Localized Form of Multiple Glomus Tumors: Report of the First Case Showing Partial Involution

Abstract

We recently examined a boy with relatively large multiple glomus tumors on the left scapular region. Histologic examination revealed a typical non-capsulated glomangioma in the middle and deep dermis; by electron microscopic examination, the tumor cells were seen to exhibit a characteristic smooth muscle cell structure. Thermographic examination revealed the higher temperature of the tumor. Within a year, the tumor showed a partial involution. We think this is the first report of multiple glomus tumor showing a partial involution.

Four common glomulin mutations cause two thirds of glomuvenous malformations ("familial glomangiomas"): evidence for a founder effect

“…[3][4][5] Glomus cells stain positively for smooth muscle aactin and vimentin, whereas they are negative for desmin, von Willebrand factor, and S-100 neuronal marker. 6 In addition, glomus cells have electronmicroscopic characteristics of smooth muscle 7 and thus are considered to be abnormally differentiated vascular smooth muscle cells. 6 We previously reported that families with autosomal dominant inheritance of GVM link to chromosome 1p21-22, 3 and we identified linkage disequilibrium for seven families in a region of 1.48 Mbp in the VMGLOM locus.…”

“…6 In addition, glomus cells have electronmicroscopic characteristics of smooth muscle 7 and thus are considered to be abnormally differentiated vascular smooth muscle cells. 6 We previously reported that families with autosomal dominant inheritance of GVM link to chromosome 1p21-22, 3 and we identified linkage disequilibrium for seven families in a region of 1.48 Mbp in the VMGLOM locus. 8 By positional cloning using YAC and PAC based physical maps, 9 we identified a novel gene, glomulin (glmn), with unknown function, mutated in GVM.…”

Multiple Glomus Tumors: Recognition and Diagnosis

“…Usually the disease presents stable behavior, with the eventual appearance of new tumors being related to small traumatisms, repeated pregnancy, or appearing spontaneously 16, 28 . Although less common, partial regression of the lesions was noticed in one case 29 …”

Multiple glomus tumours in an octuagenarian

“…Congenital forms, although rare, have been described [11,15]. The histopathological findings are different in solitary and multiple GTs [16].…”