Localized dystrophic amyloidosis of heart valves

Cooper, John H.

doi:10.1016/s0046-8177(83)80208-1

Cited by 38 publications

(14 citation statements)

References 11 publications

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“…Ice‐cold water was added to amyloid precipitate, and this was immediately followed by analysis by Congo red staining and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS‐PAGE). Extracts were coated on eight‐well slides containing gelatin, and a Congo red staining method was used as described previously 11 to confirm the presence of amyloid fibrils in the extracts.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, considering the importance of apoptosis during pathological mineralization, 10 it is possible that amyloid substance plays a role in the development of CAVD. In this regard, previous studies have shown the presence of amyloid substance in human heart valves 11–13 . However, so far, amyloid substance has not been isolated from CAVD valves, and its impact on the mineralization of human primary valvular interstitial cells (VICs) has not been explored.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, previous studies have shown the presence of amyloid substance in human heart valves. [11][12][13] However, so far, amyloid substance has not been isolated from CAVD valves, and its impact on the mineralization of human primary valvular interstitial cells (VICs) has not been explored.…”

Section: Introductionmentioning

confidence: 99%

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Amyloid substance within stenotic aortic valves promotes mineralization

Audet¹,

Côté²,

Couture³

et al. 2012

Histopathology

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amyloid substance within stenotic aortic valves promotes mineralization

Audet¹,

Côté²,

Couture³

et al. 2012

Histopathology

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“…2 Isolated amyloid infiltration in the absence of valve scarring is less common and has not been reported in association with clinical sequelae. 3 We describe a unique case of a young fit man presenting with acute myocardial infarction secondary to embolism arising from a bicuspid aortic valve.…”

mentioning

confidence: 99%

Amyloid, thrombosis, and acute myocardial infarction in association with a bicuspid aortic valve.

Groves

Douglas-Jones²,

Hall³

1993

Heart

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The clinical diagnosis was inferior myocardial infarction, which was presumed to have resulted from a right coronary embolus arising from the abnormal aortic right coronary cusp. The patient was anticoagulated with warfarin, remained afebrile, and made an uncomplicated recovery. The electrocardiogram showed normalisation of the inferior T waves without the development of Q waves. Blood cultures were negative.Six weeks later the aortic valve was replaced by a tilting disc prosthesis. Examination of the native aortic valve confirmed that it was originally bicuspid with congenital fusion of the right and non-coronary cusps. The right coronary portion of the fused cusp was totally replaced by a protuberant mass that impinged on the left coronary cusp and spread inferiorly towards the adjacent left ventricular wall. There was no macroscopic evidence of infection. The coronary orifices were normally situated and the cooling pattern of the myocardium during the administration of cold cardioplegia was uniform, implying the absence of obstructive coronary artery disease. Specimens from the excised valve were sterile on culture.Postoperative recovery was uneventful and the patient has since remained fit and well. An exercise stress test performed two months after aortic valve replacement was normal.

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“…With regard to the qualitative aspects, it has been possible by means of immunohistochemical studies to characterize various types of amyloid, each with its own antigen properties , van de Kaa et al 1986. With regard to the quantitative aspects, amyloid deposits are no longer considered rare, inasmuch as they have been demonstrated as micro-deposits, especially in the brain tissue of elderly persons (Schwartz 1970, Stam et al 1986), in the cardiovascular system (Westermark et al 1979, Falk et al 198 1, Cornwell et a1 1982, Cooper 1983, Ladefoged et al 1984 and in joint tissue (Christensen et al 1972, Ladefoged et al 1980, Ladefoged 1985,1986) with a frequency that is close to that of other degenerative diseases such as arteriosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Amyloid deposits in surgically removed articular and periarticular tissue

Ladefoged¹,

Merrild

Jørgensen

1989

Histopathology

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In tissue from 13 of 30 patients subjected to meniscectomy, amyloid degeneration was found to varying extent along the surface of the meniscus. Tissue from 30 synovectomies, 30 bursectomies and 30 ganglia showed amyloid deposits in four, six and eight cases, respectively. Amyloid was found significantly more frequently in older patients, but there was no sex difference and no relation to duration of the symptoms or to other histological changes in the tissue. Micro-deposits of amyloid in joint tissue and tissue neighbouring joints are a frequent finding, especially in elderly persons, but the clinical significance of this finding is not clear.

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Localized dystrophic amyloidosis of heart valves

Cited by 38 publications

References 11 publications

Amyloid substance within stenotic aortic valves promotes mineralization

Amyloid substance within stenotic aortic valves promotes mineralization

Amyloid, thrombosis, and acute myocardial infarction in association with a bicuspid aortic valve.

Amyloid deposits in surgically removed articular and periarticular tissue

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