Locus Ceruleus and Immunity. I. Suppression of Plaque-Forming Cell Response and Antibody Production in Rats with Lesioned Locus Ceruleus

Nikolić, Vera; Jovanova-Nešić, Katica; Janković, Branislav D.

doi:10.3109/00207459308994283

Cited by 16 publications

(9 citation statements)

References 10 publications

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“…Accordingly, administration of the bacterial endotoxin LPS led to an activation of the noradrenergic neurons of the nucleus coeruleus and the maximal increased turnover of biogenic amines including norepinephrine was observed at the peak of the immune response [156][157][158]. In addition, stereotaxic lesions of the nucleus coeruleus compromised immune functions including antibody production, immune cell distribution and hypersensitivity skin reaction [159][160][161][162]. A comparable effect was observed after activation of the cellular immune system by induction of the delayed type of hypersensitivity reaction [163].…”

Section: B) Autoimmune Diseasesmentioning

confidence: 99%

Catecholamines: Physiological Immunomodulators During Health and Illness

Oberbeck

2006

CMC

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The existence of an immune-endocrine interaction has been reported and the modulatory effects of the natural occurring catecholamines epinephrine, norepinephrine and dopamine as well as of pharmaceutically generated catecholamines like dopexamine on a wide variety of immune functions were demonstrated. Furthermore, it was noticed that these effects are mediated by specific adrenergic and dopaminergic receptors expressed on the surface of immunological target cells. At first, the adrenergic immunomodulation was predominantly investigated in healthy volunteers and profound immunomodulatory effects were reported for endogenously released and exogenously administered catecholamines. To further elucidate the physiological significance of these interactions, investigators tried to reveal the importance of the catecholaminergic modulation of the immune system under pathological conditions like hemorrhagic shock and systemic inflammation, since catecholamines and adrenergic antagonists are frequently used drugs in the treatment of the critically ill. Furthermore, the interaction between catecholamines and the immune system is supposed to be an important factor in the development of autoimmune diseases and may influence their progress. In addition to the effects of peripheral circulating catecholamines, it was demonstrated that catecholamines that are released within the central nervous system may profoundly influence the activity of the peripheral immune system. Starting with a short historical overview over the immunomodulatory effects of blood catecholamines under good health conditions during critical illness and during autoimmune disease will be reviewed and the immunomodulatory effects of centrally released catecholamines will be discussed.

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Section: B) Autoimmune Diseasesmentioning

confidence: 99%

Catecholamines: Physiological Immunomodulators During Health and Illness

Oberbeck

2006

CMC

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“…In addition the occurrence and intensity of lesions in the central nervous system is markedly diminished, and the production of antibody against rat brain myelin basic protein is reduced. These changes may mainly be related to changes in the periphery, possibly mediated by hypothalamically released steroids, since there is also a reduction of the size of the thymus and a depletion of CD4 + lymphocytes in peripheral blood [378]. EAE may accordingly only reflect the immunological aspects of MS, whereas a primary impairment of astrocytic β-adrenoceptor function is lacking in this model.…”

Section: Multiple Sclerosis Canine Distemper and Eaementioning

confidence: 93%

Astrocytic Adrenoceptors: A Major Drug Target in Neurological and Psychiatric Disorders?

Hertz¹,

Chen²,

Gibbs³

et al. 2004

CDTCNSND

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Considerable attention has recently been paid to astrocyte functions, which are briefly summarized. A large amount of data is available about adrenoceptor expression and function in astrocytes, some of it dating back to the 1970's and some of it very recent. This material is reviewed in the present paper. The brain is innervated by noradrenergic fibers extending from locus coeruleus in the brain stem, which in turn is connected to a network of adrenergic and noradrenergic nuclei in the medulla and pons, contributing to the control of (nor)adrenergic, serotonergic, dopaminergic and cholinergic function, both in the central nervous system (CNS) and in the periphery. In the CNS astrocytes constitute a major target for noradrenergic innervation, which regulates morphological plasticity, energy metabolism, membrane transport, gap junction permeability and immunological responses in these cells. Noradrenergic effects on astrocytes are essential during consolidation of episodal, long-term memory, which is reinforced by β-adrenergic activation. Glycogenolysis and synthesis of glutamate and glutamine from glucose, both of which are metabolic processes restricted to astrocytes, occurs at several time-specific stages during the consolidation. Astrocytic abnormalities are almost certainly important in the pathogenesis of multiple sclerosis and in all probability contribute essentially to inflammation and malfunction in Alzheimer's disease and to mood disturbances in affective disorders. Noradrenergic function in astrocytes is severely disturbed by chronic exposure to cocaine, which also changes astrocyte morphology. Development of drugs modifying noradrenergic receptor activity and/or down-stream signaling is advocated for treatment of several neurological/psychiatric disorders and for neuroprotection. Astrocytic preparations are suggested for study of mechanism(s) of action of antidepressant drugs and pathophysiology of mood disorders.

