Locomotor activity and learning and memory abilities in Alzheimer’s disease induced by Aluminum in an acid environment in Zebrafish

He, Xiong; Zhong, Zhaoming; Che, Yi

doi:10.3724/sp.j.1141.2012.02231

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Learning and memory deficits have also been observed in these fish 106 . Zebrafish treated with Aluminium in an acid environment displayed behaviour with AD-like condition wherein their locomotor activity and learning ability got abrogated 107 . Furthermore, it has been reported that intraventricular injection of Aβ 1–42 in the embryonic brain leads to memory loss and cognitive deficits along with increased Tau phosphorylation 104 , 108 .…”

Section: Zebrafish As An Ad Modelmentioning

confidence: 99%

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

2018

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Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational research on human neurological disorders. In this review, we appraise the high degree of neurological and behavioural resemblance of zebrafish with humans. It is highly validated as a powerful vertebrate model for investigating human neurodegenerative diseases. The neuroanatomic and neurochemical pathways of zebrafish brain exhibit a profound resemblance with the human brain. Physiological, emotional and social behavioural pattern similarities between them have also been well established. Interestingly, zebrafish models have been used successfully to simulate the pathology of Alzheimer’s disease (AD) as well as Tauopathy. Their relatively simple nervous system and the optical transparency of the embryos permit real-time neurological imaging. Here, we further elaborate on the use of recent real-time imaging techniques to obtain vital insights into the neurodegeneration that occurs in AD. Zebrafish is adeptly suitable for Ca2+ imaging, which provides a better understanding of neuronal activity and axonal dystrophy in a non-invasive manner. Three-dimensional imaging in zebrafish is a rapidly evolving technique, which allows the visualisation of the whole organism for an elaborate in vivo functional and neurophysiological analysis in disease condition. Suitability to high-throughput screening and similarity with humans makes zebrafish an excellent model for screening neurospecific compounds. Thus, the zebrafish model can be pivotal in bridging the gap from the bench to the bedside. This fish is becoming an increasingly successful model to understand AD with further scope for investigation in neurodevelopment and neurodegeneration, which promises exciting research opportunities in the future.

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Section: Zebrafish As An Ad Modelmentioning

confidence: 99%

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

2018

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“…Zebrafish have been used extensively in the creation of animal AD models to better understand the pathology of the disease. Alzheimer's in zebrafish has been induced via both neuropharmacological [213][214][215][216] and genetic means [91,[217][218][219]. Such models have been invaluable in the conduct of research geared towards finding targets for treatment.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease

Chaoul,

Dib,

Bedran

et al. 2023

IJMS

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Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world’s population. The burden of the resulting deaths and disability is set to rise during the next few decades as a consequence of an aging population. To address this, zebrafish have become increasingly prominent as a model for studying human neurological diseases and exploring potential therapies. Zebrafish offer numerous benefits, such as genetic homology and brain similarities, complementing traditional mammalian models and serving as a valuable tool for genetic screening and drug discovery. In this comprehensive review, we highlight various drug delivery techniques and systems employed for therapeutic interventions of neurological diseases in zebrafish, and evaluate their suitability. We also discuss the challenges encountered during this process and present potential advancements in innovative techniques.

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“…Além disso, foi relatado que a injeção intraventricular de Aβ 1-42 no cérebro embrionário leva à perda de memória e déficits cognitivos, juntamente com o aumento da fosforilação de Tau. O zebrafish está, portanto, emergindo como um modelo poderoso para pesquisa no campo da neurofarmacologia (BEST et al, 2008;NERY et al, 2014;CHEN et al, 2011;NADA;WILLIAMS;SHAH, 2016;HE;ZHONG;CHE, 2012;PAQUET;SCH-MID;HAASS, 2010).…”

Section: Zebrafish Como Modelo Para Daunclassified

Métodos Experimentais Para Estudos Não Clínicos Da Doença De Alzheimer

2022

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Os autores se responsabilizam publicamente por esta obra, garantindo que o mesmo é de autoria própria, assumindo integral responsabilidade diante de terceiros, quer de natureza moral ou patrimonial, em razão de seu conteúdo, declarando que o trabalho é original, livre de plágio e que não infringe quaisquer direitos de propriedade intelectual de terceiros. Os autores declaram não haver qualquer interesse comercial ou irregularidade que comprometa a integridade desta obra. SUMÁRIOAPRESENTAÇÃO CAPÍTULO 1 PRINCIPAIS MODELOS ANIMAIS DE INDUÇÃO DA DOENÇA DE ALZHEIMER Modelo animal triplo transgênico Modelo animal duplo transgênico Modelo por infusão intracerebroventricular (i.c.v.) Peptídeo β-amiloide Lipopolissacarídeo (LPS) Estreptozotocina Indução por Alumínio Indução da DA em neurônios do hipocampo (Cultura celular) CAPÍTULO 2 PROTOCOLOS PARA ANÁLISE DOS MODELOS EXPERIMENTAIS Protocolo de avaliação em campo aberto Labirinto Aquático de Morris (Morris Water Maze) Teste de suspensão pela cauda Teste labirinto em cruz elevado Teste de realocação de objetos Avaliação do estresse oxidativo Atividade da enzima acetilcolinesterase (AchE) Captação de glutamato Fator de necrose tumora (TNF-a) Micróglia ativada Interleucinas 1a, 2, 6, 18 Óxido nítrico Prostaglandina E2 Estrutura química da prostaglandina E 2 Proteína quimiotática de Monócitos (MCP-1) Fator estimulador de colônia (G-CSF) CAPÍTULO 3 ZEBRAFISH COMO MODELO NEUROFARMACOLÓGICO DA DOENÇA DE ALZHEIMER Zebrafish como modelo para DA Zebrafish como modelo neurogenético Estudos de drogas neuroespecíficas usando o modelo de zebrafish REFERÊNCIAS SOBRE OS AUTORES

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Locomotor activity and learning and memory abilities in Alzheimer’s disease induced by Aluminum in an acid environment in Zebrafish

Cited by 8 publications

References 22 publications

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease

Métodos Experimentais Para Estudos Não Clínicos Da Doença De Alzheimer

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