Lockdown During COVID-19 and the Increase of Frailty in People With Neurological Conditions

Pelicioni, Paulo Henrique Silva; Schulz-Moore, Jennifer S.; Hale, Leigh; Canning, Colleen G.; Lord, Stephen R.

doi:10.3389/fneur.2020.604299

Cited by 18 publications

(26 citation statements)

References 56 publications

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“…Although the lockdown on vulnerable populations was an essential step, some critical aspects of social isolation and primary service interruption have recently been highlighted [4,5]. Indeed, these aspects negatively reflect physical, cognitive, and mental health outcomes for people with chronic neurological conditions, who need extensive and continuous care, regular physical activity, and daily routine and balance [6].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic

et al. 2021

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During the COVID-19 pandemic and the related lockdowns, outpatient follow-up visits for patients with chronic neurological diseases have been suspended. Managing people affected by amyotrophic lateral sclerosis (ALS) has become highly complicated, leaving patients without the standard multidisciplinary follow-up. This study aimed to analyze the impact of the COVID-19 lockdown on ALS disease progression. We compared the clinical data and progression in the first year following diagnosis for patients who received ALS diagnosis during 2020 (G20, N = 34), comparing it with a group of diagnosed in 2018 (G18, N = 31). Both groups received a comparable multidisciplinary model of care in our Tertiary Expert ALS Centre, Novara, Italy. The monthly rate of ALSFRS-R decline during the lockdown was significantly increased in G20 compared to G18 (1.52 ± 2.69 vs. 0.76 ± 0.56; p-value: 0.005). In G20, 47% required non-invasive ventilation (vs. 32% of G18). Similarly, in G20, 35% of patients died vs. 19% of patients in G18 (p-value: 0.01). All results were corrected for gender, age, site of onset, and diagnostic delay. Several factors can be implicated in making ALS more severe, with a faster progression, such as reduced medical evaluations and the possibility of therapeutic changes, social isolation, and rehabilitation therapy suspension.

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Section: Introductionmentioning

confidence: 99%

Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic

et al. 2021

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“…Pelicioni et al [ 35 ] have reported that individuals with CND such as stroke, PD, and MS are vulnerable to complications of illness because they did not receive the necessary care, especially during forced lockdown, in a review which is evaluating data from several countries. In addition to the results of Pelicioni et al [ 35 ], our data indicated that the QoL was lower especially in the group with disrupted treatment.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that living alone, a lower level of education, not having children, or having >2 children, living in urban areas, female gender, age, past psychiatric history, substance abuse, and poor self-care are factors associated with depression, anxiety, and stress in various studies [ 26 , 27 , 29 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. In our study, because the percentage of people living alone is low (6%), no interpretation could be made in terms of PTSD risk.…”

Section: Discussionmentioning

confidence: 99%

The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study

et al. 2021

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Background: Coronavirus disease 2019 (COVID-19) pandemic and lockdown period may induce an impairment in quality of life (QoL), disruption in treatment (DIT), and posttraumatic stress disorder (PTSD) in chronic neurological diseases (CNDs). To reach this information, a multicenter, cross-sectional study (COVQoL-CND) was planned. Parkinson’s disease (PD), headache (HA), multiple sclerosis (MS), epilepsy (EP), polyneuropathy (PNP), and cerebrovascular disease (CVD) were selected as the CND. Methods: The COVQoL-CND study includes demographic data, the World Health Organization Quality of Life short form (WHOQOL-BREF), and Impact of Event Scale-Revised (IES-R) forms. Results: The mean age of a total of 577 patients was 49 ± 17 (19–87 years), and the ratio of female/male was 352/225. The mean age of patients with PD, HA, MS, EP, PNP, and CVD were 65 ± 11, 39 ± 12, 38 ± 10, 47 ± 17, 61 ± 12, and 60 ± 15 years, respectively. The IES-R scores were found to be higher in the younger group, those with comorbid disease, contacted with COVID-19 patients, or diagnosed with COVID-19. In the group with a high IES-R score, the rate of DIT was found to be high. IES-R scores were negatively correlated with QoL. IES-R total scores were found highest in the CVD group and lowest in the PD group. The ratio of DIT was found highest in the PNP group and the lowest in the EP group. Contact with COVID-19 patients was high in the EP and HA group. Conclusions: The results of the COVQoL-CND study showed that lockdown causes posttraumatic stress and deterioration in the QoL in CND.

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“…Specifically, studies have shown increased frailty, worsening of symptoms, or accelerated progression of disease in patients with Parkinson's, multiple sclerosis, or adults with cognitive impairment and dementia. 28 Further, studies have shown worsening of neurological condition in children with existing neurological disorder, as well as worsening of papilledema in patients with new or existing idiopathic intracranial hypertension. 29,30 For other neurological diseases, such as pediatric epilepsy, remote consultations and telemedicine emerged as feasible avenues to continue following patients in the elective setting while avoiding unnecessary visits and exposure to SARS-CoV-2.…”

Section: Neurosurgical Practicementioning

confidence: 99%

The impact of coronavirus 2019 (COVID-19) on neurosurgical practice and training: a review article

Alimohammadi

Eden

Anand

et al. 2021

British Journal of Neurosurgery

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The 2019 coronavirus pandemic (COVID-19) has affected all of society at different levels. Similarly, COVID-19 has significantly impacted every medical field, including neurosurgery. By exposing scarcities in the healthcare industry and requiring the reallocation of available resources towards the priority setting and away from elective surgeries and outpatient visits, the pandemic posed new, unprecedented challenges to the medical community. Despite the redistribution of resources towards COVID-19 patients and away from elective surgeries, urgent and emergent surgeries for life-threatening conditions needed to be continued. The neurosurgical community, like other specialties not directly involved in the care of COVID-19 patients, initially struggled to balance the needs of COVID-19 patients with those of neurosurgical patients, residents, and researchers. Several articles describing the effect of COVID-19 on neurosurgical practice and training have been published throughout the COVID-19 pandemic. This article aims to provide a focused review of the impact COVID-19 has had on neurosurgical practice and training as well as describe neurological manifestations of the disease.

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Lockdown During COVID-19 and the Increase of Frailty in People With Neurological Conditions

Cited by 18 publications

References 56 publications

Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic

Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic

The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study

The impact of coronavirus 2019 (COVID-19) on neurosurgical practice and training: a review article

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