerous sites all over the body, i.e, upper respiratory tract, breast, somatic tissue, mediastinum, head, and neck, etc. The diagnosis of SFT still remains an enigma in our field. Furthermore, malignant SFT is extremely rare and only two cases have been reported in the oral cavity till date. Here, we present a rare case report of an aggressive solitary fibrous tumor which presented as a palatal mass and extended throughout the middle cranial fossa and exhibited features of malignancy.

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“…Preoperative differentiation between the benign and malignant types is extremely difficult. CT-scan, angiography, bronchoscopy and needle biopsy may be useful, but for a definitive diagnosis thoracoscopy and tissue examination are necessary [1,8,11,12].…”

Section: Discussionmentioning

confidence: 99%

A patient with fatigue and subfebrile temperature

Herder

Smit

Borgstein³

et al. 2000

Eur Respir J

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Case report A 76-yr-old nonsmoking female was referred for evaluation of complaints of subfebrile temperature and fatigue for 4 weeks. A few days before the visit she developed pain in the back of the left hemithorax and a tickling cough when breathing deeply. Two months earlier she had experienced a period of nonproductive cough, which resolved after medical treatment. There were no other pulmonary symptoms. Past medical history revealed venous thrombosis with pulmonary embolism after a curettage, rheumatoid arthritis and pneumonia.On physical examination she appeared healthy with a pulse of 80 beats . min -1 , blood pressure of 170/90 mmHg and a normal temperature. Apart from dullness over the basal part of the left hemithorax with normal breath sounds, physical examination was normal. Except for an erythrocyte sedimentation rate of 79 mm, laboratory tests were within normal limits.

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Localized Benign and Malignant Fibrous Tumors of the Pleura

Cited by 1,258 publications

References 0 publications

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

An Aggressive Solitary Fibrous Tumor with Evidence of Malignancy: A Rare Case Report

A patient with fatigue and subfebrile temperature

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