Long acting aripiprazole influences cognitive functions in recent onset schizophrenia

Peitl, Vjekoslav; Štefanović, Mario; Orlović, Ivona; Culej, Jelena; Rendulić, Ana; Matešić, Krunoslav; Karlović, Dalibor

doi:10.1007/s00213-021-05788-w

Cited by 11 publications

(7 citation statements)

References 48 publications

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“…MTHFR 677T allele carriers have lower levels of total cholesterol and low-density lipoprotein cholesterol than those with the 677CC genotype [ 89 ]. There was a positive association between the COMT—MTHFR interaction and attention in inpatients suffering from recent onset SCZ [ 90 ]. MTHFR A1298C, but not C677T, was associated with the metabolic syndrome, its CC genotype having a 2.4 times higher risk compared to AA genotype [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

et al. 2022

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Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate the relationship between MTHFR gene polymorphisms (677C>T and 1298A>C) and the occurrence of ADHD, BD and SCZ. We retrieved case-control studies that met the inclusion criteria from the PubMed database. Associations between MTHFR polymorphisms (677C>T and 1298A>C) and ADHD, BD and SCZ were measured by means of odds ratios (ORs) using a random effects model and 95% confidence intervals (CIs). Additionally, sensitivity analysis and publication bias were performed. After inclusion criteria were met, a total of five studies with ADHD including 434 cases and 670 controls, 18 studies with BD including 4167 cases and 5901 controls and 44 studies with SCZ including 16,098 cases and 19913 controls were finally included in our meta-analysis. Overall, our meta-analytical results provided evidence that the MTHFR 677C>T was associated with occurrence of BD and SCZ, while the 1298A>C polymorphism was related to ADHD and BD, and additionally the sensitivity analysis indicated these results were stable and reliable. This may provide useful information for relevant studies on the etiology of psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

et al. 2022

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“…Aripiprazole treatment also significantly increases the richness and diversity of the gut microbiota, especially the relative abundance of organisms of the minor genera Clostridium , Peptoclostridium , Intestinibacter , and Christenellaceae , also accompanied by a rise in acetate, butyrate and isovalerate levels ( Cussotto et al, 2019 ). Increased numbers of butyrate-producing bacteria may underlie the cognitive improvement of aripiprazole ( Ning et al, 2021 ; Peitl et al, 2021 ). Studies targeting the in vivo interactions of various BD medications with both the gut microbiota and cognitive function will provide new insights into the mechanisms and side effects of these drugs.…”

Section: Interactions Between the Gut Microbiota And Psychiatric Medi...mentioning

confidence: 99%

Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence

et al. 2022

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Recent studies have reported that the gut microbiota influences mood and cognitive function through the gut-brain axis, which is involved in the pathophysiology of neurocognitive and mental disorders, including Parkinson’s disease, Alzheimer’s disease, and schizophrenia. These disorders have similar pathophysiology to that of cognitive dysfunction in bipolar disorder (BD), including neuroinflammation and dysregulation of various neurotransmitters (i.e., serotonin and dopamine). There is also emerging evidence of alterations in the gut microbial composition of patients with BD, suggesting that gut microbial dysbiosis contributes to disease progression and cognitive impairment in BD. Therefore, microbiota-centered treatment might be an effective adjuvant therapy for BD-related cognitive impairment. Given that studies focusing on connections between the gut microbiota and BD-related cognitive impairment are lagging behind those on other neurocognitive disorders, this review sought to explore the potential mechanisms of how gut microbial dysbiosis affects cognitive function in BD and identify potential microbiota-centered treatment.

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“…The study concluded that COMT has the potential to be a biomarker of cognition in schizophrenic patients [31]. A longitudinal study done in 2020 looked at the association between two genotypes of COMT -rs4680 and rs4818 and response to treatment with antipsychotic drugs in 521 Caucasian schizophrenia patients.…”

Section: Pharmacogenetic Studies On the Effect Of Comt Genotype Polymorphism In Neurological And Psychiatric Disordersmentioning

confidence: 99%

“…COMT Met/Met genotype and COMT interaction with methylenetetrahydrofolate reductase (MTHFR) gene were found to have a positive association with attention and executive functioning. The study concluded that COMT has the potential to be a biomarker of cognition in schizophrenic patients [ 31 ]. A longitudinal study done in 2020 looked at the association between two genotypes of COMT - rs4680 and rs4818 and response to treatment with antipsychotic drugs in 521 Caucasian schizophrenia patients.…”

Section: Reviewmentioning

confidence: 99%

Effect of Catechol-O-Methyltransferase Genotype Polymorphism on Neurological and Psychiatric Disorders: Progressing Towards Personalized Medicine

Srivastava¹,

Ochuba²,

Sandhu³

et al. 2021

Cureus

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Different polymorphisms of the catechol-O-methyltransferase (COMT) gene affect the COMT enzyme activity. The COMT enzyme plays a major role in the pathophysiology of various neurological and psychiatric disorders. This review article aims to discuss what recent research has discovered about the association of COMT genotype polymorphism with neurological and psychiatric disorders and the scope for the knowledge to be applied for advancement in therapeutics. We searched PubMed and Google Scholar databases and found 1656 articles. We included observational studies, clinical trials, and meta-analyses in the English language published between 2019 and 2021. We screened the articles based on the title and the abstract and found 26 relevant articles. Diseases or conditions studied primarily were schizophrenia, Parkinson's disease, Alzheimer's disease, substance use, and depression. This article highlights how genetics influences the susceptibility of an individual to neurological and psychiatric diseases and the variations in the specific symptoms of those diseases. The review showed that the variability in individual response to therapeutic interventions stems from the gene level. This knowledge can contribute towards the dawn of a new era of personalized medicine.

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Long acting aripiprazole influences cognitive functions in recent onset schizophrenia

Cited by 11 publications

References 48 publications

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence

Effect of Catechol-O-Methyltransferase Genotype Polymorphism on Neurological and Psychiatric Disorders: Progressing Towards Personalized Medicine

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