“…[4] Compared with the chipbased sensors, fiber optic (FO) sensing probe has the advantages of miniaturized, real-time monitoring, and portability. [8,9] So far, a variety of side-coated FO probes have been designed, and the introduction of some functional materials including gold nanoparticles, [10] nanorod monolayer, [11,12] nanodonuts, [13] graphene, [14,15] polyelectrolyte, [16] Teflon, [17] and metal oxides [18][19][20] not only improve the sensitivity of the SPR sensors but also broaden their functional detection applications such as protein-specific binding and DNA detection. Modified D-shaped and U-bent FO sensors also achieve protein-specific binding and other biosensing detection with excellent detection limits.…”