Localized Meningoencephalitis and Group A Streptococcal Bacteremia

Levy, Eric N.; Griffith, James A.; Carvajal, Hugo F.

doi:10.1177/000992289203100712

Clin Pediatr (Phila)

1992

DOI: 10.1177/000992289203100712

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Localized Meningoencephalitis and Group A Streptococcal Bacteremia

Eric N. Levy¹,

James A. Griffith²,

Hugo F. Carvajal³

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1999

2024

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Cited by 6 publications

References 10 publications

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Group A Streptococcal meningitis in children: a short case series and systematic review

Dou,

Li,

et al. 2024

Eur J Clin Microbiol Infect Dis

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Background Group A streptococcal(GAS) meningitis is a severe disease with a high case fatality rate. In the era of increasing GAS meningitis, our understanding about this disease is limited. Purpose To gain a better understanding about GAS meningitis. Methods Five new cases with GAS meningitis were reported. GAS meningitis related literatures were searched for systematic review in PUBMED and EMBASE. Case reports and case series on paediatric cases were included. Information on demographics, risk factors, symptoms, treatments, outcomes, and emm types of GAS was summarized. Results Totally 263 cases were included. Among 100 individuals, 9.9% (8/81) had prior varicella, 11.1% (9/81) had anatomical factors, and 53.2% (42/79) had extracranial infections. Soft tissue infections were common among infants (10/29, 34.5%), while ear/sinus infections were more prevalent in children ≥ 3 years (21/42, 50.0%). The overall case fatality rate (CFR) was 16.2% (12/74). High risk of death was found in patients with shock or systemic complications, young children(< 3 years) and cases related to hematogenic spread. The predominate cause of death was shock(6/8). Among the 163 patients included in case series studies, ear/sinus infections ranged from 21.4 to 62.5%, while STSS/shock ranged from 12.5 to 35.7%, and the CFR ranged from 5.9 to 42.9%. Conclusions A history of varicella, soft tissue infections, parameningeal infections and CSF leaks are important clinical clues to GAS in children with meningitis. Young children and hematogenic spread related cases need to be closely monitored for shock due to the high risk of death.

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Group A Streptococcal meningitis in children: a short case series and systematic review

Dou,

Li,

et al. 2024

Eur J Clin Microbiol Infect Dis

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Group A Streptococcal Meningitis in the Antibiotic Era

Baraldès¹,

Domingo²,

Mauri³

et al. 1999

European Journal of Clinical Microbiology & Infectious Dise

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A case of group A streptococcal meningitis is reported and the 51 cases reported in the literature since 1966 reviewed. A total of 24 men and 24 women were included in the study; the mean age (+/-SD) was 20.9+/-25.5 years. Fifty-eight percent of the patients had comorbid conditions, 80% had a distant focus of infection, and 65.8% had blood cultures positive for group A streptococci. Seventy-five per cent of the patients were treated with penicillin. The overall case-fatality rate was 12% (6 patients). Sequelae were more prevalent among children (44%) than among adults (7.7%) (OR=9.43; 95% CI, 1.02-438.95; P=0.03). Group A streptococcus is a rare cause of pyogenic meningitis, affecting mainly children or adults with comorbidity. Although the case-fatality rate is relatively low, neurological sequelae are frequent among survivors, especially children.

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Zapalenie opon mózgowo-rdzeniowych o etiologii Streptococcus pyogenes – opis przypadku

Rumińska¹,

Rogozińska²,

Witkowska–Sędek³

et al. 2014

Pediatria Polska

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Localized Meningoencephalitis and Group A Streptococcal Bacteremia

Cited by 6 publications

References 10 publications

Group A Streptococcal meningitis in children: a short case series and systematic review

Group A Streptococcal meningitis in children: a short case series and systematic review

Group A Streptococcal Meningitis in the Antibiotic Era

Zapalenie opon mózgowo-rdzeniowych o etiologii Streptococcus pyogenes – opis przypadku

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