Localized surface plasmon resonance-based biosensor on gold nanoparticles for Taenia solium detection

Arcas, Ariadny da Silva; Jaramillo, Lizeth Yuliana Acevedo; Costa, Natália Silva; Allil, Regina C.; Werneck, Marcelo Martins

doi:10.1364/ao.432990

Cited by 10 publications

(7 citation statements)

References 45 publications

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“…The surface plasmon resonance effect causes an absorbance band in the electromagnetic spectrum, usually in the visible light range. Particle size and shape, coating, particle spacing, and other variables can all have an impact on the peak [ 78 , 79 , 80 , 81 ]. The fact that we observed the peak at the region 410–450 nm corresponds with the literature data for spherical nanoparticles [ 45 , 82 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

et al. 2023

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Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles. Results: The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary.

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Section: Resultsmentioning

confidence: 99%

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

et al. 2023

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“…The position of the SPR in the visible part of the spectrum also serves as a reference for the shape of the nanoparticles [ 64 , 65 , 66 , 67 , 68 ]. The wavelength of the SPR peak is in the region 410–450 nm, which is indicative of the spherical shape of the obtained nanoparticles [ 41 , 69 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant

Nikolova,

Milusheva,

Gledacheva

et al. 2023

Biomedicines

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Anticoagulants prevent the blood from developing the coagulation process, which is the primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known anticoagulant that is rarely employed because it totally prevents coagulation, which can be a life-threatening complication. The goal of the current study is to synthesize drug-loaded Ag NPs to slow down the coagulation process. Methods: A rapid synthesis and stabilization of silver nanoparticles as drug-delivery systems for phenindione (PID) were applied for the first time. Results: Several methods are used to determine the size of the resulting Ag NPs. Additionally, the drug-release capabilities of Ag NPs were established. Density functional theory (DFT) calculations were performed for the first time to indicate the nature of the interaction between PID and nanostructures. DFT findings supported that galactose-loaded nanostructure could be a proper delivery system for phenindione. The drug-loaded Ag NPs were characterized in vitro for their antimicrobial, cytotoxic, and anticoagulant activities, and ex vivo for spasmolytic activity. The obtained data confirmed the drug-release experiments. Drug-loaded Ag NPs showed that prothrombin time (PT, sec) and activated partial thromboplastin time (APTT, sec) are approximately 1.5 times longer than the normal values, while PID itself stopped coagulation at all. This can make the PID-loaded Ag NPs better therapeutic anticoagulants. PID was compared to PID-loaded Ag NPs in antimicrobial, spasmolytic activity, and cytotoxicity. All the experiments confirmed the drug-release results.

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“…The localized surface plasmon resonance (LSPR) effect causes an absorbance band in the electromagnetic spectrum, usually in the visible light range. The absorption peak can be altered by variations in different factors such as the particle size and shape, coating, the distance between particles, pH, temperature, the number and types of ligands linked to the gold core, as well as the surrounding physicochemical environment [44][45][46]. A plasmon band of AuNPs is thus sensitive to the chemical environment in which they are found.…”

Section: Influence Of Loading Time On Drug Releasementioning

confidence: 99%

Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy

Raiche-Marcoux¹,

Loiseau²,

Maranda³

et al. 2022

IJMS

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Eye drops represent 90% of all currently used ophthalmic treatments. Only 0.02% of therapeutic molecules contained in eye drops reach the eye anterior chamber despite their high concentration. The tear film efficiently protects the cornea, reducing access to the target. Thereby, the increase in the drug bioavailability and efficiency must come from the mucoadhesion optimization of the drug delivery system. The gold nanoparticles, used as a drug delivery system in this study, already showcased ultrastable and mucoadhesive properties. The goal was to study the gold nanoparticles’ ability to release two specific ophthalmic drugs, flurbiprofen and ketorolac. The parameters of interest were those involving the loading conditions, the gold nanoparticles properties, and the release experimental conditions. The drug release was measured using an in vitro model based on dialysis bags coupled with UV–visible spectroscopy. Gold nanoparticles showed an ability to release different molecules, whether hydrophobic or hydrophilic, in passive or active drug release environments. Based on these preliminary results, gold nanoparticles could represent a promising drug delivery system for ketorolac and flurbiprofen when topically applied through eye drops.

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Localized surface plasmon resonance-based biosensor on gold nanoparticles for Taenia solium detection

Cited by 10 publications

References 45 publications

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant

Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy

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