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“…Tabela 13 -Efeitos da administração de clonazepam (3,0mg/kg) ou solução controle deste sobre a porcentagem de apoptose ou de necrose de células da ascite de camundongos induzida pela inoculação com tumor de Ehrlich (5,0 x 10 6 células/animal BINDING ........................................................................... 96 5.12 NIKOLIC et al, 1993).…”

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Efeitos do diazepam sobre o crescimento do tumor ascítico de Ehrlich: envolvimento do Receptor Periférico para Benzodiazepínico (PBR) ou Proteína Translocadora (TSPO)

Sakai¹

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Dedico esta tese, À minha mãe, Pelo exemplo de determinação e coragem, pelo apoio irrestrito, pela compreensão em todos os momentos, pela pessoa que sou hoje, por todo seu amor.Ao meu pai Toshiuke (in memorian) e ao Jum, Pelas boas recordações e aprendizados, pelas conversas e pelo carinho.Aos meus irmãos Flávio e Paulo Roberto e a Rita, Por estarem sempre presentes, pelo apoio constante, pela amizade, por serem parte da minha família e da minha vida.Ao Claudio, Pela compreensão, pela paciência, pelo respeito e pelo carinho. AGRADECIMENTO ESPECIAL Ao Professor Doutor João Palermo NetoNão tenho palavras suficientes para agradecer pela oportunidade em ser sua orientada, pela confiança que depositou em mim desde sempre, pelo aprendizado constante, pelo exemplo de profissionalismo, de liderança e de competência, pelo apoio e incentivo em todos os momentos. Muito Obrigada. AGRADECIMENTOSÀ Faculdade de Medicina Veterinária e Zootecnia (FMVZ) da Universidade de São Paulo (USP). Ao Departamento de Patologia e Toxicologia (VPT) da FMVZ-USP, local onde este trabalho foi realizado. Ao Programa de Patologia Experimental e Comparada, programa pelo qual este trabalho foi desenvolvido. Ao Prof. Dr. Vassilios Papadopoulos pela doação do anticorpo anti-TSPO, pelas sugestões e por ter me recebido em seu laboratório na Universidade McGill. Ao Prof. Dr. Luciano Freitas Felício (VPT-FMVZ-USP) pela amizade, pelo carinho e pelas agradáveis conversas. Ao Prof. Dr. Paulo César Maiorka (VPT-FMVZ-USP) pela amizade, pelo incentivo e pelos conselhos sempre presentes. À Profa. Dra. Dr. Silvana Lima Górniak (VPT-FMVZ-USP) pelo profissionalismo, pelo apoio e pela atenção imediatamente dispensada sempre que precisei. À Profa. Dra. Maria Lúcia Zaidan Dagli (VPT-FMVZ-USP) pelo apoio científico, pelo entusiasmo e pelo carinho demonstrados nos últimos anos. Ao Prof. Dr. Luiz Carlos de Sá Rocha (VPT-FMVZ-USP) pelo apoio e pelos valiosos questionamentos. Ao Prof. Dr. Frederico Azevedo da Costa Pinto (VPT-FMVZ-USP) pela amizade, pelos ensinamentos, pelos momentos científicos e pela atenção sempre dispensada de maneira inquestionável. À pesquisadora Cristina de Oliveira Massoco pela presença constante de modo ímpar, pelos seus conselhos de amiga e de cientista. Aos funcionários do Biotério (VPT-FMVZ-USP): Cláudia, Idalina, Rosiris, Nelson, Herculano e Mauro pela dedicação e atenção diária aos alunos e aos animais utilizados nesses experimentos. Aos funcionários do Laboratório de Farmacologia e Toxicologia (VPT-FMVZ-USP): Priscila, Magali e Ricardo pela ajuda e atenção presente nos experimentos. Às funcionárias da Secretaria (VPT-FMVZ-USP): Cristina, Sílvia e Adriana por toda atenção e carinho. Aos funcionários do Departamento (VPT-FMVZ-USP): Buga, Edson, Lívia, Lúcia, Luciana, Marguite, Raimundo e Shirley pelo ótimo convívio diário. Às funcionárias da Secretaria de Pós-Graduação (FMVZ-USP): Cláudia, Dayse e Joana, pela eficiência e pela ajuda. Aos funcionários da Biblioteca (FMVZ-USP), em especial Elza, Fátima, Helena e Solange, pelo excelente atendimen...

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Locus Ceruleus and Immunity. I. Suppression of Plaque-Forming Cell Response and Antibody Production in Rats with Lesioned Locus Ceruleus

Cited by 16 publications

References 10 publications

Catecholamines: Physiological Immunomodulators During Health and Illness

Catecholamines: Physiological Immunomodulators During Health and Illness

Astrocytic Adrenoceptors: A Major Drug Target in Neurological and Psychiatric Disorders?

Efeitos do diazepam sobre o crescimento do tumor ascítico de Ehrlich: envolvimento do Receptor Periférico para Benzodiazepínico (PBR) ou Proteína Translocadora (TSPO)

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