In order to study the adaptability of regional logistics transportation and regional economy and promote the coordinated operation of logistics transportation and regional economic development, the paper selects 16 indicators related to logistics transportation and economic development, makes principal component analysis to evaluate and analyze the comprehensive development of the indicators, and constructs the fitness evaluation model, the data of Hebei Province from 2007 to 2016 are calculated. According to the fitness function, the results show that the comprehensive development level of regional economy is slightly higher than that of logistics transportation. The fitness value is above 0.4, which does not reach a strong adaptive state, indicating that the logistics transportation and economic development are stable, but can still be improved. The speed of economic development has been rising steadily, but the development speed of logistics transportation has slowed down in the past two years. Therefore, in the future economic development, the construction of logistics transportation needs to be strengthened to guide the rapid economic development.