Localized limb cutaneous metastases

Skin lesions as the first manifestation of follicular lymphoma

“…Moreover, this and other described cases show that skin lesions can be the first manifestation of follicular lymphoma. This case also highlights the need for collaboration between clinicians and pathomorphologists, as well as for persistently seeking the correct diagnosis when there is an ne chłoniaki B-komórkowe [10], mięsaka Kaposiego [11,12], papillomatosis cutis lymphostatica [13] oraz przerzuty skórne innych nowotworów [14]. W tabeli 1 przedstawiono różnicowanie chłoniaków skóry na podstawie wyników badania immunhistochemicznego [15][16][17].…”

“…Based on the available images from medical publications, we could not find any other case of such advanced and extensive secondary skin lesions as in our patient, making this case unique. The differential diagnosis of multiple pink-red nodules on the skin of the lower limbs should include primary or secondary B-cell lymphoma [10], Kaposi's sarcoma [11,12], papillomatosis cutis lymphostatica [13] and cutaneous metastases of other tumours [14]. Table 1 shows the differentiation of cutaneous lymphomas based on immunohistochemical Bcl2 (+), MUM1 (+/-), CD3 (-), Bcl6 (+/-), MYC (-), CD5 (-), cyklina D1 (-), TdT (-), CD10 (+) (ryc.…”

Metastatic adenocarcinoma of breast within a benign melanocytic nevus in the context of cutaneous breast metastatic disease

“…The others are carcinoma telangiectaticum, 13,18,19 alopecia neoplastica, 20,21 Paget's disease, 22‐26 breast carcinoma of the inframammary crease, 27 metastatic mammary carcinoma of the eyelid with histiocytoid histology, 28 nodular metastases 29‐31 and mucinous adenocarcinoma metastatic to skin 1,2,10 . Telangiectatic metastatic carcinoma has violaceous papulovesicles that may resemble lymphangioma circumscriptum, as tumor cells fill superficial lymphatic and blood vessels as a result of hematogenous spread.…”

“…Breast cancer of the inframammary crease appears as a cutaneous exophytic nodule suggestive of a primary cutaneous squamous cell carcinoma, basal cell carcinoma or an epidermal inclusion cyst. The nodular type of metastatic cutaneous breast cancer may be evident as multiple firm papules or nodules, sometimes in a zosteriform pattern 29‐31 . For the various types of cutaneous breast metastases, spread of the breast cancer cells may occur through lymphatics, blood vessels or by direct extension 16,32 …”